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The sodium salt form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin sodium inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall.
A process for the preparation of low moisture ampicillin acid
The application discloses a preparation method of low-moisture ampicillin acid, and belongs to the field of ampicillin acid, and comprises the following steps: step one, stirring and heating after mixing ampicillin trihydrate and isopropyl alcohol in a reaction kettle; step two, starting vacuumizing after heating; step three, carrying out reflux operation after vacuumizing; step four, after refluxing for a certain period of time, leading out distillate, and synchronously supplementing isopropyl alcohol; step five, stopping distillation after leading out distillate, cooling and breaking vacuum; and step six, filtering out solid after cooling, washing, drying and obtaining low-moisture ampicillin acid. The water and isopropyl alcohol of ampicillin trihydrate are slowly distilled out of the system by azeotropic distillation, so that low-moisture ampicillin acid is obtained. The low-moisture ampicillin acid can slow down the degradation of ampicillin by water, effectively reduce the impurity content, and improve the yield of ampicillin sodium produced by ampicillin acid.
Owner:SHANXI XINBAOYUAN PHARMA CO LTD