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Process for recovering sodium isooctoate from pharmaceutical waste liquor

A technology of sodium isooctanoate and isooctanoic acid, which is applied in the direction of carboxylate preparation, carboxylate preparation, carboxylate preparation, etc., can solve the problems of environmental pollution, production cost increase, consumption of sodium isooctanoate, etc., and achieve simple operation, Low cost, cost and time saving effect

Inactive Publication Date: 2015-06-03
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the waste liquid recovery process of antibiotic production in domestic pharmaceutical factories generally only includes the recovery of organic solvents (solvents), and isooctanoic acid and isooctanoate are discharged directly with the remaining waste liquid. This treatment method not only pollutes the environment, but also causes The large consumption of sodium isooctanoate increases the production cost

Method used

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  • Process for recovering sodium isooctoate from pharmaceutical waste liquor
  • Process for recovering sodium isooctoate from pharmaceutical waste liquor
  • Process for recovering sodium isooctoate from pharmaceutical waste liquor

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Take 200g of pharmaceutical waste liquid and place it in a 500ml three-necked flask, distill off the water and residual organic solvent in the waste liquid at 100°C to obtain 62.8g of semi-solid waste, put the semi-solid waste in a 500ml beaker, and add 10ml of concentration dropwise It is a 95% concentrated sulfuric acid solution, stirred for 10 minutes, after the isooctanoic acid salt and sulfuric acid are fully reacted, add 200ml of distilled water, stir for 10 minutes, after standing for stratification, take the upper oil phase, shake and wash twice with 200ml of distilled water, and obtain the crude product of isooctanoic acid 40.0ml, put it in a three-necked flask, distill under reduced pressure, the distillation pressure is 20kPa, and the distillate at a temperature of 170-180°C is collected to obtain 22.3g of isooctanoic acid product, and the purity of isooctanoic acid is detected by gas chromatography; Isooctanoic acid essence reacts with sodium carbonate to gen...

Embodiment 2

[0036] Get 200g pharmaceutical waste liquid and place in the 500ml there-necked flask, distill off water and residual organic solvent in the waste liquid, obtain 60g semi-solid waste material, waste material is placed in the 500ml beaker, dropwise the formic acid solution that 20ml concentration is 88%, Stir for 10 minutes, add 200ml of distilled water after fully reacting isooctanoic acid with formic acid, stir for 10 minutes, after standing for stratification, take the upper oil phase, wash twice with 200ml of distilled water to obtain 41.8ml of crude isooctanoic acid, put it in a 100ml three-port In the flask, distill under reduced pressure, the distillation pressure is 20kPa, and the distillate collected at a temperature of 170 to 180° C. is obtained to obtain 23.4 g of isooctanoic acid refined product, and the purity of isooctanoic acid is detected by gas chromatography; Sodium octanoate, calculate the yield.

[0037] The method for detecting the purity of isooctanoic aci...

Embodiment 3

[0040] Get 200g of pharmaceutical waste liquid and place it in a 500ml three-necked flask, distill off the water and residual organic solvent contained in the waste liquid to obtain 65.1g of semi-solid waste, place the waste in a 500ml beaker, and add 25ml of 38% hydrochloric acid dropwise solution, stirred for 10 minutes, after fully reacting isooctanoate with hydrochloric acid, add 100ml of distilled water and 100ml of ether, stir for 10min, after standing for stratification, take the upper oil phase and shake and wash twice with 200ml of distilled water to obtain 140ml of crude isooctanoic acid. Put the caprylic acid crude product in a three-necked flask, distill under reduced pressure, the distillation pressure is 20kPa, and collect the distillate at a temperature of 170-180°C to obtain 23.0g of iso-octanoic acid fine product. The purity of iso-octanoic acid is detected by gas chromatography; Sodium carbonate reacts to generate sodium isooctanoate, and the yield is calculat...

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Abstract

The invention discloses a process for recovering isooctanoic acid from pharmaceutical waste liquor and transforming isooctanoic acid into sodium isooctoate. The process comprises the following steps of: removing water and residual organic solvents which are contained in the waste liquor through preliminary distillation, then adding acid for acidification to transform isooctoate contained in a waste material into isooctanoic acid, adding an extracting agent to split the phase of the acidified waste material, and repeatedly washing an oil phase rich in the isooctanoic acid by using distilled water to obtain a crude isooctanoic acid product; then carrying out reduced pressure distillation to obtain a finished isooctanoic acid product; finally reacting the obtained finished isooctanoic acid product with sodium alkali to generate sodium isooctoate. The process disclosed by the invention can be used for effectively recovering isooctanoic acid contained in antibiotic production waste liquor, namely ampicillin sodium, amoxicillin sodium, cephalosporin sodium salt and the like which are obtained through a solvent crystallization method, and transforming isooctanoic acid into salt-forming agent sodium isooctoate capable of being recycled.

Description

technical field [0001] The present invention relates to a recovery and treatment process of pharmaceutical waste liquid, in particular to a process for recovering isooctanoic acid from pharmaceutical waste liquid containing isooctanoic acid and isooctanoate and transforming it into recyclable salt-forming agent sodium isooctanoate process method. Background technique [0002] In the pharmaceutical industry, the solvent crystallization method is one of the commonly used methods for the production of antibiotics such as ampicillin sodium, amoxicillin sodium and cephalosporin sodium salts. In the production process of this method (taking the production of ampicillin sodium as an example), the Ampicillin acid is dissolved in an organic solvent containing an organic base, and then an organic salt-forming agent containing sodium ions is added to cause a metathesis reaction to generate crystals of ampicillin sodium, and finally ampicillin sodium is obtained through processes such a...

Claims

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Application Information

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IPC IPC(8): C07C53/126C07C51/41
CPCC07C51/412C07C51/02C07C53/128
Inventor 王志英刘启东吴南星李春利
Owner HEBEI UNIV OF TECH
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