Surface coating polymer, and preparation method and application thereof

A surface coating and polymer technology, applied in the application of anti-bacterial adhesion functional materials, in the field of surface coating polymers, it can solve the problems of easy falling off and low safety of the coating, and achieve excellent antibacterial effect and not easy to fall off. , the effect of strong adhesion

Inactive Publication Date: 2019-07-26
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of method is simple and practical, it still has the disadvantages that the coating is easy to fall off and the safety is low.

Method used

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  • Surface coating polymer, and preparation method and application thereof
  • Surface coating polymer, and preparation method and application thereof
  • Surface coating polymer, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] The preparation of embodiment 1 pentafluorophenol acrylate

[0087] M1 # monomer

[0088] Synthesis: Add pentafluorophenol, potassium carbonate and refined THF solvent into a round bottom flask; dissolve acryloyl chloride in refined THF, stir evenly at room temperature and then transfer to a constant pressure dropping funnel; among them, pentafluorophenol, The molar ratio of potassium carbonate and acryloyl chloride is 1:8:8. Put the round-bottomed flask into a low temperature and constant temperature stirring reaction bath at -10°C, add the acryloyl chloride solution dropwise into the round-bottomed flask, and react at constant temperature for 6 hours. After the reaction was stopped, the inorganic solids were removed by centrifugation, and the solvent THF was removed by rotary evaporation; dichloromethane and water were added to the mixture obtained by rotary evaporation for extraction, and the extracted lower layer liquid was rotary evaporated again to obtain the ...

Embodiment 2

[0096] Preparation of embodiment 2 surface coating polymer

[0097] Typically, the RAFT random copolymerization is carried out by using the pentafluorophenol acrylate prepared in Example 1 as the first monomer and 2-methacryloyloxyethyl phosphorylcholine as the second monomer. When the zwitterion of the second monomer is replaced by a sulfobetaine group, a carboxybetaine group, or a substituent group thereof, the polymerization process is roughly the same as that in this embodiment.

[0098] The first monomer pentafluorophenol acrylate, the initiator azobisisobutyronitrile (AIBN), the chain transfer agent 2-cyano-2-propylbenzodisulfide, the second monomer 2-methacryloyloxy Ethyl phosphorylcholine (MPC) was dissolved in purified methanol at a molar ratio of 26.67:0.2:1:40, added into a Schlenk bottle, and reacted in an oil bath at 70°C for 24 hours after three freeze-thaw cycles. After the reaction, the crude product was precipitated with acetone and separated, and purified by...

Embodiment 3

[0101] Antibacterial adhesion performance of embodiment 3 surface coating polymer

[0102] Substrate surface is immersed in the solution of the surface coating polymer that prepares in embodiment 2, obtains antibacterial adhesion coating, and the antibacterial adhesion property of coating has been tested, specifically as follows:

[0103] Prepare two planar PVC substrates of 5cm × 3cm, one PVC substrate surface is coated with the surface coating polymer prepared in embodiment 2, and is recorded as PVC-TC spline; the other is compared as a blank sample, Denoted as PVC-ctr spline.

[0104] The anti-bacterial adhesion performance test is carried out according to the following steps:

[0105] Place the PVC sample strip in the E. coli bacterial liquid, incubate it in a constant temperature shaking box at 37°C for 48 hours, take out the sample strip, and wash it with sterile PBS (phosphate buffer saline, pH=7.2-7.4) for 9 times to remove pseudo-adherent bacteria , then put the sampl...

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PUM

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Abstract

The invention relates to a surface coating polymer, and a preparation method and application thereof. The surface coating polymer comprises a random copolymer of a structural unit containing catecholgroups and a structural unit containing zwitterionic groups; and in the random copolymer, the molar ratio of the structural unit containing the zwitterionic group to the structural unit containing thecatechol group is 50-280: 70-430. The surface coating polymer simultaneously contains the repetition structural unit containing the zwitterionic group and the repetition structural unit containing the catechol group, the excellent antibacterial property of the zwitterionic group and the good adhesion property of the catechol group are combined by the polymer, and the polymer has strong adhesion to the surface of a substrate, has good adhesion stability, is not easy to fall off, and has excellent antibacterial property and a bacteria adhesion resisting function.

Description

technical field [0001] The invention relates to the fields of synthetic polymer materials and biomedical polymer materials, in particular to surface coating polymers, their preparation methods and their application in anti-bacterial adhesion functional materials. Background technique [0002] The adhesion, proliferation and formation of biofilm (biofilm) of bacteria on the surface of medical devices and implants in the body will lead to infection and a series of complications in patients, and even endanger the lives of patients in severe cases. According to statistics, the rate of nosocomial bacterial infection during the 48-72 hours of hospitalization is 6-12%, and the growth of bacteria on the surface of medical devices is the most important cause of nosocomial infection. [0003] In order to solve the above problems, endowing the surface of medical devices with antibacterial properties has become an effective way. The methods are mainly divided into two types: one is to c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F230/02C08F220/22C08F2/38C08F8/32C09D143/02C09D5/14A61L31/10A61L31/16
CPCA61L31/10A61L31/16A61L2300/216A61L2300/404A61L2300/606C08F2/38C08F8/32C08F230/02C09D5/14C09D143/02C08F220/22C08L43/02
Inventor 白莹赵彩玲黄绮婷蔡绮幸沈宣任全大萍
Owner SUN YAT SEN UNIV
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