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Method for harmless treatment of ferment antibiotic fungus residues

A technology of antibiotic residues and antibiotics, applied in the field of harmless treatment of antibiotic residues, can solve the problems of difficult release of intracellular organic matter, difficulty in fully utilizing, low efficiency of methane production steps, etc.

Active Publication Date: 2017-03-08
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the anaerobic digestion of microbial cell aggregates such as bacterial residues, the hydrolysis acid production step is the rate-limiting step of anaerobic methanation, resulting in very low efficiency of the hydrogen production, acetogenic steps and methane production steps
However, due to the rigid cell wall of the mycelium in the antibiotic residue, the release of intracellular organic matter is difficult and difficult to be fully utilized. Therefore, it is necessary to take physical or chemical means to break the wall to improve the release rate of intracellular dissolved organic matter, effectively Improve the utilization rate of organic matter and biogas production rate of fungal residue

Method used

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  • Method for harmless treatment of ferment antibiotic fungus residues
  • Method for harmless treatment of ferment antibiotic fungus residues
  • Method for harmless treatment of ferment antibiotic fungus residues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] The harmless treatment of embodiment 1 oxytetracycline bacterium slag

[0097] 1. Preparation of strains and sludge

[0098] 1-1) Preparation of thermophilic acid-producing bacteria

[0099] The thermophilic strains in Table 2 were inoculated on LB agar culture (tryptone 10g / L, yeast extract 5g / L, sodium chloride 10g / L, agar 15-20g / L, pH7), respectively, at 55°C Under anaerobic culture; then select the colonies with good growth status (big colonies) and inoculate them in fresh LB liquid medium (tryptone 10g / L, yeast extract 5g / L, sodium chloride 10g / L, pH7 ), anaerobic enrichment culture at 55°C until the biomass of the strains in the liquid medium increased to (1-2)×10 8 Bacteria / ml; then the culture solution of 7 strains of thermophilic bacteria was mixed in proportion to obtain thermolytic acid-producing bacteria, which were inoculated in the reactor to start the ultra-high temperature anaerobic fermentation treatment, among which 7 strains of thermophilic bacteria...

Embodiment 2

[0145] The harmless treatment of embodiment 2 penicillin scum

[0146] 1. Preparation of strains and sludge

[0147] 1-1) Preparation of thermophilic acid-producing bacteria

[0148] Except that the inoculation ratio of the 7 strains of thermolytic acid-producing bacteria is 0.8:1:1.2:1:1.2:0.8:1, the rest are the same as step 1-1) in Example 1.

[0149] In the present invention, Sarcina, Clostridium, Anaerobaculum, Coprothermobacter, Fervidobacterium, Caloranerobacter, the proportioning of Thermus in the thermophilic acid-producing bacteria except 0.8:1:1.2:1:1.2:0.8:1, the dosage proportioning is (0.8 -1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2) are applicable to the present invention.

[0150] 1-2) Preparation of medium temperature digested sludge and municipal surplus sludge

[0151] Medium temperature digested sludge, municipal residual sludge are the same as in step 1-2) in embodiment 1;

[0152] 2. Start-up treatment of ultra-high temperature anae...

Embodiment 3

[0172] The harmless treatment of embodiment 3 cephalosporin slag

[0173] 1. Preparation of strains and sludge

[0174] 1-1) Preparation of thermophilic acid-producing bacteria

[0175] Except that the inoculation ratio of the 7 strains of thermolytic acid-producing bacteria is 1:1.2:1:0.8:0.8:1:1.2, the rest are the same as step 1-1) in Example 1.

[0176] In the present invention, arcina, Clostridium, Anaerobaculum, Coprothermobacter, Fervidobacterium, Caloranerobacter, the proportioning of Thermus except 1:1.2:1:0.8:0.8:1:1.2 in the thermophilic acid-producing bacteria, the dosage proportioning is (0.8 -1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2) are applicable to the present invention.

[0177] 1-2) Preparation of medium temperature digested sludge and municipal surplus sludge

[0178] Medium temperature digested sludge, municipal residual sludge are the same as in step 1-2) in embodiment 1;

[0179] 2. Start-up treatment of ultra-high temperature ...

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Abstract

The invention discloses a method for harmless treatment of ferment antibiotic fungus residues. The method includes: subjecting the ferment antibiotic fungus residues to ultrahigh-temperature intensive acidogenic fermentation treatment; performing biochemical treatment on the fungus residues subjected to ultrahigh-temperature intensive acidogenic fermentation treatment. Thermophilic hydrolysis acidogenic bacteria are adopted for high-temperature anaerobic acidogenic fermentation treatment of the ferment antibiotic fungus residues, the fungus residues are hydrolyzed and acidized, antibiotic producing strains in the fungus residues are inactivated, residual antibiotics are degraded prior to biochemical treatment, and accordingly harmless treatment and recycling of the antibiotic fungus residues are realized. By adoption of the method, the antibiotic producing strains in the fungus residues subjected to harmless treatment are completely killed, antibiotic residues are avoided, and the fungus residues subjected to biochemical treatment is free of dangers caused by drug-resistant fungi and drug-resistant genes. The method has advantages that efficiency in harmless treatment of the antibiotic fungus residues is improved, environment protection is benefited, hazardous wastes are recycled, and remarkable economic benefits and social benefits are achieved.

Description

technical field [0001] The invention relates to a method for harmless treatment of waste in the pharmaceutical industry, in particular to a method for harmless treatment of antibiotic residue produced by fermentation, and belongs to the field of solid waste treatment. Background technique [0002] Antibiotic residues are solid wastes produced during the production of antibiotics, and their main components are mycelium aggregates of antibiotic-producing bacteria, residual culture medium, metabolites produced during fermentation, degradation products of the culture medium, and a small amount of antibiotics. Wait. Due to the residual medium and a small amount of antibiotics and their degradation products in antibiotic residues, there is potential harm to the ecological environment, and has been regarded as one of the main public hazards of antibiotic production by the international community. Antibiotic residues contain a certain amount of antibiotic residues and are listed as...

Claims

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Application Information

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IPC IPC(8): C12P5/02C12R1/01C12R1/145
CPCC12P5/023Y02E50/30
Inventor 田哲张昱杨敏高迎新丁然
Owner RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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