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Resourceful treatment method for antibiotics mushroom dregs

A technology of antibiotic bacteria residue and treatment method, applied in the direction of solid waste removal, etc., can solve the problems of landfill method occupying large land resources, high cost of incineration method, waste of resources, etc., and achieve harmless and resource utilization, technology The effect of reliable technical parameters and reasonable process combination

Inactive Publication Date: 2016-06-08
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As a major producer of antibiotics, my country has no mature treatment technology and method for antibiotic residues. Due to its rich nutrition, crude protein content is about 40%, and various essential amino acids, vitamins and trace elements are rich and balanced. Antibiotic residues are biological It is an excellent raw material for comprehensive utilization. It is a waste of resources to directly incinerate or landfill it. Moreover, the incineration method is costly and prone to produce a large amount of harmful gases. The landfill method occupies a large amount of land resources and is easy to pollute groundwater. Therefore, the development of antibiotic bacteria The new technology of slag resource treatment is imminent
Patent CN201110409090.6 discloses a method for treating cephalosporin C production residues by thermal alkaline hydrolysis-press filtration. Although this method can eliminate antibiotic residues in cephalosporin residues, the disadvantage is that the residues only undergo one step of heating Alkaline hydrolysis, without the process of anaerobic composting, the residual solvents and metabolites in the bacterial residue cannot be converted into small molecular substances with high bioavailability
Patent CN201310095797.3 discloses a method for treating cephalosporin residues by thermal alkaline hydrolysis and anaerobic digestion. The residual biogasporin C produced by this method is extremely low, but the discharged biogas residues have not been dehydrated. It is convenient for transportation, storage and use, but has not really achieved reduction

Method used

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  • Resourceful treatment method for antibiotics mushroom dregs
  • Resourceful treatment method for antibiotics mushroom dregs
  • Resourceful treatment method for antibiotics mushroom dregs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Resource Treatment of Penicillin Residue:

[0041] Place the penicillin residue in an autoclave, and pass the high-pressure steam for the first time to flash for 8 minutes, then cool to 100°C for the first time, and pass the high-pressure steam for the second time to flash for 12 minutes, and cool to 80°C, the steam temperature is 160°C, and the pressure At 1200kPa, the bacterial residue after two-stage steam flashing is placed in the mixing tank, according to the weight ratio of bacterial residue: penicillin process wastewater: potassium dihydrogen phosphate = 250: 5: 1.5, stirring for 10 minutes, after mixing, adjust the pH value After 6 the preparation solution is obtained and enters the acid production reactor, where the acid production reactor is inoculated with anaerobic digestion sludge, the inoculation ratio is 40% by volume, the pH value is controlled to 6, the temperature is 30-40℃, and the hydraulic retention time is 30h; The effluent from the acid pro...

Embodiment 2

[0045] Example 2 Resource treatment of erythromycin residue:

[0046] Place the erythromycin slag in an autoclave, pass high-pressure steam for the first time for 5 minutes, cool to 100°C for the first time, pass high-pressure steam for the second time, flash for 15 minutes, cool to 80°C, and steam temperature of 150°C , The pressure is 1300kPa, the bacterial residue after two-stage steam flashing is placed in the mixing tank, according to the weight ratio of bacterial residue: penicillin process wastewater: potassium dihydrogen phosphate = 230: 6: 2.5, stirring for 10 minutes, after mixing, adjust the pH After the value is 6, the mixed solution is obtained and enters the acid production reactor, where the acid production reactor is inoculated with anaerobic digestion sludge, the inoculation ratio is 35% by volume, the pH value is controlled to 6, the temperature is 30-40℃, and the hydraulic retention time is 32h; the effluent from the acid production reactor enters the methanoge...

Embodiment 3

[0051] Example 3 Resource treatment of cephalosporin residue:

[0052] 4) In the dehydration section, the conditioner is a mixture of fly ash, bentonite, and calcium oxide, and its mass ratio is fly ash: bentonite: calcium oxide = (1-2): (0.5-1): (0.1- 0.3).

[0053] The cephalosporin residue is placed in an autoclave, and the high-pressure steam is introduced for the first time to flash for 6 minutes, and it is naturally cooled to 100°C, and the second time is passed into the high-pressure steam for flashing for 12 minutes, and the steam temperature is 170°C. , The pressure is 1400kPa, the bacterial residue after two-stage steam flashing is placed in the mixing tank, according to the weight ratio of bacterial residue: penicillin process wastewater: potassium dihydrogen phosphate = 220: 6: 2.2, stirring for 10 minutes, after mixing, adjust the pH After the value is 6.5, the blended solution is obtained and enters the acid production reactor. The acid production reactor is inoculat...

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Abstract

The invention provides a resourceful treatment method for antibiotics mushroom dregs, wherein mushroom dregs produced during production of antibiotics such as penicillin, erythrocin and cephalosporin are treated by the steps of intensified hydrolysis, mushroom dregs blending, two-phase anaerobic digestion, deep dehydration, resource utilization and the like. Aiming at the practical problems of a large quantity of antibiotics mushroom dregs and great treatment difficulty, the antibiotics mushroom dregs are subjected to harmless and resourceful treatment, thus providing basis for difficulties urgent to be solved of pharmaceutical enterprises.

Description

Technical field [0001] The invention belongs to the field of solid waste treatment, and specifically relates to a resource treatment method of antibiotic bacteria residue. Background technique [0002] Antibiotic mycelium waste is the waste produced by the company in the production of antibiotics. The main component of the bacterial residue is mycelium, unused culture medium (such as soybean meal, corn syrup, peanut meal, glucose, etc.), during the fermentation process Produced metabolites, degradation products of the culture medium, flocculants, acidifiers, filter aids, residual organic solvents, residual antibiotics and metabolic intermediates added during the extraction process. According to the 2008 "National Hazardous Waste List", the 2012 "Pharmaceutical Industry Pollution Prevention and Control Technology Policy", and the 2014 version of the "National Hazardous Waste List" that is being revised, antibiotic bacteria residues belong to hazardous waste. As hazardous waste, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B09B3/00
CPCB09B3/00
Inventor 刘树芹
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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