115 results about "Enteric coated pellets" patented technology

The invention relate to an enteric-coated pellet preparation of proton pump inhibitor and a preparation method thereof. The enteric-coated pellet preparation of proton pump inhibitor provided by the invention is composed of a blank pellet core, a drug-loaded layer, isolating layers (I) and (II) and an enteric-coated layer, wherein both the drug-loaded layer and the isolating layer (I) contain water soluble inorganic bases, and the base used in the drug-loaded layer contains sodium hydroxide and another water soluble inorganic base which can form buffer with sodium hydroxide in a water solution and the pH of which is in an alkaline environment of 11-12 (excluding 11). The enteric-coated pellet of proton pump inhibitor provided by the invention successfully solves the technical problems of the existing enteric-coated pellet preparation of proton pump inhibitor, and is a superior preparation with high drug loading efficiency, good anti-acid effect, high release rate, good repeatability, high bioavailability and good stability.

The invention discloses a probiotic pellet preparation and a preparing method thereof. The preparation is a pellet which consists of a probiotic pellet core and an enteric coating layer wrapping the probiotic pillet core. The preparing method comprises the following steps: (1) evenly mixing probiotics and excipients, adding solvents and stirring the mixture to prepare wet material; (2) extruding, cutting and rounding the wet material prepared in step (1) to prepare a spherical wet granule and drying and selecting the probiotic pellet core; and (3) spraying an enteric coating material solution to the probiotic pellet core and drying to obtain an enteric coated pellet core. The probiotic pellet preparation prepared in the method has high intestinal colonization rate and reliable curative effect after being taken orally.

The invention discloses dimethyl fumarate enteric-coated pellets and a preparation method thereof. Each enteric-coated pellet comprises a blank pellet core, an active drug layer wrapping the blank pellet core, an isolating layer, an inner layer enteric-coated coating layer and an outer layer enteric-coated coating layer from inside to outside. The enteric-coated pellets are simple in process, complete in release, good in reproducibility, small in gastrointestinal tract irritation, safe and effective.

The invention provides an ilaprazole enteric coated tablet and a preparation method thereof. The ilaprazole enteric coated tablet comprises enteric coated pellets and a pharmaceutically-acceptable tablet auxiliary material, wherein each enteric coated pellet comprises a pellet core, an isolating layer and an enteric coated layer; and the pellet core comprises ilaprazole or a pharmaceutically-acceptable salt thereof and a stabilizing agent. The enteric coated pellet tablet made from ilaprazole has high acid resistance; in a prescription, barrier substances such as an acid resisting agent, a surfactant, an organic solvent, a hydrophobic substance and the like are not contained, so that the health and safety of a human body are better facilitated; in the preparation method, an organic solvent is not used, so that operation is easy, and active substances are released quickly and stably; and moreover, the pellets in the tablet can be widely and uniformly distributed into an intestinal tract after administration, a dosage is poured out in a scatter way, and the distribution area of a medicament on the surface of the intestinal tract is increased, so that the stimulation of the medicament on the intestinal tract can be reduced or eliminated, and the bioavailability of the medicament is enhanced.

The invention discloses a doxycycline hyclate enteric-coated pellet which comprises the following components in percentage by weight from inside to outside: 48-58 blank core pellet, 35-40 medicinal layer and 4-13 enteric-coated layer. The invention also discloses a method for preparing the doxycycline hyclate enteric-coated pellet. The doxycycline hyclate enteric-coated pellets prepared by the method are filled into a capsule, and an obtained enteric-coated preparation has the advantages of increased contact area with the intestinal tract, high bioavailability, good stability, steady release in vitro and vivo, no influence by gastrointestinal peristalsis and food intake, uniform absorption, smaller difference of bioavailability among individuals, and the like.

The invention discloses esomeprazole enteric-coated tablets and a preparation method thereof. The formula of the tables comprises esomeprazole magnesium, and an inert pellet core, a binder, a dispersant and a disintegrant which are used for tablet preparation. The preparation method comprises spraying and coating esomeprazole magnesium on the blank pellet core, coating an isolating layer and an enteric coated layer, making into enteric-coated pellets, and making into the required enteric-coated preparation by using the specific tablet adjuvants and tabletting method. The esomeprazole enteric-coated tablets and the preparation method thereof disclosed by the invention have the characteristics that by adopting specific tablet preparation method, the shortcoming that the enteric coated layers of the enteric-coated pellets are easy to be broken during tabletting process to affect the acid resistance of esomeprazole enteric-coated tablets is effectively overcome.

The invention discloses esomeprazole magnesium enteric capsules and a preparation method thereof. Esomeprazole magnesium is prepared into enteric coated pellets, and the enteric coated pellets are filled into gastric coated capsules. Each enteric coated pellet consists of an empty pellet core, a medicine carrying layer, two isolating layers, an enteric coated layer and a film coating layer. In order to guarantee stability of medicines, alkaline materials are added in the empty pellet cores; alkali stabilizers and antioxidant are added in the medicine carrying layer; and a high-alkalinity modifier and a low-alkalinity modifier are respectively added in the two isolating layers of each enteric coated pellet. In order to guarantee a dissolution effect, surfactant is added in the enteric coated layers; and stability of products is improved owing to the film coating layers wrapping the outer layers of the enteric coated pellets. Owing to optimized formulation and technology of the pellets, smoothness of a technology is improved, work efficiency is also improved, coating time is shortened, consumption of labor and materials is reduced, and production cost is reduced.

A solid, rapidly gelling oral pharmaceutical dosage form, as well as an aqueous formulation prepared thereof, comprising a) an acid sensitive proton pump inhibitor as active ingredient distributed in a multitude of enteric coated pellets, and b) a suspension modifying granulate. Furthermore, the invention relates to an improved process for the manufacture and the use of such formulation in medical treatment, including prevention of gastrointestinal disorders in humans.

The invention relates to a nano zinc oxide enteric-coated pellet and a preparation method thereof. Existing zinc oxide products for preventing and controlling piglet diarrhea are no longer able to meet market demands. The nano zinc oxide enteric-coated pellet sequentially comprises a zinc oxide pellet core, an isolation layer, an enteric layer and a protective layer from inside to outside. The selected zinc oxide raw material is pharmaceutical grade 99% zinc oxide which is subjected to nano treatment or ordinary feed grade zinc oxide with a purity of more than 95%, the zinc oxide particle sizeis below 3,000 mesh, and the nano zinc oxide enteric-coated pellet is prepared from the raw materials in parts by mass: 30-90 parts of the nano zinc oxide pellet core, 0-40 parts of the sum of the isolation layer and the protective layer and 10-30 parts of the enteric layer. According to the nano zinc oxide enteric-coated pellet and the preparation method thereof, excessive zinc is avoided, zincpollution is reduced, the dosage is small, zinc emissions in animal faeces are greatly reduced, soil pollution is prevented, and environmental protection is achieved.

The invention relates to an azithromycin enteric-coated pellet capsule and a preparation method thereof. The capsule comprises azithromycin mixed preparation auxiliary material which is loaded into a pellet core to form a pellet pill that is covered by isolation coating material to form an isolation layer and covered by enteric-coated material to form an enteric-coated layer. The invention azithromycin enteric-coated pellet capsule solves the problems in the background technology, can be dissolved and absorbed in intestinal tract, is rapidly and evenly dispersed in the intestinal tract after entering into the intestinal tract, and effectively improves the bioavailability of medicine. The invention also provides the preparation method of the azithromycin enteric-coated pellet capsule.

The invention relates to the technical field of medicines, in particular to a colon-targeted capsule for treating ulcerative colitis and a preparation technology thereof. Capsule contents of the colon-targeted capsule are prepared from 5-10 parts of gastric-dissolved pellets and 10-20 parts of enteric-coated pellets, the gastric-dissolved pellets are prepared from rhizoma atractylodis macrocephalae volatile oil, beta-cyclodextrin, a pill accelerator and the like, the enteric-coated pellets are prepared from coptidis rhizoma, saposhnicovia divaricata, fructus mume extracts, a pill accelerator and a colon-targeted coating material. Accordingly, the colon-targeted capsule is characterized in that the symptoms and the causes are treated, bioavailability is high, different ingredients are released in the stomach and the colon, and the capsule has the advantages that oral administration is safe and convenient, the coating prescription is simple, and industrial production can be conducted. Animal experiments show that the colon-targeted capsule has the obvious therapeutic effect on the ulcerative colitis, the treatment effect of the medium dosage is close to and even superior to the positive control drug SASP, and a brand new preparation is provided for clinically treating the ulcerative colitis.

The invention relates to a preparation method of lumbrokinase enteric-coated pellets, comprising the following steps of: washing fresh live eisenia foetida with purified water, preparing homogenate by a colloid mill, repeatedly freezing and thawing, heating, centrifuging at high speed to obtain supernatant, separating the supernatant by an anion exchange chromatographic column, eluting, concentrating, filtering to obtain a lumbrokinase concentrated solution, mixing the concentrated solution with an adhesive, spraying onto the blank pellet cores to prepare pellets, coating the pellets with enteric coatings, and screening. The raw materials of the enteric-coated pellets prepared by the method dispense with a freeze drying process, thus simplifying the production process and lowering the production cost.