514results about How to "Tumor suppression" patented technology

The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a binding agent that can specifically bind to an epitope that comprises both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for the use of such therapeutic compositions in the treatment of cancer.

The invention also provides methods for therapeutically treating a mammal bearing a tumor comprising administering to the mammal an effective amount of a therapeutic composition consisting essentially of a binding agent that specifically binds to an epitope of tumor-associated MUC1, wherein the mammal generates an immune response that comprises an antibody that specifically binds to an epitope of tumor-associated MUC1 that is different from the epitope of tumor associated MUC1 that is specifically bound by the binding agent.

The invention relates to a technology for high-density fermentation of Lactobacillus casei (Lactobacillus casei Zhang) with prebiotic efficacy, which comprises optimal controls on a proliferation culture medium and the condition of a fermentation process, and a technology for preparing high-vitality freeze-dried powder of the strain. With the technology, the freeze-dried powder of the Lactobacillus casei with more than 10<11> cfu per milliliter of viable bacteria can be obtained, and the freeze-dried powder can be directly applied to the preparation and the application of a probiotic hametsz and a probiotic preparation of the strain.

The nutritive layer feed is produced with 17 kinds of material, including corn, soybean dreg, shell powder, beer residue, sea weed, etc. The feed has high content of linoleic acid and the egg has obvious preventing and treating effect on iodine deficiency goiter, hyperthyroidosis, etc. It has high content of vitamin E, can stabilize lipoid in egg to inhibit the formation and diffusion of various kinds of cancer cell, and to possess the functions of inhibiting atherosclerosis, improving cardiac and cerebral vascular diseases, etc.

The invention discloses an antioxidant health care food. The health care food is prepared from the following raw materials in parts by weight: 5-8 parts of hematococcus pluvialis powder and 1-3 parts of grape seed extract. According to the invention, the two antioxidant substances, namely the hematococcus pluvialis powder and the grape seed extract, are combined in the previous proportions to develop the synergistic effect of the hematococcus pluvialis powder and the grape seed extract, and then the antioxidant effect is excellent; in addition, a plurality of effects of the two substances can be developed at the same time. The invention also provides an application of the health care food in preparation of antioxidant and anti-aging products.

The invention relates to the field of liquid milk, in particular relating to a fermented milk beverage containing peanut, lotus root and pawpaw and a production method thereof. On the basis of 100 parts of fermented milk beverage by weight, the fermented milk beverage containing peanut, lotus root and pawpaw comprises: 30-80 parts of liquid milk by weight, 0.004-0.007 part of leaven by weight, 3.5-8.0 parts of sweet substance by weight, 0.2-0.7 part of acidity regulator by weight, 0.1-1.5 parts of stabilizing agent by weight, 1-30 parts of peanut paste by weight, 1-10 parts of lotus root powder by weight, 1-5 parts of pawpaw primary paste by weight and the balance water, wherein the stabilizing agent is composed of thickening agent and/ or emulsifier, and the thickening agent contains 0.1-0.25 part of high acyl pectin and propylene glycol alginate. The product of the invention has refreshing and smooth taste when being drunk and contains special fragrance of peanut, lotus root and pawpaw products. Tests prove that the product has no layering phenomenon or severe fat flotation in the storage and placement process within the 6-month quality guarantee period. Thus, the product of theinvention has favorable stability.

The invention relates to the technical field of Chinese medicament health products, in particular to a capsule with an effect of relieving physical fatigue. To solve the problems of long onset period and expensive price in the prior art, the invention provides a solution scheme that the capsule with the effect of relieving physical fatigue comprises the following raw materials in percentage by weight: 20 to 40 percent of ginkgo extract, 15 to 30 percent of American ginseng extract, 5 to 15 percent of medlar extract, 5 to 15 percent of radix astragali extract, 5 to 15 percent of Indian buead extract, and the balance of auxiliary materials. In the capsule, the traditional Chinese medicaments such as ginkgo, medlar, radix astragali, Indian buead and the like are mixed together with American ginseng to balance organ functions and nutrition, so the capsule obviously improves the anti-fatigue effect, and simultaneously has the advantages of quick response, reasonable price and simple preparation process.

The invention provides a healthy food capable of postponing aging of women, which is prepared from plant extract with estrogen-like effect, Spirulina, collagen powder and plant polyphenol. The healthy food has the functions on caring skin, strengthening body, improving bone density, lowering blood lipid, improving appetite, preventing cancer, resisting fatigue, improving immunity, and can excite young activity and prevent and postpone aging of middle and aged females.

A fruit-taste yellow wine is prepared from fruit chosen from carambola, haw, jujube, litchi, apple, pear, etc. glutinous rice and rice leaven through choosing raw materials, culturing fruit-taste yeast, saccharifying, and fermenting twice. Its advantages are good color, taste and smell, and rice nutrients.

The invention relates to a microcapsule embedding preparation method of a Lactobacillus casei Zhang microcapsule Zhang CGMCC No.1697, comprising the following steps: activating Lactobacillus casei strain, preparing culture medium, preparing strain fermentation liquor, preparing microcapsule wall material, preparing microcapsule embedding solution and microcapsule.Compared with Lactobacillus casei which is not embedded, the Lactobacillus casei microcapsule prepared by the method of the invention, after being processed in artificial digestive juice, can have viable count increased by one magnitude order.After being preserved for 30 days at 37 DEG C, the Lactobacillus casei microcapsule can have viable count increased by more than one magnitude order.Therefore, the Lactobacillus casei microcapsule prepared by the method of the invention can greatly improve efficacy of probiotics in the process of processing, storage and transportation.

Disclosed is a nucleolin antisense oligonucleotide for inhibition of tumor cell proliferation. The nucleolin antisense oligonucleotide comprising 20 nucleotides is complementary to the nucleolin mRNA. When the nucleolin antisense oligonucleotide hybridizes to nucleolin mRNA, it is effective in suppression of nucleolin RNA synthesis and the corresponding protein expression, which subsequently arrests the growth rate of tumor cells. The nucleolin antisense oligonucleotide is effective in inhibition of nucleolin expression of tumor cells in vitro and in vivo. Therefore, the nucleolin antisense oligonucleotide can be used as a therapeutic agent for inhibition of tumor cell proliferation.

Disclosed is a antihypelipidemic and antihyperglycemic health food for preventing diseases including cardiovascular disease, diabetes, adjusting internal secretion, resisting osteoporosis and cancer, and beauty treatment. The raw materials include soybean powder 15-30 parts, pumpkin powder 15-30 parts, soybean isoflavones 0.5-1.5 parts, soybean saponin 2-5 parts, astragalus root 10-20 parts, wolfberry fruit 10-15 parts, kudzuvine root 10-15 parts, Chinese yam 10-15 parts, lotus plumule 6-10 parts, Siberian solomonseal rhizome 6-10 parts, cassia seed 6-10 parts, lily 5-8 parts, mulberry leaf 5-8 parts and ginseng 3-5 parts.

The invention discloses a substituted crotonamide maleate, a crystal form thereof, a method for preparing all crystal forms of crystallized maleate, relevant compounds, and a medicinal composition including the compounds. (E)-N-{4-[3-acetylenylphenylamino]-3-cyan-7-ethoxy-6-quinolyl}}-4(dimethylamino)-2-crotonamide maleate, a crystal form I, a crystal form II or a crystal form III respectively have EGFR or ErbB2 kinase inhibition activity, can be used to prevent, treat or inhibit tumors, and can be especially to prepare drugs for preventing, treating or inhibiting epidermal growth factor receptor family related tumors.

The invention relates to a stachyose probiotics solid beverage which changes nutritional properties of food and comprises the following components by weight percent: 5-20 percent of stachyose, 2-10 percent of bifidobacterium powder, 2-10 percent of lactobacillus acidophilus powder, 3-8 percent of whey protein powder, 5-15 percent of milk powder, 10-40 percent of grain puffing powder, 5-15 percent of steviol glycoside, 5-15 percent of maltodextrin, 5-15 percent of citric acid and 0.5-2 percent of edible essence, wherein the sum of weight percentage of all the components is 100%. The stachyose probiotics solid beverage adopts natural raw materials, is scientific in formulation, nutritionally balanced, unique in flavor, and sweet and sour, and palatable in taste, not only is beneficial to intestinal health, but also has the health functions of improving immunity of the organisms, delaying senescence, inhibiting tumor and regulating blood lipids, and is convenient to carry and brew.

The invention belongs to the field of microbial fungi, and relates to a selenium-rich cordyceps militaris strain CM001; the wild cordyceps militaris strain which is newly separated in the nature is selected as an original strain; the original strain is subjected to ultraviolet mutation, and the strain can be obtained by separating and screening; the selenium-rich cordyceps militaris strain is preserved in China General Microbiological Culture Collection Center (CGMCC) on July 18, 2014 with the preservation registration number of CGMCC No.9460, is named as CM001 and is named as cordyceps militaris in a classified way. Under the artificial culture conditions, the cordyceps militaris strain has the tolerance for high-concentration selenium, and can carry out biotransformation in a body; the hyphae yeast, the growth matrix or the sporocarp of the selenium-rich cordyceps militaris strain can be used as raw materials of medicines, foods and drinks, or can be prepared into powder, tablets, freeze-drying powder, capsules or electuary.

The invention belongs to the technical field of RNA interference, and discloses TGF-beta specific siRNA containing a free triphosphoric acid group and application thereof. The 5' ends of antisense strand and sense strand sequences of the TGF-beta specific siRNA containing the free triphosphoric acid group are guanosine, and the free triphosphoric acid group is modified on the pentose 3' site of the guanosine. By combining the TGF-beta specific gene silencing mechanism and the antiviral inherent immune mechanism of an induced eukaryotic cell, the siRNA can inhibit important molecule TGF-beta of mediated tumor immunologic escape, effectively activate the anti-tumor immunity of the body and remarkably improve the effect of treating tumor. The siRNA effectively solves the problem that the traditional siRNA (OH-RNA) only has single gene silencing function but poor tumor treatment effect. The ppp-TGF-beta can be applied to preparing a medicament for treating the tumor, in particular pancreatic cancer.

The invention discloses a preparation method of low-molecular-weight sea cucumber fucosan sulfate. In the preparation method, a sea cucumber polysaccharide prepared by performing enzymolysis on pulverized sea cucumbers is used as a raw material. The preparation method comprises the following steps: 1) dissolving the sea cucumber polysaccharide in a sodium chloride solution, then adding ethanol, and centrifuging to remove the precipitate, thus obtaining the supernatant; and adding ethanol into the supernatant, centrifuging, dialyzing the obtained precipitate, and performing freeze-drying to obtain sea cucumber fucosan sulfate; 2) dissolving the sea cucumber fucosan sulfate in solvent, and performing ultrasonic treatment at 0-45 DEG C, wherein the treatment time is 10-180 minutes, and the ultrasonic sound field strength is 60-800 W/cm<2>; and 3) dialyzing the treated solution obtained in the step 2), and performing vacuum freeze-drying to obtain the low-molecular-weight sea cucumber fucosan sulfate. According to the invention, an ultrasonic degradation technology is adopted, high-molecular-weight sea cucumber fucosan sulfate can be quickly degraded, the reaction conditions are mild, and the preparation method is green and environment-friendly.

The invention relates to a solid beverage suitable for obese patients. The special meal solid beverage suitable for obese patients is prepared in the following steps: mixing the dry powder of seabuckthorn, gingkgo, semen cassiae and green tea and the mixing powder of tuckahoe, Chinese yam, white hyacinth bean and rhizoma polygonati; screening to form the powder for producing and preparing the solid beverage of the obese patients. The solid beverage has the obvious effects of systemically adjusting lipid metabolism and glucose metabolism, losing weight, lowering blood fat, improving microcirculation and eliminating radicals. The special meal solid beverage is suitable for patients with adiposity, adiposis hepatica, hyperlipemia, high blood viscosity, hypertension and diabetes mellitus and middle-aged and old people to keep healthy and drink.

An efficient weight-lossing medicine or health-care food is prepared from carnitine (40-45 wt.%), chitosan (30-35), konjak (20-25) and flavouring (5-10).

The invention relates to a formula of Chinese herbal medicine herb tea, and particularly relates to health-preserving dendrobe herb teabeverage, and the invention also relates to a preparation method and an application of the health-preserving dendrobe herb tea. The health-preserving dendrobe herb tea beverage disclosed by the invention is prepared by elaborately blending eight Chinese herbal medicines, namely dendrobe, leaf of paniculate microcos, liquorice, chrysanthemum, honeysuckle, selfheal, lotus seed, and red dates. Compared with the traditional herb tea with a single function, the health-preserving dendrobe herb tea disclosed by the invention has the effects of dispelling wind and reducing pathogenic fire, clearing away the lung heat and moisturizing, enhancing physical fitness, tonifying deficiency and spleen, protecting liver and benefiting for gallbladder, strengthening tendons and reducing fat and blood sugar, and the like, can be applied to the fields such as the aspects of reducing blood sugar, restraining a tumor, delaying aging, and treating beauty and keeping the facial appearance, and is the herb tea beverage with the effect of preserving health in fact.

The invention discloses an anti-tumor diterpenoid compound isoeuphpekinensin which is separated from euphorbia roots, the chemical structure is as the right formula, the chemical structure and the spatial configuration of the compound are determined via the spectral analysis, the integrated analysis of nuclear magnetic resonance spectroscopy and the X-ray single crystal diffraction technology particularly. The preparation method is as follows: the fresh euphorbia root is cut into slices and dried, then ethanol is used for reflux extraction, the ethanol is recycled under reduced pressure, a liquid extract is obtained, and then the chromatographic separation is carried out on the liquid extract by a silica gel column, thereby obtaining the compound. In vitro anti-tumor experiments show that the compound has significant inhibition effect on human nasopharyngeal carcinomas cells, KB cells and others which are six types of tumor cell lines in total. The invention provides the lead compound for developing new anti-tumor medicaments, thereby having important significance on developing and utilizing medicinal plant resources of China.

The invention belongs to the technical field of chemical pharmacy, particularly relates to preparation of a derivative containing fluorine carboxylic acid ester and application of the derivative in tumor inhibition. The ester derivative is obtained by intriducing fluorocarboxylic acid in shikonin framework molecules through a synthetic method. An in-vitro antitumor activity study shows that the derivative containing the fluorocarboxylic acid has strong inhibition activity to tumor cell lines.