15 results about "Cell regulation" patented technology

The invention discloses an environment-emotion gradient association memristive neural network circuit based on a TAP cell regulation mechanism. The environment-emotion gradient association memristive neural network circuit is composed of a hippocampus module and an amygdala kernel module. The hippocampus module comprises an environment recognition neuron module and an emotion generation neuron module; the environment recognition neuron module and the emotion generation neuron module are each composed of a weight regulation and control module adj based on a TAP cell regulation mechanism, an adder, a memristor, a resistor, an operational amplifier, a function module ABM1 and a sampling holder. Wherein the weight regulation and control module adj is composed of a voltage-controlled switch, a summator, a function module ABM2 and a function module ABM3. The almond kernel module is composed of a weight regulation and control module adj, a memristor, a resistor, an operational amplifier and a sampling holder. The provided circuit simulates the hippocampus and amygdala nucleus of the brain in structure, the regulation principle of TAP cells on neural stem cells is used for reference in a weight regulation mechanism, and bidirectional gradient associated memory of the environment and the emotion can be achieved.

This document discloses compositions for use with engineered human cells, the compositions comprising a cell regulator or a carrier encoding a cell regulator. This document describes compositions comprising engineered cells, wherein the engineered cells are engineered human cells and contain modifications that make the engineered cells more resistant to alkylating drugs or nucleoside analogs compared to non-engineered human cells. Various methods for treating diseases are provided, including methods for treating cancer in a subject by administering cell regulators and / or engineered cells as therapeutic agents.

A bispecific antibody, including: a first antibody or antigen-binding fragment thereof that specifically binds to a first antigen; a second antibody or antigen-binding fragment thereof that specifically binds to a second antigen; where the first antigen is TNFR2, and the second antigen is 4-1BB; or, the first antigen is 4-1BB, and the second antigen is TNFR2. The bispecific antibody is a T cell regulator of the tumor microenvironment, which can stimulate the proliferation of CD8+T cells, activate CD8+T cells, and release anti-tumor factors, such as IFNγ and IL2 by using a TNFR2 agonistic antibody, or can block TNF-TNFR2 and inhibit the proliferation of Treg by using a TNFR2 antagonistic antibody. The bispecific antibody can simultaneously target 4-1BB, activate the 4-1BB signaling pathway of T cells and NK cells, enhance the killing power of cytotoxic T cells and NK cells, and produce anti-tumor activity.

To provide a t-cell regulatory multimer polypeptide effective for regulating the activity of a T-cell and for regulating immune response in an individual, a method for producing the polypeptide, and a pharmaceutical composition including the T-cell regulatory multimer polypeptide.SOLUTION: Provided is a T-cell regulatory multimer polypeptide that includes an immunoregulatory polypeptide and also includes an epitope-presenting Wilms tumor peptide.SELECTED DRAWING: Figure 1A

This invention relates to the field of cell regulation technology and discloses a multi-parameter feedback-based intelligent regulation method for Chir99021-induced differentiation of dental pulp stem cells. The method includes: acquiring a dataset of the differentiation process of dental pulp stem cells and performing structured analysis to obtain a multi-parameter monitoring dataset; performing multi-dimensional assessment of cell differentiation status to obtain a differentiation status assessment characterization; obtaining drug release regulation parameters based on the differentiation status assessment characterization and historical differentiation trend data; performing multi-dimensional planning on the differentiation status assessment characterization and drug release regulation parameters to obtain a regulation strategy, and encoding and reconstructing the regulation strategy to obtain microenvironment regulation instructions; applying the microenvironment regulation instructions to obtain an optimized culture microenvironment and monitoring cell state information in the optimized culture microenvironment; and iteratively regulating the drug release regulation parameters based on the cell state information to obtain the final regulation instructions. This invention can improve the accuracy of Chir99021-induced differentiation regulation of dental pulp stem cells.

The invention discloses a multi-organ regulation and control combined nano preparation and application thereof, and belongs to the technical field of medicines. The combined nano preparation consists of a nano preparation A and a nano preparation B, the nano preparation A is a parenchymal hepatic cell regulation and control nano delivery system and is prepared from phospholipid, cholesterol, PEGylated phospholipid, DSPE-PEG-Glactase and a THR-beta agonist; and the nano preparation B is an adipose cell regulation and control nano delivery system and is prepared from phospholipid, cholesterol, PEGylated phospholipid, DSPE-PEG-CKGGRAKDC and a PPAR gamma agonist. According to the invention, malignant crosstalk formed by liver-adipose tissue axes is utilized for the first time, and a strategy for treating fatty hepatitis and hepatic fibrosis related to metabolic dysfunction by cooperatively regulating lipid metabolism balance between two organs of liver and fat by using two types of liposomes is innovatively provided; the invention provides a new strategy and way for treating metabolic liver diseases.

An object of the present invention is to provide a cyclic peptide or a salt thereof and a cyclic peptide complex or a salt thereof, which have excellent binding affinity to an FGFR protein, and to provide a culture medium composition, a material for purification, a material for labeling, a material for cell regulation, and a material for accumulation, which use the cyclic peptide or a salt thereof and the cyclic peptide complex or a salt thereof.According to the present invention, there is provided a cyclic peptide or a salt thereof, the cyclic peptide being a peptide having an amino acid sequence represented by X1-Xm-X2-Xn-X3, in which the cyclic peptide contains a cyclized portion that is cyclized via covalent bonding, and the cyclized portion includes a structure represented by Formula (2),X1 represents a glutamine residue or a histidine residue, Xm represents a peptide residue containing any 2 to 4 amino acid residues, X2 represents an alanine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a tyrosine residue, a tryptophan residue, a glutamine residue, a serine residue, a threonine residue, an asparagine residue, a glutamic acid residue, an arginine residue, or a histidine residue, Xn represents an amino acid residue or a peptide residue containing any 1 to 3 amino acid residues, and X3 represents an amino acid residue containing an aromatic residue on a side chain, in Formula (2), Z1 and Z2 each independently represent a linking group, and m represents an integer of 1 to 10.

The invention discloses a system and a method for realizing cell regulation and control based on luminous oscillation stimulation of cell nucleuses, and relates to the technical field of crossing of biotechnology and optical micro-control. The method comprises the following steps: internalizing biocompatible microspheres beside a living cell nucleus, capturing the microspheres by using an optical tweezers module, and driving a light potential well to carry out double-position high-speed alternate switching by using a parameter control unit, so as to construct a programmable optical mechanical oscillator to apply oscillation stimulation to cells in a set direction, frequency and amplitude. According to the invention, the limitation of the traditional method is broken through, and direct and controllable mechanical stimulation and observation on the cell nucleus in the living cell are realized.

The invention relates to a strong-field terahertz cell irradiator, belongs to the field of terahertz biological state regulation and control and the field of experimental technical equipment, and solves the technical problems that a cell regulation and control system based on a strong-field terahertz radiation source does not exist in the prior art and the existing system does not have a portable and movable function. The strong-field terahertz cell irradiator comprises a mounting platform, a strong-field terahertz source module and a cell irradiation module. The system is portable and movable, and is suitable for diversified scenes. The system is high in integration level, the average power of the terahertz waves is high, the monopulse terahertz energy is high, the energy of the terahertz waves irradiated on the biological substances is ensured, the high field intensity enables the terahertz waves to generate a regulation effect with the biological substances more easily, and the state regulation of the strong-field terahertz waves on the biological substances can be better researched.

An object of the present invention is to provide a cyclic peptide or a salt thereof and a cyclic peptide complex or a salt thereof, which have excellent binding affinity to an FGFR protein and excellent stability, and to provide a culture medium composition, a material for purification, a material for labeling, a material for cell regulation, and a material for accumulation, which use the cyclic peptide or a salt thereof and the cyclic peptide complex or a salt thereof.A cyclic peptide or a salt thereof, the cyclic peptide being a peptide having an amino acid sequence represented by X1-X2-X3-X4, in which the cyclic peptide contains a cyclized portion that is cyclized via covalent bonding, and the cyclized portion includes a structure represented by Formula (2),X1 represents an alanine residue, a leucine residue, an isoleucine residue, a valine residue, a phenylalanine residue, a tyrosine residue, or a threonine residue, X2 represents an amino acid residue having an aromatic residue on a side chain, X3 represents any amino acid residue, and X4 represents an alanine residue, a glycine residue, a phenylalanine residue, a tyrosine residue, a tryptophan residue, a serine residue, or a histidine residue, in Formula (2), Z1 and Z2 each independently represent a linking group, and m represents an integer of 1 to 10.

The application relates to the technical field of biomaterials, in particular to a stem cell aggregate-derived decellular extracellular matrix and application thereof in bone defect repair. The decellular extracellular matrix is formed by subjecting a 3D cell aggregate in the form of a sphere to decellularization treatment, and the 3D cell aggregate is induced to form by transferring adult bone marrow mesenchymal stem cells after culture to a low-absorption cell culture carrier. The 3D dECM has a complete three-dimensional scaffold structure and abundant pores, while retaining key extracellular matrix components such as collagen, fibronectin and laminin, and is closer to the in-vivo tissue microenvironment; the 3D dECM significantly enhances the migration ability of cells, effectively improves the stemness of BMSCs, promotes extracellular matrix synthesis, and improves the mitochondrial function of BMSCs, has excellent cell regulation ability and functional activity, and thus solves the problems of low bioactivity and insufficient bionics of traditional 2D dECM.

An object of the present invention is to provide a cyclic peptide or a salt thereof and a cyclic peptide complex or a salt thereof, which have excellent binding affinity to an FGFR protein and excellent stability, and to provide a culture medium composition, a material for purification, a material for labeling, a material for cell regulation, and a material for accumulation, which use the cyclic peptide or a salt thereof and the cyclic peptide complex or a salt thereof.A cyclic peptide or a salt thereof, the cyclic peptide being a peptide having an amino acid sequence represented by X1-Xn-X2-X3-X4, in which the cyclic peptide contains a cyclized portion that is cyclized via covalent bonding, and the cyclized portion includes a structure represented by Formula (2),X1 represents an alanine residue, a proline residue, a leucine residue, an isoleucine residue, a valine residue, a phenylalanine residue, a tyrosine residue, a tryptophan residue, an asparagine residue, a serine residue, an arginine residue, a histidine residue, or a methionine residue, Xn represents a peptide residue containing any 1 to 7 amino acid residues, X2 represents an alanine residue, a glycine residue, a leucine residue, an isoleucine residue, or a valine residue, X3 represents any amino acid residue, and X4 represents an amino acid residue having an aromatic residue on a side chain, in Formula (2), Z1 and Z2 each independently represent a linking group, and m represents an integer of 1 to 10.

Main claim: The nesting material (Fig. 1) 1, consisting of a binder preferably based on lignin or polylactic acid or plant starch with the addition of cell regulators, hardeners, and blowing agents, and with the addition of natural materials such as loam, sand, clay, and plant fibers, is characterized by having a brittle, rigid foam-like consistency, by being able to have milled channels and a milled channel system, and by being environmentally friendly, ecological, recyclable, and compostable, and by being inserted into a transparent container (Fig. 1) 2 (e.g., made of glass, plastic, etc.) that is open on at least one side and is oriented vertically or horizontally and has the shape of a cuboid (or another geometric shape, e.g., a cylinder, etc.). The container (Fig. 1) 2 has one or more access points.

Methods for enhancing CAR-T or CAR-M cell activity by modulating (e.g., activating or inhibiting) cytotoxic activity of the CAR cells over time to speed up or delay killing activity of the cells. Enhanced CAR-T or CAR-M cells prepared according to methods. Therapeutic compositions and treatment methods, such as for treating cancers, using the enhanced CAR-T or CAR-M cells. The enhanced CAR-T or CAR-M cells comprise drug-loaded nanoparticles or nanocarriers comprising a cell-penetrating peptide (WTAS or rp-182) or a fragment thereof and a modified poly(P-amino ester) (PBAE) polymer associated or assembled with one or more cell modulating agents. The cell modulating agents are released into the cytoplasm to thereby modulate the activity of the enhanced CAR-T cells or CAR-M cells.

The application discloses a kind of autotrophic denitrification multi-cell regulation device and sewage denitrification method, the multi-cell regulation device includes multiple autotrophic denitrification pools in box (1), clear water pool (2), pipeline (3) and equipment room (7), autotrophic denitrification pool is installed in the box by parallel mode between each other, the denitrification process of each autotrophic denitrification pool is independent of each other, each has independently inlet and outlet pipe, each inlet and outlet pipe is connected with PLC controller, so that autotrophic denitrification pool can be automatically regulated according to sewage treatment capacity, while the number of autotrophic denitrification pool can be adjusted according to the temperature of sewage to be treated, give the device stronger sewage treatment adaptability, reduce sewage treatment cost, while improve denitrification effect and denitrification efficiency, with good application prospect.