318results about How to "Improve metabolic activity" patented technology

The present invention relates to human metabolism, in particular fat reduction and a cosmetic and pharmaceutical formulation, as well as respective uses in particular together with a dressing material according to the invention.

The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a binding agent that can specifically bind to an epitope that comprises both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for the use of such therapeutic compositions in the treatment of cancer.

The invention also provides methods for therapeutically treating a mammal bearing a tumor comprising administering to the mammal an effective amount of a therapeutic composition consisting essentially of a binding agent that specifically binds to an epitope of tumor-associated MUC1, wherein the mammal generates an immune response that comprises an antibody that specifically binds to an epitope of tumor-associated MUC1 that is different from the epitope of tumor associated MUC1 that is specifically bound by the binding agent.

There are disclosed metabolically-engineered yeast and methods of producing n-butanol. In an embodiment, metabolically-engineered yeast is capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and expresses at least one enzyme for a metabolic pathway capable of utilizing NADH to convert acetyl-CoA to n-butanol. In another embodiment, a method of producing n-butanol includes (a) providing metabolically-engineered yeast capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and expresses at least one enzyme for a metabolic pathway utilizing NADH to convert acetyl-CoA to n-butanol; and (b) culturing the yeast to produce n-butanol. Other embodiments are also disclosed.

The invention discloses a mesenchymal stem cell self-preserving liquid which is prepared from the following raw materials according to volume ratios: 1-6% of self platelet lysate, 95-97% of solution medium and 0-1% of vitamin C injection, wherein the solution medium is a mixed sugar electrolyte injection or physiological saline injection. The mesenchymal stem cell self-preserving liquid has the advantages that: growth factors contained in the mesenchymal stem cell self-preserving liquid can maintain the activity state of cells, the vitamin C can maintain the activity of various peroxidases, at the same time, the mixed sugar electrolyte injection is especially suitable for cell preservation, and osmotic pressure is also favorable for nutrient absorption of the cells so as to carry out metabolism; the activity of the mesenchymal stem cells which are preserved in the mesenchymal stem cell self-preserving liquid within 8 hours is still larger than 90%, the cell activity change is not larger than 7%, and the activity of the mesenchymal stem cells which are preserved in the mesenchymal stem cell self-preserving liquid within 12 hours is still maintained at 85%; and by using the mesenchymal stem cell self-preserving liquid, the requirements for human intravenous back-transfusion safety can be met, and the cell preserving problem of long-time transport is solved, thus more patients have opportunity to undergo mesenchymal stem cell treatment.

The embodiments herein disclose a method of fabricating composite scaffolds for skin tissue regeneration. The methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA) are synthesized. The poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds are synthesized. The hydrogel is synthesized. The composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds is fabricated. A plurality of physico-chemical characteristics of the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds are analysed. The physico-chemical characteristics comprises mechanical properties, swelling ratio and enzymatic degradation and scanning electron microscope imaging. The fibroblast cells are encapsulated within the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds and hydrogels. The fibroblast cells are seeded on composite scaffold and PGS-PCL scaffold. The fibroblast cell viability, fibroblast cell attachment, fibroblast cell spreading, fibroblast cell proliferation and fibroblast cell metabolism are analysed in composite scaffolds, PGS-PCL scaffolds and hydrogels.

The present invention provides a method of producing a plant which exhibits improved growth and/or yield under reduced nitrogen conditions, that is, under cultivation conditions where nitrogen is limited as compared to ordinary cultivation conditions, by increasing 2-OG content in plants. Particularly, the present invention provides a method of producing a plant which exhibits improved growth and/or yield under conditions where nitrogen is reduced, that is, under cultivation conditions where nitrogen is limited as compared to ordinary cultivation conditions, by introducing a GDH gene or ECASPC gene into plants and expressing the transgene GDH or ECAPS in the plants, which results in increased 2-OG, or by spraying proline on the leaves of plants to increase the 2-OG content, thereby enhancing the incorporation of nitrogen or metabolic activity of plants. Also provided is a method of cultivating such plants under nitrogen-limited conditions.

Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.

The invention relates to a system and a method for culturing aerobic grain sludge(AGS) and treating organic waste water generated during the culture of the aerobic grain sludge. An SBR system with short period is adopted to culture the aerobic grain sludge(AGS) and treat the organic waste water. The system consists of a main reactor, a water charging system, a water discharging system, an aeration system and a corresponding self-control device. A 2.5h short-period SBR operating mode is adopted, and four stages of water charging, aeration, precipitation and water discharging are included in each period. The water charging time is 5 min, the aeration is started while charging water, the aeration time is 132 to 144 min, the precipitation time is 3 to 15 min, and the water discharging time is 3 min. The pH value of the culture and treatment system is controlled by adding bicarbonate. The bicarbonate is sodium bicarbonate, and the adding range is between 0 and 1,200 mg/L. By utilizing the system and the method, the AGS can be quickly and economically cultured, and the organic substances, nitrogen and phosphorus in the organic waste water can be treated in high efficiency. The system and the method can be applied to the culture and production of the aerobic grain sludge and the treatment of the organic waste water, so that the system and the method have important practical values.

The invention relates to nano-liposome emulsion. A seaweed extract is packaged inside a nano-liposome. The nano-liposome emulsion contains 10wt%-20wt% of the seaweed extract, 10wt%-20wt% of lecithin, 1wt%-3wt% of a propping agent, 0.01wt%-0.1wt% of an antioxidant, 10wt%-20wt% of a solubilizer and 10wt%-20wt% of a stabilizing agent. According to the invention, the nano-liposome emulsion inside which the seaweed extract is packaged is prepared at first and has a skin regeneration function, and a product has relatively good water solubility and can be randomly mixed with a skin care preparation, so that a functional cosmetic is relatively convenient and efficient in preparation. A liposome packaging process can be used for improving the stability of the seaweed extract and the compatibility of the seaweed extract in a cosmetic system; the carrying function of the liposome is beneficial for the seaweed extract to go deep into a deep layer of the skin, thus a sensitization response caused by direct contact between the seaweed extract and the epidermic cells of the skin is reduced or avoided, and the seaweed extract is also fully takes the effects.

The invention discloses a compound traditional Chinese medicinal composition for cows, and a preparation method and an application thereof, and belongs to the technical filed of traditional Chinese medicines for animals. The compound traditional Chinese medicinal composition mainly comprises, by weight, 10-20 parts of Chinese angelica, 10-20 parts of Ligusticum wallichii, 15-20 parts of Ricepaperplant Pith, 10-20 parts of Vaccaria segetalis, 5-10 parts of Radix Astragali, 5-10 parts of Spina Gleditsiae, 5-10 parts of Radix Codonopsis, 1-5 parts of Radix Rhapontici, 1-5 parts of Fructus Liquidambaris, 5-10 parts of licorice root, 10-20 parts of Rhizoma Atractylodis Macrocephalae and 5-10 parts of Herba Leonuri. The composition adopting the above 12 pure natural Chinese herbal medicines has the characteristic of no medicine resistance, small toxic side effects, difficult generation of harmful residues in milk products, and can effectively improve the milk yield of the cows, substantially improve the quality of the cows and the healthy level of the cows and prevent the mastitis of the cows; and compared with fructo-oligosaccharide compatibility compositions, the compound traditional Chinese medicinal composition disclosed in the invention has the advantages of improvement of the immunity of bodies, improvement of the gastrointestinal tract environment of the bodies, adjustment of the gastrointestinal flora balance, and promotion of the digestion and absorption of nutritional substances.

Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells.

The invention discloses a method for producing methane in anaerobic digestion by pretreating sludge through steam explosion. The method comprises the following steps of: (1) steam explosion pretreatment: to be specific, adding dehydrated sludge with 55%-85% of moisture content to 0.5-1% SDS (Sodium Dodecyl Sulfate) according to mass ratio, then putting into a gas explosion machine, feeding saturated steam with moisture content of 1%-2%, maintaining needed temperature and pressure for 2-10min, and opening an emptying valve of the gas explosion machine for collecting materials; and (2) inoculated fermentation: to be specific, adding inoculums to the preprocessed material, wherein the inoculum quantiy accounts for 3%-50% of the mass of the material, sealing and fermenting after uniformly stirring. The method has the advantages of being capable of improving the biodegradability of sludge, being beneficial to degradation of microorganisms and increasing the utilization rate and gas output of sludge.

The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.

The invention discloses a magnetite-zeolite magnetic biological carrier material, as well as a preparation method and an application method thereof. The magnetite-zeolite magnetic biological carrier material adopts raw materials such as zeolite, magnetite and cement. The preparation method comprises the following steps of: smashing and sieving the zeolite and magnetic iron ores, then adding the cement, mixing to be uniform and then adding water, pelleting, moulding and standing for more than 10 days at normal temperature, and continuously spraying water onto the surfaces of the obtained particles during standing so as to keep the surfaces of the particles to be wet, thus the finished product is obtained. The magnetic biological carrier disclosed by the invention can be applied to deep treatment of domestic sewage secondary treatment water, deep treatment and resource utilization of industrial waste water, deep treatment of micro-pollution drinking water and urban landscape water treatment.

The invention discloses a treatment method of high iron manganese and ammonia nitrogen compound pollution low temperature underground water. Natural zeolite is used as a raw material, a zeolite-basedmaterial is loaded with manganite, through impregnation of enrichment culture liquid, the material is loaded with microorganisms of nitrifying bacteria, iron and manganese oxidizing bacteria and the like, so that a multifunctional compound material of the zeolite loaded with the manganite and the microorganisms is obtained, a filter candle is filled with the multifunctional compound material, sequencing batch running is conducted according to four stages of inlet water adsorption, water emptying, air blasting for bio-regeneration and nitrate washing, meanwhile, iron, manganese and ammonia nitrogen in the low temperature underground water are purified, and thus effluent reaches the domestic drinking water quality standards.

The invention discloses a method for harmless treatment of ferment antibiotic fungus residues. The method includes: subjecting the ferment antibiotic fungus residues to ultrahigh-temperature intensive acidogenic fermentation treatment; performing biochemical treatment on the fungus residues subjected to ultrahigh-temperature intensive acidogenic fermentation treatment. Thermophilic hydrolysis acidogenic bacteria are adopted for high-temperature anaerobic acidogenic fermentation treatment of the ferment antibiotic fungus residues, the fungus residues are hydrolyzed and acidized, antibiotic producing strains in the fungus residues are inactivated, residual antibiotics are degraded prior to biochemical treatment, and accordingly harmless treatment and recycling of the antibiotic fungus residues are realized. By adoption of the method, the antibiotic producing strains in the fungus residues subjected to harmless treatment are completely killed, antibiotic residues are avoided, and the fungus residues subjected to biochemical treatment is free of dangers caused by drug-resistant fungi and drug-resistant genes. The method has advantages that efficiency in harmless treatment of the antibiotic fungus residues is improved, environment protection is benefited, hazardous wastes are recycled, and remarkable economic benefits and social benefits are achieved.

The present invention relates to the use of 3-dimensional (3D) synthetic or animal-derived bioscaffolds as substrates for the improved growth and differentiation of hPS (Human pluripotent stem cells); these scaffolds being adapted for use in conjunction with existing cell culture lab plastic-ware. More specifically, it relates to the seeding of these scaffolds, either alone or in conjunction with various biologic matrix coatings, with hPS cells for the improved differentiation of said hPS cells into hepatocyte or hepatocyte-like cell types. The invention also relates to the seeding of partially-differentiated hepatocyte progenitors onto scaffolds for further differentiation into more mature hepatocyte-cell types.

The invention discloses electric-heating far-infrared health-protection material, a preparation method and application thereof; the preparation method comprises the following steps: adding white carbon black, nano active calcium silicate, nano precipitated barium sulphate, and nano tourmaline powder to conductive carbon ink according to proportions; stirring and blending manually to obtain a mixture, mixing the mixture in an oil-ink stirring machine for 30 minutes, then grinding the mixture on a three-roller grinding machine for two times; finally, storing the mixture at 20-25 degrees centigrade not less than 24 hours so as to prepare a heating coat layer. According to the invention, the heating coat layer is coated on flexible or rigid base body material in a screen printing method and is placed in an electric-heating constant temperature drying oven; the heating coat layer is dried and cured on conditions of 80 degrees centigrade and 20 minutes plus 120 degrees centigrade and 30 minutes plus 150 degrees centigrade and 30 minutes; electrodes are manufactured and packaged; and nano negative ion cloth or nano tourmaline cloth is coated on the surface of the heating coat layer so as to prepare the electric-heating far-infrared health-protection material. The electric-heating far-infrared health-protection material can be widely used for fields of industry, agriculture, civil, medical treatment and the like.

A deep restoration mask is made through dipping a liquid in mask paper, and 1000 parts of the liquid are prepared from, by weight, 0.1-3 parts of micro-molecular hyaluronic acid, 0.1-2.5 parts of macromolecular hyaluronic acid, 0.7-30 parts of synthetic egg white powder, 1-7 parts of an aloe extract product, 0.7-9 parts of propylene glycol, 5-50 parts of 1,2-butylene glycol, 5-30 parts of glycerin, 20-80 parts of a licorice root extract liquid, 20-80 parts of a gherkin extract liquid, 20-80 parts of a Fructus Arctii extract liquid, 20-80 parts of a ginkgo extract liquid, 2-10 parts of water-soluble alpha-bisabolol, 10-50 parts of water-soluble mint oil, 5-20 parts of rose hydrolat, 0.1-1 part of apple stem cells, 0.5-5 parts of silk peptides, 0.1-1 part of tetrahydropiperine, 5-20 parts of water-soluble vitamin E nicotinate, and the balance of water. Effective components of the mask can be fast absorbed, can accelerate restoration of damaged skins, cause no irritation or allergy, and are suitable for all skin types.

The invention relates to an oat and linolenic acid composite beverage, relates to a preparation method of the beverage, and belongs to the technical field of processing of other beverages. The oat and linolenic acid composite beverage is mainly prepared from the following raw materials in percentage by mass: 1-6% of oat, 1-8% of linseed oil, 2-3% of maltose, 0.2-0.6% of fructo-oligosaccharide, 1-3% of xylitol, 1-4% of cane sugar or starch syrup, 2-6% of coconut milk, 0.1-0.3% of a composite emulsion stabilizer, 0.005-0.01% of edible essence and 0.1-1% of sodium ascorbate. According to the oat and linolenic acid composite beverage disclosed by the invention, the oat is used as a main raw material, the linseed oil and the coconut milk are added, the specific composite emulsion stabilizer is matched, and a specific technology is used, so that the oat and linolenic acid composite beverage is prepared. High omega-3 fatty acid content of the oat beverage is guaranteed, and besides, a good stabilizing effect can be achieved. Under normal temperature, after being subjected to standing for 3 months, the oat and linolenic acid composite beverage does not generate precipitates, and is free of a layering phenomenon and the phenomenon that fat floats upwards.

The invention relates to the field of microbial fermentation and provides a towel gourd enzyme solution with whitening and moisturizing functions and a mask product thereof. The method comprises the following steps: adopting an enzyme stock solution rich in viable organisms and fresh towel gourd fruit and performing secondary fermentation; fully releasing the nutrition and functional components from the towel gourd under the effect of microorganisms; and lastly, using the fermented stock solution as the towel gourd enzyme mask product for whitening and moisturizing. The product provided by the invention has the characteristics of safety, health and obvious effect.

The invention provides recombinant forms of piscine follicle-stimulating hormone (FSH) with characteristic intramolecular disulfide bonds and modified glycosylation patterns in the β-subunit that enhance the stability and metabolic activity of the hormone. Also provided are recombinant materials to produce the FSH β and glycoprotein α-subunits singly or in combination to obtain complete heterodimeric hormone of regulated glycosylation pattern. The piscine FSH agonists of the invention are therapeutically useful to expedite the onset of puberty in captive fish and to alleviate reproductive dysfunctions in fish. Likewise, the piscine FSH antagonists of the invention will be therapeutically useful to halt gonadal development, thereby contributing to body weight gain of the fish,