5 results about "Ampicillin Sodium" patented technology

The invention belongs to the field of medicine product crystallization, and discloses a novel ampicillin sodium crystal form and a preparation method thereof. In an X-ray diffraction pattern of the novel crystal form of ampicillin sodium, characteristic peaks exist at 2theta diffraction angles of 6.1 + / -0.2 degrees, 9.4 + / -0.2 degrees, 11.9 + / -0.2 degrees, 12.2 + / -0.2 degrees, 12.7 + / -0.2 degrees, 15.1 + / -0.2 degrees, 16.1 + / -0.2 degrees, 17.6 + / -0.2 degrees, 18.3 + / -0.2 degrees, 18.8 + / -0.2 degrees, 19.7 + / -0.2 degrees, 19.9 + / -0.2 degrees, 21.3 + / -0.2 degrees, 21.5 + / -0.2 degrees, 23.4 + / -0.2 degrees, 24.0 + / -0.2 degrees, 25.2 + / -0.2 degrees, 26.1 + / -0.2 degrees, 27.9 + / -0.2 degrees and 30.2 + / -0.2 degrees. The preparation process of the novel ampicillin sodium crystal form provided by the invention is simple to operate, low in energy consumption, high in economical efficiency and good in reproducibility. The obtained ampicillin sodium new crystal form product is high in crystallinity, good in stability, excellent in morphology, large and uniform in particle size (larger than or equal to 230 microns) and high in content (larger than or equal to 88.0% in terms of C16H19N3O4S, and the sodium content is 5.9%-6.5%).

The application discloses a preparation method of low-moisture ampicillin acid, and belongs to the field of ampicillin acid, and comprises the following steps: step one, stirring and heating after mixing ampicillin trihydrate and isopropyl alcohol in a reaction kettle; step two, starting vacuumizing after heating; step three, carrying out reflux operation after vacuumizing; step four, after refluxing for a certain period of time, leading out distillate, and synchronously supplementing isopropyl alcohol; step five, stopping distillation after leading out distillate, cooling and breaking vacuum; and step six, filtering out solid after cooling, washing, drying and obtaining low-moisture ampicillin acid. The water and isopropyl alcohol of ampicillin trihydrate are slowly distilled out of the system by azeotropic distillation, so that low-moisture ampicillin acid is obtained. The low-moisture ampicillin acid can slow down the degradation of ampicillin by water, effectively reduce the impurity content, and improve the yield of ampicillin sodium produced by ampicillin acid.

The invention discloses a comprehensive recovery method of ampicillin sodium crystallization mother liquor, which comprises the following steps: enabling the ampicillin sodium crystallization mother liquor to pass through oxyhydrogen anion exchange resin, adsorbing ampicillin acid radical ions and isooctanoic acid radical ions on the resin through ion exchange, the ampicillin hydrochloride and the isocaprylic acid desorption solution obtained through desorption are separated through macroporous adsorption resin, and then the ampicillin and the isocaprylic acid salt are obtained through the processes of desorption, crystallization and drying. According to the method, the oxyhydrogen anion exchange resin and the macroporous adsorption resin are combined to separate and recover the active ingredients ampicillin and isocaprylic acid in the mother liquor, and the ion exchange and adsorption process is mild in condition, can be carried out at normal temperature, and has high recovery purity and recovery rate; and the cost and difficulty of the subsequent refining process are reduced.

The invention belongs to the technical field of pharmacy, and relates to a preparation method of ampicillin sodium. The preparation method comprises the following steps: mixing ampicillin acid and sodium type cation exchange resin in water according to a certain proportion, stirring and dissolving, filtering to obtain an ampicillin sodium solution, and concentrating and freeze-drying to obtain the ampicillin sodium with the quality meeting the standard. According to the preparation method, the raw material ampicillin acid does not need to be dehydrated, any organic solvent does not need to be used, the ampicillin acid can be directly converted into the ampicillin sodium only through the cation exchange resin, the process design is innovative, the operation is simple and convenient, the energy consumption is low, and the obtained ampicillin sodium product is high in quality and stable.

The invention provides a human mycoplasma pneumoniae culture medium, a mycoplasma culture method and application, and relates to the technical field of microbial materials. The human mycoplasma pneumoniae culture medium comprises a basic culture medium, fetal calf serum, ampicillin sodium and an additive, and the additive comprises the following components based on the total volume of the human mycoplasma pneumoniae culture medium: 0.8-1.6 mg / L of glutamic acid, 0.4-1.2 mg / L of cysteine, 0.6-1.4 mg / L of glutathione, 50-150 mM / L of sodium pyruvate and 50-200 mL / L of a yeast extract. And the pH value of the human mycoplasma pneumoniae culture medium after sterilization is 7.6-8.0. According to the invention, the growth and reproduction speed of the mycoplasma pneumoniae is accelerated through the synergistic effect of the specific additive composition and content and the whole culture medium, a large number of mycoplasma pneumoniae wet thalli can be obtained in a short time, the survival rate of the human mycoplasma pneumoniae is obviously improved, and the method can be widely applied to large-scale production of the human mycoplasma pneumoniae natural antigen.