Nano zinc oxide enteric-coated pellet and preparation method thereof

Abstract

The invention relates to a nano zinc oxide enteric-coated pellet and a preparation method thereof. Existing zinc oxide products for preventing and controlling piglet diarrhea are no longer able to meet market demands. The nano zinc oxide enteric-coated pellet sequentially comprises a zinc oxide pellet core, an isolation layer, an enteric layer and a protective layer from inside to outside. The selected zinc oxide raw material is pharmaceutical grade 99% zinc oxide which is subjected to nano treatment or ordinary feed grade zinc oxide with a purity of more than 95%, the zinc oxide particle sizeis below 3,000 mesh, and the nano zinc oxide enteric-coated pellet is prepared from the raw materials in parts by mass: 30-90 parts of the nano zinc oxide pellet core, 0-40 parts of the sum of the isolation layer and the protective layer and 10-30 parts of the enteric layer. According to the nano zinc oxide enteric-coated pellet and the preparation method thereof, excessive zinc is avoided, zincpollution is reduced, the dosage is small, zinc emissions in animal faeces are greatly reduced, soil pollution is prevented, and environmental protection is achieved.

Description

technical field [0001] The invention relates to a nano-zinc oxide enteric-coated sustained-release pellet and a preparation method thereof. Background technique [0002] Recently, many zinc oxide products for the prevention and treatment of diarrhea have appeared on the feed market, including ordinary zinc oxide, zinc oxide granules, nano-zinc oxide, and enteric-coated zinc oxide pellets (coated with zinc oxide). To the role of prevention and treatment of diarrhea. Among them, ordinary zinc oxide is the most used and the most stable. However, due to its large amount of use, according to the current regulations of relevant state departments, it is required to use 1500ppm zinc source preparations. After high dose use, it will cause the following negative effects: [0003] 1. React with gastric acid or acidifier to reduce the adsorption and astringent effect of zinc oxide [0004] 2. High doses of zinc are excreted with feces, causing soil zinc pollution [0005] 3. Antagoni...

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Problems solved by technology

[0004] 2. High doses of zinc are excreted with feces, causing soil zinc pollution

[0007] 5. Fur confusion

[0008] Secondly, zinc oxide particles and nano-zinc oxide appearing on the market, because these types of products are not enteric-coated, they are only processed through simple processes. For example: zinc oxide particles are granulated with ordinary zinc oxide powder, and the particles hardness to reduce the reaction with gastric acid or acidifier; nano-zinc oxide uses its increased specific surface area to reduce the loss in gastric acid; the general usage of such products is about 2000 grams, so it cannot really reduce the zinc oxide. usage to achieve low zinc emissions

[0009] In addition, there are also some enteric-coated zinc oxide pellets (coated with zinc oxide) on the market. Due to the different sources of zinc oxide raw materials and the instability of the coating process, there will be release defects between batches. When unstable batches After the addition of enteric-coated zinc oxide pellets is reduced, the diarrhea rate of piglets will increase significantly, the growth performance will decrease, the feed efficiency will decrease, and the farmers will lose a lot. Therefore, the existing zinc oxide products used to prevent and treat piglet diarrhea can no longer meet the market demand.