Growth factor loaded bacterial cellulose/biological ceramic composite membrane

Abstract

The invention discloses a growth factor loaded bacterial cellulose / biological ceramic composite membrane and a preparation method thereof. According to the composite membrane, a bacterial cellulose membrane is used as a basal body, growth factors are loaded on the surface of the bacterial cellulose membrane in a gel depositing and coating manner, and then a biological ceramic membrane is coated onto the surface through an electrostatic spinning technique so that the growth factor loaded bacterial cellulose / biological ceramic composite membrane is obtained. The bacterial cellulose membrane andthe biological ceramic membrane both have a nanometer fiber structure, so that the growth factor loaded bacterial cellulose / biological ceramic composite membrane can be used for materials for tissue repair, and has ample contact space with the cell environment of damaged tissue. Besides, the growth factor loaded bacterial cellulose / biological ceramic composite membrane has favorable effect of maintaining activity of the growth factors, the releasing speed of the growth factor can be controlled through controlling the degradation speed of the composite membrane, and the growth factor loaded bacterial cellulose / biological ceramic composite membrane has favorable application value in the tissue repair respect of promoting tissue division and cell regeneration and the like.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a bacterial cellulose / biological ceramic composite membrane loaded with growth factors and a preparation method thereof. Background technique [0002] Bone defect caused by trauma, tumor, etc. has become a common clinical disease at present. At present, the use of tissue engineering to repair bone defect has become a hot spot, and the tissue engineering scaffold materials used for bone tissue defect repair are mostly concentrated in the use of biopolymers. Composites of materials and ceramic particles, but simple composite materials have the problem of low biological activity. It is one of the research directions of tissue engineering to obtain higher activity of composite tissue engineering materials by loading growth factors; [0003] At present, tissue repair materials loaded with growth factors have been extensively studied. Growth factor loading can regulate the...

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Problems solved by technology

[0008] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a growth factor-loaded bacterial cellulose / bioceramic composite membrane, which has good biocompatibility and can effectively maintain the biological activity of bone repair growth factors, The repair material applied to bone defect tissue solves the problem of poor mechanical strength of bone repair bioceramic membranes; at the same time, the composite membrane can effectively control the release rate of growth factors, which solves the problem of easy growth factors in the current bone tissue repair materials loaded with growth factors. Deactivation and difficulty in controlling loading and release rates

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