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Synthesis method of strontium ranelate and hydrate thereof

A technology of strontium ranelate and a synthetic method, which is applied in the direction of organic chemistry, can solve the problems of many impurities, low product purity, high production cost, etc., and achieve the effect of improving purity, increasing yield and purity, and low production cost

Active Publication Date: 2010-08-25
浙江东亚药业股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the reaction time of this method is longer, more impurities are generated, the product purity is lower, and the production cost is larger

Method used

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  • Synthesis method of strontium ranelate and hydrate thereof
  • Synthesis method of strontium ranelate and hydrate thereof
  • Synthesis method of strontium ranelate and hydrate thereof

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Abstract

The invention provides a synthesis method of strontium ranelate and a hydrate thereof, belonging to the technical field of pharmaceutical synthesis. The synthesis method of the strontium ranelate and the hydrate thereof comprises the steps of reacting ranelate ester (II) with a water solution of an inorganic base under the catalysis of a quaternary ammonium salt in an organic solvent, decoloring, regulating the pH value to a certain range and adding strontium chloride to obtain one of the strontium ranelate and the hydrate thereof. The invention has the advantages that the final product strontium ranelate or the hydrate thereof has high purify and content and can satisfy the requirement of using the strontium ranelate or the hydrate thereof as a pharmaceutical active ingredient.

Description

Synthetic method of strontium ranelate and hydrate thereof technical field The invention relates to a synthesis method of strontium ranelate and a hydrate thereof, belonging to the technical field of medicine synthesis. Background technique Strontium ranelate (Strontiumranelate), chemical name: 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiophene acetate distrontium, molecular formula is: C12H6N2O8SSr2, molecular structural formula such as formula (I ) as shown: Strontium ranelate is primarily used to reduce the risk of vertebral fractures (with or without fragility fractures at baseline) and hip fractures in postmenopausal women with osteoporosis. The drug can both inhibit bone resorption and promote bone formation (promoting bone formation is the most valuable way to treat osteoporosis), and has a positive effect on reducing the risk of fracture and enhancing bone strength and bone density (compared with other placebos). It can reduce the risk of vertebral frac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D333/38
Inventor 李日生何小鹏王海平池正明
Owner 浙江东亚药业股份有限公司
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