The utility model discloses a printing flexible packaging bag with a waterproof function. The printing flexible packaging bag comprises a packaging bag body, a bonding piece is bonded on the surface of the packaging bag body, a winding plate is bonded on the surface of the bonding piece, a groove is formed in the surface of the winding plate, a spring is welded in the groove, a clamping plate is welded at the other end of the spring, and the clamping plate is located in the groove. According to the printing flexible packaging bag with the waterproof function, a bonding piece is bonded to the surface of the packaging bag body, a winding plate is bonded to the surface of the bonding piece, meanwhile, a groove is formed in the surface of the winding plate, a spring is welded to the interior of the groove, and meanwhile a clamping plate is welded to the other end of the spring; at the moment, under the springback of the spring, the clamping plate can clamp and fix the packaging bag wound on the winding plate, the sealing of the device can be reinforced through the clamping plate and the winding plate, the sealing position cannot be easily opened, and the device is very convenient to use.