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Colon-targeted capsule for treating ulcerative colitis and preparation technology thereof

A colon-targeting technology for ulcerative colitis, applied in the field of medicine, can solve problems such as inability to reach the ulcer lesion area, unremarkable treatment effect, and safety to be investigated, so as to improve gastrointestinal function, good treatment effect, and patient compliance good sex effect

Active Publication Date: 2018-11-27
苏州玉森新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary decoctions, powders, etc. are not only inconvenient to take, but each dose is large, and after oral administration, the drug has been absorbed or degraded by the whole body before reaching the colon; In the rectum and descending colon, it cannot reach the main ulcer lesion areas such as the transverse colon and ascending colon, which affects the efficacy of the drug
In addition, although acupuncture and moxibustion therapy such as acupuncture, acupoint catgut embedding, and acupoint application have been applied, the therapeutic effect is not significant, individual differences are large, recurrence is easy, and the safety needs to be investigated.

Method used

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  • Colon-targeted capsule for treating ulcerative colitis and preparation technology thereof
  • Colon-targeted capsule for treating ulcerative colitis and preparation technology thereof
  • Colon-targeted capsule for treating ulcerative colitis and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of Atractylodes Rhizome Volatile Oil Cyclodextrin Inclusion Compound

[0050] Take 3mL of Atractylodes macrocephala volatile oil and add an equal volume of absolute ethanol to make a mixed solution of Atractylodes macrocephala volatile oil and ethanol for use; weigh 18g of β-cyclodextrin, dissolve it in 180g of distilled water, stir in a constant temperature water bath at 30°C, and add Atractylodes macrocephala dropwise at the same time The mixed solution of volatile oil and ethanol was stirred at constant temperature for 1.5h, cooled to room temperature, refrigerated at 4°C for 24h, filtered with suction, washed with absolute ethanol three times, 5mL each time, and the obtained precipitate was dried in an oven at 40°C to obtain the dry clathrate.

Embodiment 2

[0051] Example 2 Preparation of Atractylodes Rhizome Volatile Oil Cyclodextrin Inclusion Compound

[0052] Take 3mL of Atractylodes macrocephala volatile oil and add an equal volume of absolute ethanol to make a mixed solution of Atractylodes macrocephala volatile oil and ethanol for use; weigh 24g of β-cyclodextrin, dissolve it in 360g of distilled water, stir in a constant temperature water bath at 40°C, and add Atractylodes macrocephala dropwise The mixed solution of volatile oil and ethanol was stirred at constant temperature for 1 h, cooled to room temperature, refrigerated at 4°C for 24 h, filtered with suction, washed with absolute ethanol three times, 5 mL each time, and the obtained precipitate was dried in an oven at 40°C to obtain the dry clathrate.

Embodiment 3

[0053] Example 3 Preparation of Atractylodes Rhizome Volatile Oil Cyclodextrin Inclusion Compound

[0054] Take 3mL of Atractylodes macrocephala volatile oil and add an equal volume of absolute ethanol to make a mixed solution of Atractylodes macrocephala volatile oil and ethanol for use; weigh 30g of β-cyclodextrin, dissolve it in 600g of distilled water, stir in a constant temperature water bath at 50°C, and add Atractylodes macrocephala dropwise The mixed solution of volatile oil and ethanol was stirred at constant temperature for 2h, cooled to room temperature, refrigerated at 4°C for 24h, filtered with suction, washed with absolute ethanol three times, 5mL each time, and the obtained precipitate was dried in an oven at 40°C to obtain the dry clathrate.

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Abstract

The invention relates to the technical field of medicines, in particular to a colon-targeted capsule for treating ulcerative colitis and a preparation technology thereof. Capsule contents of the colon-targeted capsule are prepared from 5-10 parts of gastric-dissolved pellets and 10-20 parts of enteric-coated pellets, the gastric-dissolved pellets are prepared from rhizoma atractylodis macrocephalae volatile oil, beta-cyclodextrin, a pill accelerator and the like, the enteric-coated pellets are prepared from coptidis rhizoma, saposhnicovia divaricata, fructus mume extracts, a pill accelerator and a colon-targeted coating material. Accordingly, the colon-targeted capsule is characterized in that the symptoms and the causes are treated, bioavailability is high, different ingredients are released in the stomach and the colon, and the capsule has the advantages that oral administration is safe and convenient, the coating prescription is simple, and industrial production can be conducted. Animal experiments show that the colon-targeted capsule has the obvious therapeutic effect on the ulcerative colitis, the treatment effect of the medium dosage is close to and even superior to the positive control drug SASP, and a brand new preparation is provided for clinically treating the ulcerative colitis.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a prescription of a colon-targeted capsule for treating ulcerative colitis and a preparation process thereof. Background technique [0002] Ulcerative colitis (UC), also known as chronic nonspecific ulcerative colitis, is a common autoimmune disease. Its clinical manifestations are mainly digestive system symptoms, including abdominal pain, diarrhea, mucus pus and blood in the stool, and tenesmus. The course of the disease is protracted and difficult to heal, ranging from several months to decades, often recurrent, and severe cases can cause colon cancer. Infection, mental, genetic, immune, environmental and other factors can induce ulcerative colitis. With the acceleration of the pace of life in modern society, the aggravation of survival pressure, and the change of diet structure, the incidence of the disease is increasing year by year. According to statistics, the inciden...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/48A61K9/16A61K9/50A61P1/04A61P1/00A61P29/00A61P37/02
CPCA61P1/00A61P1/04A61P29/00A61P37/02A61K9/1652A61K9/5026A61K9/5047A61K36/238A61K36/284A61K36/718A61K36/736A61K2300/00
Inventor 刘继勇唐晓萌岳小强王婷顾永卫杨盟顾清
Owner 苏州玉森新药开发有限公司
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