6 results about "Antibiotic production" patented technology

This invention belongs to the field of pharmaceutical wastewater treatment technology, and particularly relates to an ultrasonic-coupled electrochemical pretreatment device and method for high-concentration antibiotic production wastewater. The device consists of an ultrasonic treatment first reactor, an electrochemical second reactor, and a flocculation sedimentation third reactor connected in series via pipelines. The first reactor is equipped with a wall-mounted ultrasonic transducer; the second reactor contains a stabilizing electrode and a sacrificial electrode, and multiple disc aerators are installed at the bottom; the third reactor contains an overflow trough, inclined tube packing, and an electromagnet. This invention can achieve efficient desorption and mineralization degradation of adsorbed antibiotics in suspended solids in production wastewater, reduce antibiotic and degradation product residues in flocs, and eliminate toxic effects on subsequent biological treatment processes.

The utility model discloses a high-salt antibiotic wastewater treatment device which comprises a DT membrane filtering assembly, a forced crystallization assembly and a crystallized salt separating and drying assembly which are sequentially communicated, the DT membrane filtering assembly is used for filtering and separating wastewater, and the forced crystallization assembly is used for concentrating and crystallizing wastewater. The crystallized salt separating and drying assembly is used for separating and drying crystallized salt, and a salt outlet pipeline of the crystallized salt separating and drying assembly is communicated with the crystallized salt temporary storage device. According to the high-salt antibiotic wastewater treatment device disclosed by the utility model, a process of synergistically combining the DT membrane filtering component, the forced crystallization component and the crystallized salt separating and drying component is adopted, so that sodium chloride in antibiotic wastewater can be continuously, efficiently and quickly separated and purified; the method has the advantages of simple operation process, strong operability and controllability, high recovery rate, and capability of obtaining sodium chloride meeting the standard of being reused for an antibiotic production line, meets the requirements of production and reuse, is energy-saving and environment-friendly, and reduces the operation cost.

The application provides an antibiotic generation method based on antibacterial activity guided search optimization, and the implementation steps are as follows: (1) obtaining an antibiotic molecule data set; (2) constructing a training sample set and a test sample set; (3) constructing an antibacterial activity prediction network model C; (4) iteratively training the antibacterial activity prediction network model C; (5) constructing an antibiotic generation network model H; (6) iteratively training the antibiotic generation network model H; (7) optimizing the antibiotic molecule through antibacterial activity guided search; and (8) generating an optimization result; the application solves the technical problems of low generation efficiency and inability to guarantee that the generated compound molecules after optimization all have expected activity in the prior art, effectively improves the generation efficiency, and guarantees that the generated antibiotic molecules all have expected antibacterial activity, and can be used for guiding the research and development of new drugs.

The invention relates to a recycling treatment method of cephalosporin antibiotic production wastewater. The method comprises a wastewater flocculation treatment step, a hollow fiber membrane ultrafiltration treatment step, a step of carrying out concentration treatment on ultrafiltration produced water by adopting a reverse osmosis membrane, a step of carrying out salt separation treatment on reverse osmosis concentrated water by adopting a nanofiltration membrane, and a step of carrying out concentration treatment on nanofiltration produced water by adopting a reverse osmosis membrane. According to the method, water and salt (monovalent salt and divalent salt) are effectively recycled from the cephalosporin antibiotic production wastewater, the recycled water can be used as water for circulating cooling water, and the water quality of the water meets related requirements of the water for circulating cooling water of enterprises, so that the emission of pollutants is reduced, and even zero emission of sewage is realized; and the method has remarkable social benefits and economic benefits.

The invention relates to a method of modulating production of a metabolite in an actinomycetes bacterium comprising increasing the expression or activity of the Sporulation and Antibiotic Production Related gene A (SarA. SCO4069) polypeptide to modulate production of the metabolite in the actinomycetes bacterium. In one embodiment, the metabolite is valinomycin, daidzein, fluvirucin, demethyllydicamycin, or TPU-0037 analogues A. C and D.

The application relates to the technical field of functional egg production management, and discloses a blockchain traceability method and system for non-antibiotic production of functional eggs, which records multi-source traceability data of functional eggs from breeding to the whole chain of sales, generates a hash value and a digital identity identifier by using the multi-source traceability data, associates the digital identity identifier with the multi-source traceability data, binds the hash value with the digital identity identifier by using a blockchain, generates a two-dimensional code picture through the digital identity identifier, and traces the source by scanning the two-dimensional code. The multi-source traceability data of functional eggs from breeding to the whole chain of sales is recorded and collected, information is more comprehensive, the hash value and the digital identity identifier are generated by using the multi-source traceability data and are associated, the data can be prevented from being modified by setting the hash value, the data authenticity is improved, the data can be better mastered, and all the information is recorded by using the regional chain, so that information islands are avoided.