The invention provides an
anticoagulant and antibacterial indwelling needle sleeve
pipe and its preparation method. The
anticoagulant and antibacterial indwelling needle sleeve
pipe includes an indwelling needle sleeve
pipe and an
anticoagulant and
antibacterial coating grafted on the indwelling needle sleeve pipe through photo
initiation. The
coating includes
heparin sodium and
hydrogen abstraction type
quaternary ammonium salt with the structure shown in the formula I. A
hydrogen extraction and recombination reaction occurs between
hydrogen abstraction type
quaternary ammonium salt, the surface of an indwelling needle sleeve pipe base body and
heparin molecules, the adhesion property of the
coating is thus very high, the adhesion stability is good, and the
coating has high universality and practicability; the anticoagulant and antibacterial indwelling needle sleeve pipe has non-release type anticoagulant and antibacterial effects, during the sleeve pipe penetration, transfusion,
blood flow scouring and other processes, components of the coating are not dissociated and do not come off, the anticoagulant and antibacterial effects are lasting, and the risk that
quaternary ammonium salt leached out through dissociation enters veins and thus general
toxicity is caused is reduced. The formula I is shown in the description, wherein R is selected from chemical structures (shown in the description) or chemical structures (shown in the description), R1 and R2 are independently selected from H or C1-C4
alkyl groups, R3 is selected from C8-C16
alkyl groups, and X- is selected from Cl-, Br- or I-.