Disclosed are 
oral hygiene regimens comprising a plurality of steps involving the use of two or more oral care products containing actives effective to provide one or more benefits including cleaning, 
antimicrobial, antiplaque, anticaries, anti-calculus, anti-demineralizing, anti-
erosion, antisensitivity / desensitizing, whitening, surface conditioning, 
polishing, and pH-balancing, wherein the plurality of steps are conducted and sequenced for maximizing delivery of oral care actives to target surfaces of a subject's 
oral cavity thereby achieving optimum 
oral health and 
hygiene benefits. In one aspect, a 
regimen comprises at least once daily of each of the following steps:(a) applying an 
antimicrobial dentifrice to 
oral cavity surfaces, and(b) rinsing the 
oral cavity with an 
antimicrobial mouthrinse,wherein at least one of steps (a) and (b) is conducted prior to retiring at night. Preferably the 
regimen comprises as step (c) treating interproximal, gingival and subgingival areas of the oral cavity using an interproximal device selected from 
dental floss, floss pick, dental tape, and proxy 
brush, wherein step (c) is conducted immediately before or immediately after one or both of steps (a) and (b).