The present invention discloses a children
ampicillin sodium compound entity, wherein the preparation method comprises: (1) adding
ampicillin to a
mixed solution of
dichloromethane and
triethylamine, cooling, adding a small amount of a
sodium 2-ethylhexanoate solution, increasing the solution temperature, adding the remaining
sodium 2-ethylhexanoate solution, carrying out suction
filtration, washing, and carrying out
vacuum drying to obtain an
ampicillin sodium crude product; (2) dissolving the
ampicillin sodium crude product in
purified water, adding
active carbon, carrying out stirring decolorizing, and filtering; (3) adding an extractant to the filtrate under the stirring, transferring and filling into a
pressure resistance container, removing air bubbles, carrying out sealing oscillation, carrying out
temperature control freezing, and taking out; and (4) carrying out liquid-
solid separation, discarding the extractant, adding
acetone in a dropwise manner at a temperature of 5 DEG C after the
solid melts, stirring at a
slow speed, growing the grain, filtering, washing, and carrying out
vacuum drying to obtain the
ampicillin sodium finished product. The children
ampicillin sodium compound entity of the present invention has advantages of good
solubility, good
clarity, low related
substance content, good stability, low toxic-
side effect, and the like.