Medicinal composition containing strontium fuminate and vitamin D

A technology of strontium ranelate and vitamins, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of patients forgetting, complicated taking methods, and reduced compliance, and achieve convenient drug use and promote calcium Absorption, promoting the effect of bone calcification

Inactive Publication Date: 2006-08-30
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when taking strontium ranelate, taking vitamin D in addition, the taking method is more complicated, and it is

Method used

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  • Medicinal composition containing strontium fuminate and vitamin D

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1——compound strontium ranelate vitamin D chewable tablet

[0026] Strontium ranelate 1000g

[0027] Vitamin D3 200,000 IU

[0028] Mannitol 500g

[0029] Aspartame 30g

[0030] 10% starch slurry appropriate amount

[0031] Sweet Orange Flavor 50g

[0032] Micronized silica gel 10g

[0033] Made into 1000 pieces

[0034] The above prescription amounts of strontium ranelate, vitamin D3, mannitol and aspartame are mixed evenly in equal amounts, and 10% starch slurry is made into a soft material, which is then granulated, dried, granulated, and then mixed with essence and micro-powdered silica gel Evenly, and then pressed into pieces.

[0035] Application: the pharmaceutical composition obtained above is applied to treat postmenopausal osteoporosis and reduce the risk of vertebral and hip bone fractures. Chew orally, once a day, 2 tablets at a time, preferably two hours after eating and before going to bed.

Embodiment 2

[0036] Embodiment 2——compound strontium ranelate vitamin D granules

[0037] Strontium ranelate 2000g

[0038]Vitamin D3 800,000 IU

[0039] Mannitol 1200g

[0040] Dextrin 400

[0041] Aspartame 35g

[0042] Make 1000 bags

[0043] After mixing the raw and auxiliary materials in the above prescription amount evenly, granulate with water or 20% ethanol solution, dry the granules, granulate, then sieve into granules of appropriate size, and pack them into bags.

[0044] Application: the pharmaceutical composition obtained above is applied to treat postmenopausal osteoporosis and reduce the risk of vertebral and hip bone fractures. Take orally, once a day, 1 bag at a time, preferably two hours after eating and before going to bed. Stir each sachet with water before use, and then take it.

Embodiment 3

[0045] Example 3—Composite packaging of strontium ranelate single-component preparation and vitamin D single-component preparation

[0046] (1) Preparation of strontium ranelate chewable tablets

[0047] Strontium ranelate 1000g

[0048] Lactose 500g

[0049] Glycyrrhizin 30g

[0050] Sodium cyclamate 15

[0051] 5% polyvinylpyrrolidone 50% ethanol solution appropriate amount

[0052] Apple essence 50g

[0053] Talc powder 20g

[0054] Made into 1000 pieces

[0055] The above prescription amount strontium ranelate, lactose, glycyrrhizin and sodium cyclamate are mixed evenly, 5% polyvinylpyrrolidone 50% ethanol solution is made into a soft material, and then granulated, dried, granulated, and then mixed with apple essence and The talcum powder is mixed evenly, and then compressed into tablets.

[0056] (2) Preparation of strontium ranelate particles

[0057] Strontium ranelate 2000g

[0058] Mannitol 1200g

[0059] Dextrin 400

[0060] Aspartame 35g

[0061] Make 1...

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PUM

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Abstract

A composite medicine and its packed composition for treating the osteoporosis of the woman after manopause contains strontium ranelate or its hydrate, VD and pharmacologically acceptable additives proportionally.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compound preparations, in particular to a pharmaceutical composition containing strontium ranelate and vitamin D and a composite packaging composition thereof. The present invention provides sufficient vitamin D nutritional supplements for postmenopausal women suffering from osteoporosis. Background technique [0002] Osteoporosis is a common disease that is easily overlooked by people. It is characterized by damage to the microstructure of bone tissue, a constant decrease in bone mineral composition and bone matrix, bone thinning, a decrease in the number of bone trabeculae, and bone fragility. A disease of systemic bone metabolism disorder that increases and increases the risk of fracture. Osteoporosis patients range from low back pain and limb weakness to hunched back and bone pain in severe cases. The direct harm is that the incidence of fractures is significantly increased. In particular, femo...

Claims

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Application Information

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IPC IPC(8): A61K31/381A61K31/59A61K9/20A61K9/48A61K9/14A61P19/10
Inventor 赵小萍邓杰牟才华樊斌
Owner CHONGQING PHARMA RES INST
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