The invention belongs to the technical field of aerospace sealing materials, and particularly discloses highly-oil-repellenting highly-waterproof seamless polytef expansion sheet materials and a preparation method thereof. The preparation method comprises the following steps: mixing materials, performing, pushing and pressing, calendaring, drying, puffing, sizing, thermocompression bonding, surface chemical processing, and the like. The highly-oil-repellenting highly-waterproof seamless polytef expansion sheet materials which are prepared and obtained by the method have good chemical stability, electrical insulating property, and self-lubrication performance, overcome the cold flow property (creepage) of pure polytef sealing materials, cannot become hard or crisp ( good elasticity) with the time, can bear the temperature range of -65 DEG C - +177 DEG C, are applicable to flat seal of various shapes, and are indispensable and important materials in frontier science and modern industries.