The invention provides a method for producing an antiseptic oriented strand board through full-eucalyptus leftover materials. The method comprises the procedures of material preparing, drying, peel and impurity removing, sorting and storing, surface layer and core layer gluing, classified paving, preheating press forming, sanding facing and the like. A surface layer is coated with an isocyanate wood dust powder composite adhesive, a core layer is coated with an antiseptic composite urea-formaldehyde resin adhesive, and core layer wood shavings are of three-layer structures including a core layer middle layer, a core layer upper surface layer and a core layer lower surface layer. The core layer middle layer is longitudinally laid, and the core layer upper surface layer, the core layer lower surface layer and the surface layer are transversely laid. According to the oriented strand board prepared through the method, the static bending intensity in the parallel direction ranges from 34 MPa to 38 MPa, and the parallel elasticity modulus ranges from 4,610 MPa to 4,780 MPa; and the vertical elasticity modulus ranges from 1,500 MPa to 1,774 MPa, the water absorption thickness swelling rate in 24 h ranges from 11% to 16%, and the vertical nail holding force reaches up to 89,000 N. Meanwhile, through adding of an antiseptic agent, the problem that panels are prone to suffering from corrosion of wood-destroying fungi, moulds and white ants is thoroughly solved, and the service life of the panels is prolonged.