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Pretreatment method of ferment antibiotic fungi residues

A technology of antibiotic bacteria residue and pretreatment, applied in fermentation, waste fuel, etc., can solve the problems of difficult release of intracellular organic matter, difficult to fully utilize, low efficiency of methane production steps, etc., to improve efficiency, promote metabolic activity, and high-efficiency metabolism Effects of Activity and Resource Efficiency

Active Publication Date: 2017-03-08
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the anaerobic digestion of microbial cell aggregates such as bacterial residues, the hydrolysis acid production step is the rate-limiting step of anaerobic methanation, resulting in very low efficiency of the hydrogen production, acetogenic steps and methane production steps
However, due to the rigid cell wall of the mycelium in the antibiotic residue, the release of intracellular organic matter is difficult and difficult to be fully utilized. Therefore, it is necessary to take physical or chemical means to break the wall to improve the release rate of intracellular dissolved organic matter, effectively Improve the utilization rate of organic matter and biogas production rate of fungal residue

Method used

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  • Pretreatment method of ferment antibiotic fungi residues
  • Pretreatment method of ferment antibiotic fungi residues
  • Pretreatment method of ferment antibiotic fungi residues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The harmless treatment of embodiment 1 oxytetracycline bacterium slag

[0070] 1. Preparation of strains and sludge

[0071] 1-1) Preparation of thermophilic acid-producing bacteria

[0072] The thermophilic strains in Table 2 were inoculated on LB agar culture (tryptone 10g / L, yeast extract 5g / L, sodium chloride 10g / L, agar 15-20g / L, pH7), respectively, at 55°C Under anaerobic culture; then select the colonies with good growth status (big colonies) and inoculate them in fresh LB liquid medium (tryptone 10g / L, yeast extract 5g / L, sodium chloride 10g / L, pH7 ), anaerobic enrichment culture at 55°C until the biomass of the strains in the liquid medium increased to (1-2)×10 8Bacteria / ml; then the culture solution of 7 strains of thermophilic bacteria was mixed in proportion to obtain thermolytic acid-producing bacteria, which were inoculated in the reactor to start the ultra-high temperature anaerobic fermentation treatment, among which 7 strains of thermophilic bacteria ...

Embodiment 2

[0118] The harmless treatment of embodiment 2 penicillin scum

[0119] 1. Preparation of strains and sludge

[0120] 1-1) Preparation of thermophilic acid-producing bacteria

[0121] Except that the inoculation ratio of the 7 strains of thermolytic acid-producing bacteria is 0.8:1:1.2:1:1.2:0.8:1, the rest are the same as step 1-1) in Example 1.

[0122] In the present invention, Sarcina, Clostridium, Anaerobaculum, Coprothermobacter, Fervidobacterium, Caloranerobacter, the proportioning of Thermus in the thermophilic acid-producing bacteria except 0.8:1:1.2:1:1.2:0.8:1, the dosage proportioning is (0.8 -1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2) are applicable to the present invention.

[0123] 1-2) Preparation of medium temperature digested sludge and municipal surplus sludge

[0124] Medium temperature digested sludge, municipal residual sludge are the same as in step 1-2) in embodiment 1;

[0125] 2. Start-up treatment of ultra-high temperature an...

Embodiment 3

[0145] The harmless treatment of embodiment 3 cephalosporin slag

[0146] 1. Preparation of strains and sludge

[0147] 1-1) Preparation of thermophilic acid-producing bacteria

[0148] Except that the inoculation ratio of the 7 strains of thermolytic acid-producing bacteria is 1:1.2:1:0.8:0.8:1:1.2, the rest are the same as step 1-1) in Example 1.

[0149] In the present invention, arcina, Clostridium, Anaerobaculum, Coprothermobacter, Fervidobacterium, Caloranerobacter, the proportioning of Thermus except 1:1.2:1:0.8:0.8:1:1.2 in the thermophilic acid-producing bacteria, the dosage proportioning is (0.8 -1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2):(0.8-1.2) are applicable to the present invention.

[0150] 1-2) Preparation of medium temperature digested sludge and municipal surplus sludge

[0151] Medium temperature digested sludge, municipal residual sludge are the same as in step 1-2) in embodiment 1;

[0152] 2. Start-up treatment of ultra-high temperature ...

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Abstract

The invention discloses a pretreatment method of ferment antibiotic fungi residues. The pretreatment method comprises ultrahigh temperature reinforced acidogenic fermentation treatment of the ferment antibiotic fungi residues. Thermophilic hydrolysis acid-forming bacteria are used for performing high temperature anaerobic digestion treatment on the ferment antibiotic fungi residues, so that the fungi residues are hydrolyzed and acidified, antibiotic producing bacteria in the fungi residues are inactivated, and retained antibiotics are degraded. The fungi residues pretreated through the method can be directly subjected to subsequent biochemical treatment after being subjected to antibiotic removal. According to the method disclosed by the invention, the antibiotic producing bacteria can be completely killed, the antibiotics in the fungi residues can be removed, inhibition of high-concentration antibiotics to microorganisms is reduced, the difficulty in treatment of the fungi residues based on the subsequent biochemical method is reduced, generation of drug-resistant fungi and drug-resistant genes in the subsequent biochemical treatment is reduced, the harmless treatment efficiency of the antibiotic fungi residues is improved, and environmental protection is facilitated.

Description

technical field [0001] The invention relates to a method for harmless treatment of waste in the pharmaceutical industry, in particular to a method for harmless treatment of antibiotic residue produced by fermentation, and belongs to the field of solid waste treatment. Background technique [0002] Antibiotic residues are solid wastes produced during the production of antibiotics, and their main components are mycelium aggregates of antibiotic-producing bacteria, residual culture medium, metabolites produced during fermentation, degradation products of the culture medium, and a small amount of antibiotics. Wait. Due to the residual medium and a small amount of antibiotics and their degradation products in antibiotic residues, there is potential harm to the ecological environment, and has been regarded as one of the main public hazards of antibiotic production by the international community. Antibiotic residues contain a certain amount of antibiotic residues and are listed as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P5/02
CPCC12P5/023Y02E50/30
Inventor 张昱田哲杨敏高迎新丁然
Owner RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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