Novel method of producing strontium ranelate heptahydrate

A technology of heptahydrate and strontium ranelate, which is applied in the field of preparation of strontium ranelate heptahydrate, can solve the difficulties in the formulation of quality standards for raw materials and the preparation of preparations, unstable water content of hydrates, cumbersome preparation methods, etc. problems, to achieve excellent physical and chemical properties, facilitate quality control and drug safety, and achieve the effect of stable water content

A technology of heptahydrate and strontium ranelate, which is applied in the field of preparation of strontium ranelate heptahydrate, can solve the difficulties in the formulation of quality standards for raw materials and the preparation of preparations, unstable water content of hydrates, cumbersome preparation methods, etc. problems, to achieve excellent physical and chemical properties, facilitate quality control and drug safety, and achieve the effect of stable water content

CN100554263CInactive Publication Date: 2009-10-28TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Novel method of producing strontium ranelate heptahydrate
  • Novel method of producing strontium ranelate heptahydrate
  • Novel method of producing strontium ranelate heptahydrate

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Embodiment 1: Preparation of strontium ranelate heptahydrate

[0056] Weigh 400g of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylate tetraethyl ester into the reaction flask, add 3.6L1N sodium hydroxide solution and 3.6L ethanol, heated to reflux, reacted for 4h, kept the pH value above 10 during the reaction, lowered the temperature, filtered, evaporated the filtrate to remove ethanol under reduced pressure, quantitatively added 720ml ethanol to the aqueous solution, and then added 2 times the molar amount of strontium chloride water solution, a solid precipitated. Filter, wash the filter cake layer with water 3 times, drain it, dry it in the air, add 4L of water to reflux, heat filter, wash it 3 times with boiling water, drain it, place it at room temperature, and keep the weight constant to obtain 440g. Loss on drying 19.82%, related substances 0.17%. The XRD pattern of strontium ranelate heptahydrate crystal is shown in the appendix f...

Embodiment 2

[0057] Embodiment 2: Preparation of strontium ranelate heptahydrate

[0058]Weigh 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid tetraethyl ester, add 500g into the reaction flask, add 4.5L1N sodium hydroxide solution and 4.5L ethanol, heated to reflux, reacted for 8 hours, kept the pH value at 13, cooled down, filtered, the filtrate was evaporated to remove ethanol under reduced pressure, 2250ml ethanol was added to the aqueous solution, and then a solution of 2.5 times the molar amount of strontium chloride water was added to precipitate solid. Filter, wash the filter cake layer with water 3 times, drain it, dry it in the air, add 5L of water to reflux, heat filter, wash it 3 times with boiling water, drain it, place it at room temperature, and obtain 560g at constant weight. Loss on drying 19.74%, related substances 0.08%. The XRD pattern of strontium ranelate heptahydrate crystal is shown in the appendix figure 1 .

Embodiment 3

[0059] Embodiment 3 pharmaceutical composition

[0060] Prepare 1000 bags of granule prescriptions, each containing 1g of active ingredient

[0061] The crude drug 1246g of embodiment 1

[0062] Lactose 1800g

[0063] Microcrystalline Cellulose 1500g

[0064] Xylitol 100g

[0065] Sorbitol 100g

[0066] Methylcellulose 200g

[0067] Flavor 100g

[0068] Preparation Process:

[0069] Pass the main ingredient and auxiliary materials through a 200-mesh sieve respectively. Fully mix the excipients first, then weigh the prescribed amount of excipients and mix them fully with the main drug. Use 10% pvp water to make soft material, granulate with 20 mesh sieve, dry at 50°C, granulate with 20 mesh sieve, sieve out fine powder, and pack.

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Abstract

The invention relates to a method for preparing strontium ranelate heptahydrate. The product prepared by the method has a water content of 19.0-20.4%, and related substances are less than 0.5%. The strontium ranelate heptahydrate prepared by the method is stable at room temperature, the difference in water content between batches is small, and its water content, content and related substances remain unchanged when stored in a natural environment for a long time. It is characterized in that: 1. 2-[N, N-bis(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid tetraester (b) in an appropriate amount of sodium hydroxide hydroalcohol Reflux the solution for 5 to 6 hours, and keep the pH value above 10 during the hydrolysis process; ② Then add 20-60% ethanol, and then directly add 2-2.5 times the molar amount of strontium chloride aqueous solution, precipitate crystals, filter, and dry; ③ Add water Reflux, remove a small amount of salt wrapped in the crude product, heat filter, and collect the product. The invention also discloses a pharmaceutical composition containing strontium ranelate heptahydrate, which is used for treating postmenopausal women's osteoporosis.

Description

technical field [0001] The present invention relates to a new preparation method of strontium ranelate heptahydrate and a pharmaceutical composition containing it. The compound has activity in the treatment of osteoporosis in postmenopausal women. Background technique [0002] The structural formula of strontium ranelate heptahydrate is as follows: [0003] [0004] Strontium ranelate heptahydrate chemical name: [0005] 3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano, strontium salt(1:2)heptahydrate [0006] That is, 5-[di(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiophene acetate distrontium salt heptahydrate, which has very valuable pharmacological activities, especially in anti-osteoporotic properties On the one hand, it can both inhibit bone resorption and promote bone formation, making this compound useful in the treatment of osteoporosis in postmenopausal women. [0007] EP0415850 has described the preparation and therapeutic use of stront...

Claims

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Application Information

Patent Timeline
28 Oct 2009
Publication
CN100554263C
IPC
C07D333/38; A61K31/381; A61P19/10
Inventors
黄汉忠; 李树军