538 results about "Cell metabolism" patented technology

The present invention includes 1) a novel formulation for the treatment of hair loss comprising oleanolic acid (a 5α-reductase inhibitor), apigenin (a vasodilator), and biotinyl-GHK (a cell metabolism stimulant), 2) a novel additive for the treatment of hair loss comprising oleanolic acid, apigenin, biotinyl-GHK and a delivery agent, 3) a personal care, cosmetic, and/or dermopharmaceutical composition comprising oleanolic acid, apigenin, biotinyl-GHK, and at least one additional ingredient, and 4) a method for treating hair loss comprising the administration of oleanolic acid, apigenin, and biotinyl-GHK.

The invention relates to a novel measurement method and the device thereof, which combines the time-resolved self-fluorescence lifetime imaging technology and a laser scanning confocal ophthalmoscopeand realizes the early diagnosis of the ocular fundus diseases by obtaining and analyzing the self-fluorescence intensity and the service life information of the ocular fundus. The light which is emitted by a pulse laser is sent to the scanning head of the laser scanning confocal ophthalmoscope to excite the ocular fundus inner-source flgorgen, and the fluorescence which is emitted from the ocularfundus is collected by a time-correlated single photon counter or a high-repetition-rate synchronous scanning camera, so as to realize the service life measurement and the imaging of the self-fluorescence. As the service life of the self-fluorescence of the ocular fundus is very sensitive to the micro-environment and the cell metabolism state of flgorgen molecule and is not affected by the difference of the intensity of the flgorgen of the ocular fundus, the measurement of the fluorescence service life provides a brand new route for the detection of ocular fundus diseases and the obtainment of the function information of ocular fundus. The invention can become the solution and the basis of the early diagnosis of various ocular fundus diseases, which plays an important role in pathogeny research, clinical diagnosis, staging and typing, prognosis judgement, real-time observation and the analysis of the development of ocular fundus diseases, therefore the invention can be widely appliedin the field of medical research and clinical medical diagnosis.

The invention discloses preparation and application of human-stem-cell-secreted bioactive factors and a lysis solution. The process comprises the following steps of: extracting stem cells of the umbilical cord or the placenta tissue of a health human person; performing in-vitro culture and amplification; and preparing high-purity and high-activity stem-cell-secreted bioactive factors and bioactive substances in the stem cell (namely, high-purity stem cell lysis solution) by the modern biological technologies of low-temperature separation, purification and the like. According to the invention, the bioactive factors or the substances do not contain any animal component, and can be developed into a product with a cell biological activity; after acting on the human body, the product can activate the stem cell of the organism and repair or replace damaged, lesion and old cells; and the product has the functions of regulating the cell metabolism function of the organism, enhancing the immunity of the organism, delaying the aging and the like. The human bioactive factors or the substances have great application prospect in the fields of medical science, healthcare and beauty.

The embodiments herein disclose a method of fabricating composite scaffolds for skin tissue regeneration. The methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA) are synthesized. The poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds are synthesized. The hydrogel is synthesized. The composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds is fabricated. A plurality of physico-chemical characteristics of the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds are analysed. The physico-chemical characteristics comprises mechanical properties, swelling ratio and enzymatic degradation and scanning electron microscope imaging. The fibroblast cells are encapsulated within the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds and hydrogels. The fibroblast cells are seeded on composite scaffold and PGS-PCL scaffold. The fibroblast cell viability, fibroblast cell attachment, fibroblast cell spreading, fibroblast cell proliferation and fibroblast cell metabolism are analysed in composite scaffolds, PGS-PCL scaffolds and hydrogels.

The invention relates to an anti-acne facial cream which comprises Chinese traditional medicine composition and substrate formulation; the Chinese traditional medicine composition at least contains five of the following ingredients, smilax glabra, coix seed, kudzu root, astragalus, chrysanthemum, dwarf lilyturf tuber, lucid ganoderma and giant knotweed rhizome; the Chinese traditional medicine composition contains at least five of the following ingredients by weight: 5-20% of smilax glabra, 5-40% of coix seed, 3-20% of kudzu root, 5-30% of astragalus, 3-35% of chrysanthemum, 3-40% of dwarf lilyturf tuber, 3-20% of lucid ganoderma and 3-20% of giant knotweed rhizome. The anti-acne facial cream has the advantages of preventing and treating the acne, quick effect, obvious effect, no pockmark, uneasy recurrence, being used for cosmetic whitening, having the functions of skin mildness, moisture retention and sunscreen, reducing the oil secretion and promoting the cell metabolism.

A biosensor for detecting a bioeffecting substance in a test sample includes a cell network of at least one electrically excitable cell provided on a substrate in a predetermined geometry with a predefined axonal/dendritic polarity. The at least one cell is capable of producing a signal in response to the presence of the bioeffecting substance. At least one signal transducer is provided with the substrate in a predetermined geometry and is capable of detecting the signal produced by the cell. A culture medium capable of supporting metabolism of the cell is also provided.

The invention discloses a facial mask with repairing and anti-allergic functions and a preparation method thereof, comprising component A and component B, component A comprising raw materials: propylene glycol, carbomer, glycerin, jojoba wax PEG‑120 esters, Transparent Xanthan Gum, Amino Acid Moisturizer, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Antioxidant and Deionized Water; Component B Contains Raw Materials: PH Regulator, PPG‑10 Methyl Glucose Ether, Glabridin, Citrus Peel Extract, EGF, Nano Gold, Soothing Repair Extract, Yeast Extract, Snail Secretion Filtrate Extract, Gentiana Extract, Carboxymethyl Dextran C90, 1,2‑Hexanediol, and Glacier Water. The invention improves cell metabolism speed and promotes the full-effect absorption of nutrition in skin care products. Nano gold has the functions of antibacterial, anti-inflammatory and anti-oxidation, helps skin firming, anti-wrinkle, anti-aging, can improve the activity of skin collagen, and makes the skin appear natural luster , Enhance skin anti-aging ability.

The invention discloses fluorochrome for cytolysosome positioning and a preparation method and application thereof. The preparation method of the fluorochrome compound includes the steps that a benzophenone derivative containing methyl substituents is reacted under the catalysis of Zn/TiC14, an obtained product and N-bromosuccinimide are subjected to a bromination reaction, then a product is reacted with morpholine, and the tetraphenyl ethylene derivative stain containing morpholine groups is obtained. The preparation method is easy to implement, raw materials are easy to get, and reaction conditions are mild. The obtained fluorochrome contains tetraphenyl ethylene fluorescence groups capable of gathering the activity of inducing fluorescence emission and can be used for performing specific staining on all kinds of cytolysosome. The fluorochrome has the advantages of being small in cytotoxicity, stable in cell metabolism resistance, good in photobleaching resisting effect and the like and hardly affects normal physiological activities of cells, and a new method is provided for observing the morphologic changes of cytolysosome for a long time. The fluorochrome can be widely applied to monitoring the morphology of cytolysosome, observing the apoptosis process and the like.

The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.

The invention relates to a whitening and freckle-removing skin care product capable of blocking, inhibiting and reducing melanin and a preparation method of the skin care product, in particular to a whitening and freckle-removing formula capable of blocking, inhibiting and reducing melanin. The formula comprises niacinamide, betaine, beta-glucan, a cynanchum atratum extract, a morus alba bark extract, coated saccharomyces fermentation product filtrate, a spirulina platensis extract, a chlorella vulgaris extract, an oryza sativa germ extract, a hordeum vulgare germ extract, a triticum vulgare germ extract and the like. The skin care product can block, inhibit and reduce melanin, accelerate cell metabolism, accelerate falling of melanin keratinocyte, eliminate skin aging, inhibit, delay andreduce wrinkles and have skin conditioning functions of promoting skin regeneration. The skin care product is not limited by product dosage forms, can be added to aqueous solutions, emulsions, cream,essence and the like, can have multiple purposes and makes up the obvious defect that commercial products are single in function.

The invention provides cell preservation liquid. The cell preservation liquid is prepared from the following components: 30 to 120mM of an osmotic pressure stabilizer, 2 to 6mM of a saccharide substance, 0 to 10mM of a reducing agent, 0 to 120mM of an electrolyte solution and 25 to 60mM of an amino acid; the osmotic pressure of the cell preservation liquid is 310 to 350mOsm/L. The cell preservation liquid provided by the invention can be used for effectively reducing cell metabolism and reducing low-temperature injuries under a low-temperature condition; living cells are convenient to preservein a transportation process, and functional active cells are also conveniently stored for a short period by an organization.

The invention discloses an astaxanthin mask having an oxidation-resistant effect. The astaxanthin mask is characterized by being prepared from, by weight, 5-15 parts of glycerol, 5-10 parts of honey, 5-15 parts of aloe vera extracting liquid, 2-10 parts of lemon oil, 5-10 parts of arbutin, 2-5 parts of astaxanthin, 4-10 parts of hydroxypropyl-beta-cyclodextrin, 2-5 parts of ethyl alcohol, 0.01-0.1 part of methylparaben and 30-45 parts of distilled water. The astaxanthin is entrapped in the hydroxypropyl-beta-cyclodextrin, so that the solubility of the astaxanthin in mask essence is improved. The astaxanthin mask has the very good oxidation-resistant effect, can effectively remove facial oxygen free radicals and promote cell metabolism, and makes the skin rejuvenated. In addition, the astaxanthin mask also has the effects of whitening, moisturizing, minimizing pores and the like, and keeps the skin exquisite, moisturized and smooth.

The invention discloses a double-layer skin caring emulsion and a preparing method thereof, and aims at providing an emulsion which can promote cell metabolism and is good in moisturizing effect. The emulsion is mainly prepared from disodium EDTA, polyglutamic acid, glycerol, polyethylene glycol-400, dipropylene glycol, PEG-40 hydrogenated castor oil, sodium myristoyl glutamate, PPG-25-laureth-25, cyclopentasiloxane, hydrogenated polydecene, tocopheryl acetate, caprylic/capric triglyceride, phytosteryl/octyldodecyl laupoyl glutamate, hydrogenated polyisobutene, butyrospermum fruit grease, radix scutellariae root extract, yellowish sophora root extract, glycyrrhiza inflata batal extract, verbena extract, lactobacillus/eriodictyon californicum fermentation product extract, phenoxyethanol/ethylhexylglycerin, essence and the balance deionized water. The double-layer skin caring emulsion and the preparing method belong to the technical field of cosmetics.

The invention discloses a wearable physiotherapy device with functions of emotion and sleep adjustment and skin care. The wearable physiotherapy device comprises a transverse beam and two side beams,and the two ends of the transverse beam are connected with the two side beams through corner connecting parts; the transverse beam is provided with an air fresher chamber, the tail ends of the two side beams are provided with hanging lugs and micro audio playing modules respectively, and the two corner connecting parts are provided with upper covers and light-emitting panels; the upper covers, thelight-emitting panels and the corner connecting parts define a light-emitting part mounting space, and the light-emitting part mounting space is internally provided with an LED light set, a first-stage light reflecting panel and a second-stage light reflecting panel. According to the wearable physiotherapy device, the personalized sleep adjustment can be achieved by utilizing sound, light rays and odor, and therefore the life quality of a user is significantly improved; the light rays adopted for phototherapy can be set to have specific wave bands, so that the device has the function of promoting blood circulation and cell metabolism and proliferation to achieve the effect of skin care and beautifying; meanwhile, through the combination of the emotion adjustment function of the phototherapy, the product has higher use value.

The invention relates to acne-removing refine whitening cream, comprising traditional Chinese medicine composition composed of the following components by weight percent: 5-15% of rhizoma smilacis glabrae, 5-40% of semen coicis, 3-15% of kudzu-vine root, 5-20% of astragalus root, 3-25% of chrysanthemum, 3-40% of radix ophiopogonis, 3-10% of lucid ganoderma and 3-10% of giant knot weed; the extracts of the traditional Chinese medicine components are matched with appropriate ointment, thus obtaining the finished product. The invention is used for preventing and treating whelk, has fast action, obvious effect, no acne trace after healing and difficult recrudescence, is used for whitening skin and has multifunction of tendering skin, moisturizing and explosion proofing, reducing oil secretion and promoting cell metabolism.

A night maintenance mask solution is made through dipping a liquid in mask paper, and 1000 parts of the liquid are prepared from, by weight, 0.5-3 parts of micro-molecular hyaluronic acid, 1-5 parts of an aloe extract product, 0.7-9 parts of propylene glycol, 5-50 parts of 1,2-butylene glycol, 5-30 parts of glycerin, 20-50 parts of a ginseng extract liquid, 10-50 parts of a licorice root extract liquid, 5-20 parts of rose hydrolat, 1-10 parts of ethyl ascorbic acid, 0.5-5 parts of silk peptides, 0.5-5 parts of argireline peptides, 0.5-5 parts of apple stem cells, and the balance of water. The night maintenance mask solutionis aqueous, can rapidly enter skins, can remove wrinkles, has water supplementation, water retention, restoration, nutrition supplementation, anti-inflammation, bacterium prevention, itch relief and anti-allergy effects in skins, participates in and promotes cell metabolism, relieves skin wrinkles, enhances the skin elasticity, also has the advantages of no irritation to skins and no abnormal sensation, long action time and substantial effect, and is suitable for all skin types.

The invention discloses a moisturizing cosmetic composition and application thereof. The moisturizing cosmetic composition comprises barley seed extract, almond extract, aloe extract C14-22 alcohol/C12-20 alkyl glucoside, glyceryl stearate/PEG-100 stearate, cetearyl alcohol, squalane, polydimethylsiloxane, caprylic/capric triglyceride, avocado tree fruit grease and sodium hyaluronate. Natural plants are matched according to a specific proportion, and various functional ingredients are mutually coordinated and synergistic, so that the moisturizing cosmetic composition can effectively promote cell metabolism, soften cuticle, moisten skin, inhibit tryosinase, brighten skin color and nourish nutrition, has comprehensive nursing effect and has more remarkable moisturizing effect especially.

The invention discloses a fibroin cleansing foaming agent which is composed of the following components in parts by weight: 25-30% of amino acid surfactant, 3-5% of fibroin, 5-8% of sesame oil, 1-5% of glycerol, 1-5% of 1, 2-butanediol, 1-2% of antibacterial agent and 50-60% of distilled water. The fibroin cleansing foaming agent disclosed by the invention has the advantages of realizing tenderness and nonirritant, cleaning the face effectively, providing supplement nutrients for the skin, promoting the cell metabolism, improving the skin quality, resisting the outer pollution effectively, keeping the pH value balance of the skin and enhancing the skin immunity.

The invention discloses a tencel facial mask containing a dendrobium officinale ingredient. The tencel facial mask is prepared from four components A, B, C and D. Dendrobium officinale extract is used as a main active ingredient and combined with tremella fruit body extract, saccharomyces lysate extract and herba centallae extract, and the four components are synergistic to act deeply at the bottom layer of skin to supplement moisture and enhance moisturizing ability of the skin, so that moisture content in the skin can be maintained proper, cell metabolism of the skin can be improved, and microcirculation of the skin can be regulated; moisture locking is realized while moisture supplementing, so that the skin is promoted to restore a good shielding function, moisture loss is reduced effectively, moisture is locked, long-acting moisturizing is maintained for 24h, moisturizing performance, elasticity and flexibility of the skin are improved, the skin is refined and nourished, drying and itching of the skin are relieved, and natural regulating ability of the skin restores.

The invention relates to a traditional Chinese medicine preparation for repairing striae of pregnancy or scars, prepared from traditional Chinese medicines such as leech, black morning glory seed, cape jasmine, cluster mallow root, tribulus terrestris, white morning glory seed, kuh-seng, fleece-flower root, dangshen, human placentae, long-noded pit viper, sea horse, panax pseudo-ginseng and the like as raw materials by steps of soaking in olive oil, heating and frying, filtering, adding beeswax to the filtrate, dissolving, stirring, then adding chitosan oligosaccharide and lavender essence, and stirring to prepare the ointment of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation has the effects of softening, subsiding, regenerating, promoting cell metabolism, balancing oil secretion and repairing broken fibers, has good therapeutic effects on striae of pregnancy, burn and scald scars and superficial injury, and also has the functions of accelerating skin metabolism, repairing damaged and keratinized skin, restoring and maintaining the elasticity of skin, eliminating proud flesh and the like.