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Pharmaceutical composition for treating calcium deficiency, and preparation thereof

A composition and medicine technology, applied in the field of preparations that can treat calcium deficiency, can solve the problems of calcium carbonate being insoluble in water, high toxicity, slow absorption and the like

Inactive Publication Date: 2011-10-19
KUNMING BANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Domestic and foreign medical circles agree that long-term calcium deficiency in the human body is the main cause of osteoporosis, hyperosteogeny, and rickets. For this disease, calcium supplementation is currently the main method of prevention and treatment. The existing calcium supplementation in China is active. Calcium is ionized calcium, calcium gluconate, calcium lactate, calcium carbonate, etc. These calcium supplements are used to treat osteoporosis and hyperplasia, but there are the following problems: First, some calcium supplements are not easily absorbed by the body, such as oysters, mussels, etc. The shell is used as the raw material and calcined at high temperature to make a calcium mixture. Its main components are calcium oxide, calcium hydroxide and a small amount of calcium carbonate. These inorganic calcium are not easy to be absorbed by the human body, and their toxicity is relatively high.
At present, most calcium supplements or nutrients use calcium carbonate and vitamin D. Calcium carbonate is insoluble in water, and part of it becomes ionized calcium under the action of gastric acid, which is slow to absorb and has a large amount of loss.

Method used

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  • Pharmaceutical composition for treating calcium deficiency, and preparation thereof
  • Pharmaceutical composition for treating calcium deficiency, and preparation thereof
  • Pharmaceutical composition for treating calcium deficiency, and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 (tablet or film-coated tablet)

[0020] Vitamin D 3 5mg

[0021] Calcium acetate 200g

[0022] Microcrystalline Cellulose 42.5g

[0023] Carboxymethyl Starch Sodium 5g

[0024] Magnesium Stearate 2.5g

[0025]

[0026] Makes 1000 pieces

[0027] Preparation method: vitamin D 3 , calcium acetate, and microcrystalline cellulose, mixed evenly, granulated, granulated, added magnesium stearate, sodium starch glycolate, mixed evenly, pressed into tablets or coated with film according to conventional coating operations, to obtain. Trial-manufactured three batches, the average tablet weight was 0.2489-0.2507g / tablet, containing vitamin D 3 4.8-5.2ug / tablet, containing calcium acetate 0.192-0.217g / tablet, and other indicators are in line with the requirements of Chinese Pharmacopoeia tablets. This product is used for the treatment of calcium deficiency, three times a day, 1 tablet each time, after 3 days of continuous use, the symptoms of calcium d...

Embodiment 2

[0028] Embodiment 2 (capsules)

[0029] Vitamin D 3 10mg

[0030] Calcium acetate 150g

[0031] Starch 100g

[0032] Magnesium stearate 1.2g

[0033]

[0034] Makes 1000 capsules

[0035] Preparation method: vitamin D 3 , calcium acetate, starch, and magnesium stearate are mixed evenly, the content is tested, and hollow capsules are filled to obtain final product. Trial-manufactured three batches, the average loading was tested to be 0.2437-0.2518g / capsule, containing vitamin D 3 9.8-10.2ug / capsule, containing calcium acetate 0.145-0.161g / capsule, and other indicators are in line with the requirements of Chinese Pharmacopoeia capsules. This product is used for the treatment of calcium deficiency, three times a day, 1 capsule each time, after 3 days of continuous use, the symptoms of calcium deficiency can be significantly improved.

Embodiment 3

[0036] Embodiment 3 (granule)

[0037] Vitamin D 3 5mg

[0038] Calcium acetate 600g

[0039] Sucrose 1500g

[0040] Lactose 900g

[0041]

[0042] Make 1000 bags

[0043] Preparation method: vitamin D 3 , calcium acetate, sucrose powder, and lactose are mixed evenly, and 40% ethanol is used as a wetting agent to make soft materials, granulate, dry at 70±10°C, granulate, and pack separately. Trial-manufactured three batches, the average loading amount was 2.903-3.108g / bag after testing, containing vitamin D 3 4.7-5.2ug / bag, containing calcium acetate 0.551-0.654g / bag, other indicators are in line with the requirements of Chinese Pharmacopoeia granules. This product is used to treat calcium deficiency, once a day, 1 bag each time, after 3 days of continuous use, the symptoms of calcium deficiency can be significantly improved.

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Abstract

A pharmaceutical composition for treating calcium deficiency, and preparation thereof. The invention relates to a pharmaceutical composition for calcium supplement, and also relates to preparation of the pharmaceutical composition. The pharmaceutical composition is prepared from calcium acetate and vitamin D3 as main raw materials. The main raw materials comprise specifically 1 part of vitamin D3, 10000 to 200000 parts of calcium acetate and 10000 to 2000000 parts of auxiliary materials. The pharmaceutical composition has the advantages that a formula of the pharmaceutical composition is scientific and reasonable; calcium acetate is utilized for calcium supplement and vitamin D3 is utilized for improvement of calcium and phosphorus absorption in bodies thus blood calcium and blood phosphorus levels reach to saturation degrees; the pharmaceutical composition promotes growth and bone calcification, and improve dental health; and through direct supplement of calcium and promotion of calcium absorption, the pharmaceutical composition realizes effects of treating and preventing diseases caused by calcium deficiency.

Description

technical field [0001] The invention relates to a calcium supplement product, in particular to a preparation capable of treating calcium deficiency. Background technique [0002] Domestic and foreign medical circles agree that long-term calcium deficiency in the human body is the main cause of osteoporosis, hyperosteogeny, and rickets. For this disease, calcium supplementation is currently the main method of prevention and treatment. The existing calcium supplementation in China is active. Calcium is ionized calcium, calcium gluconate, calcium lactate, calcium carbonate, etc. These calcium supplements are used to treat osteoporosis and hyperplasia, but there are the following problems: First, some calcium supplements are not easily absorbed by the body, such as oysters, mussels, etc. The shell is used as the raw material and calcined at high temperature to make a calcium mixture. Its main components are calcium oxide, calcium hydroxide and a small amount of calcium carbonate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/593A61K31/19A61P19/10A61P19/08A61P1/02
Inventor 王冰郑光明张永胜刘晓凯杜元英
Owner KUNMING BANGYU PHARMA
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