The invention discloses a detoxification capsule and a preparation method thereof. The preparation method comprises the following steps: I, smashing lycium barbarums, astragalus membranaceus, ginsengs, aloe and folium ginkgo, soaking the mixture with anhydrous ethanol, refluxing and heating the solution, filtering the solution to prepare an ethanol extracting solution I, then refluxing and heatinga filter cake again, filtering the solution to prepare an ethanol extracting solution II, and spinning and drying the ethanol extracting solutions I and II till no solvent exists, so as to obtain a traditional Chinese medicine extract; II, smashing and screening carrots, sweet potatoes and soybeans, and drying mixture to prepare a dietary material; III, stirring the traditional Chinese medicine extract, the dietary material, organic calcium, magnesium stearate, tea polyphenol, rice flour, maltodextrin and unsaturated fatty acid till the mixture becomes paste; IV, performing high-pressure homogenization, drying, re-smashing and screening on the mixture in Step III to prepare micro-spherical granular drug powder, and putting the powder into an empty capsule to prepare the detoxification capsule; V, polishing and packaging the capsule. By adoption of a traditional Chinese medicine formula, the detoxification capsule disclosed by the invention has effects of benefiting qi for activating blood circulation, relaxing the bowels and clearing away toxins, achieves both detoxification and tonification and does not have any side effects; furthermore, the production and preparation process issimple, and the preparation raw materials are low in cost, so that the detoxification capsule is convenient to popularize.