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A cartridge for extracting a beverage from a particulate substance contained therein by means of water under pressure, the cartridge comprising: a main body comprising a cup portion and a lid portion, the cup portion comprising a base, a sidewall and a rim opposed to the base, the lid portion being fixedly attached to the rim of the cup portion so as to define an internal volume of the cartridge, the internal volume of the cartridge housing the particulate substance comprised within filtering means for retaining the particulate substance and for percolating fluid substances therethrough, the lid portion comprising a lid port defining a first passage for percolation fluid substances, the base of the cup portion comprising a cup port defining a second passage for percolation fluid substances, wherein the base comprises a plurality of ridges directly formed thereon and protruding towards the internal volume of the cartridge, so as to support the filtering means and the particulate substance and to define a fine canalization between the filtering means and the cup port.

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

An umbrella base is comprised of a body portion containing a power source for powering umbrella lights or electrical devices or appliances used around the umbrella or other furniture accessory held by the base. A power console is provided for use on or above the base to provide connectivity to the power supply.

The improvements proposed in this invention provide a reliable apparatus and method to gasify low rank coals in a class of pressurized circulating fluidized bed reactors termed “transport gasifier.” The embodiments overcome a number of operability and reliability problems with existing gasifiers. The systems and methods address issues related to distribution of gasification agent without the use of internals, management of heat release to avoid any agglomeration and clinker formation, specific design of bends to withstand the highly erosive environment due to high solid particles circulation rates, design of a standpipe cyclone to withstand high temperature gasification environment, compact design of seal-leg that can handle high mass solids flux, design of nozzles that eliminate plugging, uniform aeration of large diameter Standpipe, oxidant injection at the cyclone exits to effectively modulate gasifier exit temperature and reduction in overall height of the gasifier with a modified non-mechanical valve.

Visualization and ablation system variations are described which utilize various tissue ablation arrangements. Such assemblies are configured to facilitate the application of energy delivery, such as RF ablation, to an underlying target tissue for treatment in a controlled manner while directly visualizing the tissue during the bipolar ablation process.

An umbrella base is comprised of a body portion having a billboard surface for advertising a company, organization, products, service or the like. The billboard surface can be provided on a separate removable billboard plate placed on the top of the body portion, which allows the advertising message to be easily changed. In its preferred construction, the body portion has at least one ballast cavity, and preferably multiple ballast cavities, and is constructed in separable parts to permit a selected ballast to be added to the ballast cavities in order to add a desired ballast weight to the umbrella base. The umbrella base can also be provided with casters, including locking casters, so that the umbrella base and its advertising message can be easily moved across a surface from one location to the another.

PCT No. PCT / US98 / 23482 Sec. 371 Date Feb. 7, 2000 Sec. 102(e) Date Feb. 7, 2000 PCT Filed Nov. 4, 1998 PCT Pub. No. WO99 / 26616 PCT Pub. Date Jun. 3, 1999The present invention provides compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of diseases whose treatment benefits from the inhibition of phosphodiesterase (PDE-IV) or Tumor Necrosis Factor (TNF) including asthma, allergic diseases, rheumatoid arthritis, osteoarthritis, septic shock. The compounds provided by this invention have formula (I) wherein R1, R2, R3, R4 are as defined herein.

The invention provides a blowing agent delivery system for introducing a blowing agent into a polymeric foam processing system. The delivery system is designed to discontinuously introduce blowing agent from a continuous source into polymeric material within an extruder. The system, thus, may improve control over blowing agent delivery in discontinuous polymer processing systems such as injection molding or blow molding. In some embodiments, the blowing agent delivery system selectively directs blowing agent flow from the source to the extruder barrel, or through a bypassing passageway. In this manner, blowing agent may be continuously supplied by the source but discontinuously injected into the extruder barrel. During use, the delivery system may cause blowing agent to flow through the bypassing passageway, for example, when the screw stops plasticating polymeric material.

A method of uniformly dispersing a nano powder throughout a micron powder. Ordinary mixing or agitation does not succeed in attaining uniform dispersal: the nano powder agglomerates into microscopic masses. In one form of the invention, a charge of a micron powder, with fifty weight percent of charge of nanopowder is loaded into a ball mill. The mixture is ball milled for less than two hours, at room temperature in a dry condition, and produces a highly uniform distribution of the nano powder throughout the micron powder.

A GaN-based semiconductor light-emitting device includes (A) a first GaN-based compound semiconductor layer 13 having n-type conductivity, (B) an active layer 15 having a multi-quantum well structure including well layers and barrier layers for separating between the well layers, and (C) a second GaN-based compound semiconductor layer 17 having p-type conductivity. The well layers are disposed in the active layer 15 so as to satisfy the relation d1<d2 wherein d1 is the well layer density on the first GaN-based compound semiconductor layer side in the active layer and d2 is the well layer density on the second GaN-based compound semiconductor layer side.

Disclosed are ceramic honeycomb articles, which are composed predominately of a crystalline phase cordierite composition. The ceramic honeycomb articles possess a microstructure characterized by a unique combination of relatively high total porosity of less than 54%, and relatively narrow pore size distribution having a d10 pore diameter of not less than 8 μm, a d90 pore diameter of not greater than 35 μm, and a value of df=(d50−d10) / d50 of less than 0.50. The articles exhibit high thermal durability and high filtration efficiency coupled with low pressure drop across the filter. Such ceramic articles are particularly well suited for filtration applications, such as diesel exhaust filters or DPFs. Also disclosed are methods for manufacturing the ceramic articles of the present invention.

Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top, side and bottom walls defining an inner surface. The entry port is configured to receive the biological solution. The cavity is in communication with the entry port and includes the porous substrate maintained under negative pressure. The container volume is substantially the same as a volume of the porous substrate. The side and bottom walls are configured to promote a laminar flow of the biological solution received through the entry port.

Embodiments of the invention provide analyte sensors having optimized electrodes and / or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

A transtibial patellar tendon bearing (PTB) prosthesis for below the knee amputees is disclosed. The prosthesis includes a socket, and a foot prosthesis attached to a modular shank component using a foot rotator device. Using the rotator device, the foot component of the prosthesis may be smoothly and axially rotated internally or externally ±150° with respect to the shank component about the axis of the shank component. The wide range of axial rotation enables a more even load distribution on the whole lower limb of an amputee and enables an amputee to comfortably assume a wide range of biomechanical positions, such as sitting or kneeling. A recoil spring, having a selectable tension, is positioned within the rotatable component and selectively limits and retains the relative rotation of the upper portion and the lower portions. A locking mechanism selectively prevents rotation when the foot component is engaged.

A freestanding battery separator includes a microporous polymer web with passageways that provide overall fluid permeability. The polymer web preferably contains UHMWPE and a gel-forming polymer material. The structure of or the pattern formed by the gel-forming polymer material and wettability of the UHMWPE polymer web result in a reduction of the time required to achieve uniform electrolyte distribution throughout the lithium-ion battery. In a first embodiment, the gel-forming polymer material is a coating on the UHMWPE web surface. In a second embodiment, the gel-forming polymer material is incorporated into the UHMWPE web while retaining overall fluid permeability. Both embodiments produce hybrid gel electrolyte systems in which gel and liquid electrolyte co-exist.

A head-box for depositing slurry upon a moving web including a main metering roll, a companion roll disposed in closely spaced relation to the metering roll and a vibrating gate which forms a nip between the metering roller and the gate. The nip is arranged to retain a supply of the slurry, and the rolls are driven so slurry retained in the nip progresses over an upper outer peripheral surface of the metering roll to be deposited upon the web. Also, preferably included is a doctor blade disposed in operational relationship to the metering roll for directing the slurry downwardly from the outer metering roll surface to a point above the surface of a carrier for a fiberglass layer upon which the slurry layer is deposited. The vibrating gate and doctor blade may be pivotally mounted to either side of the surfaces of the head-box.

A beverage extraction assembly for application to beverage extraction machines for extracting a beverage from a particulate substance contained in a cartridge, comprising: a support connectable to a water outlet of a beverage extraction machine; a cartridge holder removably mounted on the support for holding a cartridge containing a particulate substance, the cartridge comprising at least a first cartridge port protruding outwardly from its upper surface for receiving water under pressure; the support comprising a water inlet port connectable to the water outlet, for delivering the water to the first cartridge port, the cartridge holder comprising a bottom aperture for providing an escape for the extracted beverage; the water inlet port of the support comprising means for providing a radial fluid-tight seal between the water inlet port and the first cartridge port.

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

A method for treating Attention Deficit / Hyperactivity Disorder (ADHD) in humans and the symptoms associated therewith, inattentiveness, and hyperactivity with impulsivity, using eltoprazine and related compounds is provided.

A beverage extraction assembly for application to beverage extraction machines for extracting a beverage from a particulate substance contained in a cartridge, comprising: a support connectable to a water outlet of a beverage extraction machine; a cartridge holder removably mounted on the support for holding a cartridge containing a particulate substance, the cartridge comprising at least a first cartridge port protruding outwardly from its upper surface for receiving water under pressure; the support comprising a water inlet port connectable to the water outlet, for delivering the water to the first cartridge port, the cartridge holder comprising a bottom aperture for providing an escape for the extracted beverage; the water inlet port of the support comprising means for providing a radial fluid-tight seal between the water inlet port and the first cartridge port.

In a fluid pump and cartridge assembly, a cartridge includes a material inlet port, a material outlet port, and a feed screw. The feed screw delivers fluid to be dispensed from the fluid inlet to the outlet port. The fluid inlet is preferably elongated in a direction along a longitudinal axis of the feed screw to enhance consistency in material flow through the cartridge. The feed screw is preferably driven by a closed-loop servo motor to achieve high-performance dispensing resolution. The assembly is preferably compatible with fixed-z and floating-z cartridges. A optional vented dispense tip, in combination with the fluid pump, allows for repeatable deposit of fillet patterns while maintaining optimal consistency. A dispense controller allows for reverse-compatibility such that the fluid pump of the present invention can be mounted to, and controlled by, conventional pump position controllers.

The present invention relates to novel compositions and methods for delivering substances to target tissues and cells by contacting the targets with delivery systems associated with membranes (e.g., biocompatible or bioerodable membranes). More particularly, the present invention is directed to dendrimer-based methods and compositions for use in disease therapies, wound healing, and generally, improved gene transfection and compound delivery to target cells and tissues in vitro and in vivo.

The disclosure provides embodiments for elasticized members used as closures for garments, such as diapers, jacket cuffs, and similar articles, the elasticized member having an elastic body having an attachment region adapted for attachment of the elastic body to a garment and a fastener positioned on a distal portion of the elastic body, wherein the elastic body is structured to reduce curl along longitudinal edges and corners of the elastic body upon application of tension to the fastener.

The invention discloses a copper-carbon composite material and a preparing method thereof. Natural flake graphite, colloidal graphite, nano graphite, carbon fiber and the like can be selected as a carbon material in the copper-carbon composite material. The preparing method of the copper-carbon composite material includes the steps that firstly, a chemical nickel plating method is used for preparing a nickel plating carbon material; then a chemical copper plating method is used for plating copper on the nickel plating carbon material; and finally, vacuum semi-solid-state low-pressure sintering is conducted on the copper plating carbon material under the copper melting point temperature, and the copper-carbon composite material is prepared. The copper-carbon composite material and the preparing method thereof have the beneficial effects that a layer of even thin nickel plating layer is formed on the surface of carbon through the nickel plating method so as to reduce the wetting angle of the carbon material, the copper plating layer is formed on the surface of the nickel plating carbon material through the copper plating method so that a three-dimensional copper network can be formed by the material in the sintering process, and the bonding strength of a base body is improved through vacuum semi-solid-state low-pressure sintering. The two phases of the base body and the carbon of the copper-carbon composite material prepared through the method are distributed evenly and are well combined, and the good electricity and mechanical properties and the good frictional wear performance are achieved.

Wafer carrier arranged to hold a plurality wafers and to inject a fill gas into gaps between the wafers and the wafer carrier for enhanced heat transfer and to promote uniform temperature of the wafers. The apparatus is arranged to vary the composition, flow rate, or both of the fill gas so as to counteract undesired patterns of temperature non-uniformity of the wafers. In various embodiments, the wafer carrier utilizes at least one plenum structure contained within the wafer carrier to source a plurality of weep holes for passing a fill gas into the wafer retention pockets of the wafer carrier. The plenum(s) promote the uniformity of the flow, thus providing efficient heat transfer and enhanced uniformity of wafer temperatures.

Provided is a composition comprising (a) at least one halogenated compound selected from the group consisting of C3-C5 hydrofluoroolefin, CF3I, and combinations thereof, and (b) an effective stabilizing amount of a sesquiterpene selected from the group consisting of farnesol, farnesene, and mixtures thereof.

A system and method for testing for the presence of antigens in food stuffs permits a user to test food products for the presence of antigens for a given food allergy that the user may have. The system comprises two main components, a base station and a test well. The user places a sample of food into the test well. A macerator homogenizes the food in the test well. Antibodies to a particular antigen are bound to an antigen detector in the test well. The base station includes a cartridge dock which powers the macerator and the antigen detector. Antigen-antibody binding provides a change detectable by the detector, which signals the base station of the presence of a threshold degree of antigen-antibody binding and alerts the user of the presence of the antigen, such as by a visual or audible indicator.