136 results about "Living systems" patented technology

A nanoparticle-based delivery system and methods for its use are disclosed. In one aspect, a nanoparticle-based delivery system comprising at least one molecule such as proteins, DNA / RNA or fragments thereof, carbohydrates, enzymes, chemicals, virus cells, bacteria, parts of a virus, parts of a bacteria, parts of a cell, part of a tissue, or a combination of one or more of these, which shall be referred to as immunogens, are chemically or physically combined with water soluble nanoparticles which, when administered to a living system, is capable of eliciting a desired immunological response. More particularly, the invention relates to nanoparticle-based delivery systems that are specifically engineered to enhance humoral or cellular immune response without the use of adjuvants.

The invention discloses an audio / video live broadcasting system and method, which comprises a client side of data acquisition and a live-cast server; wherein, the client side of data acquisition is arranged on the mobile communication terminal to acquire the audio / video data stream recorded by the mobile communication terminal and send the acquired audio / video data stream to the live-cast server in real-time; the received audio / video data stream is made as live-cast resource by the livecast server and is broadcast in real-time. The invention has the advantages of making the audio / video recorded by the mobile communication terminal in real-time as the livecast resource of the internet live system, broadcasting the audio / video recorded by the mobile communication terminal in real-time on the internet, and utilizing the mobile phone and other mobile communication terminals to broadcast the recorded audio / video data conveniently.

Compositions, methods and business applications of using new and recycled cardboard infused with a plurality of saprophytic (including endophytic) and mycorrhizal fungi matched with seeds of plants (including trees, vegetables, herbs and grasses) whereby the cardboard can be sprouted by end-users to start ecosystems. Such containers may have carbon-credit value for companies and consumers when planted and grown as a carbon sink or carbon offset for the photosynthetic and mycelial sequestration of carbon dioxide. The relative weight of the Life Box's added seeds and spores does not significantly affect the total weight of the infused cardboard, thus not increasing transportation costs.

While genetic engineering has undergone rapid advancement with the discovery of CRISPR / Cas9, there is room for improvement for genetic circuit control, precision (reducing circuit ‘leakiness’) and delivery into living systems. The claimed invention offers programmable and precise regulation of dCas9 functions in response to multiple molecular signals by using synthetic gene circuits, greatly expanding applications. Moreover, using the system to greatest therapeutic potential has been greatly limited by the restrictive cargo size of existing viral delivery systems. By splitting dCas9 into multiple sections, the delivery size of synthetic gene circuits is greatly reduced. By exchanging split dCas9 domains, differential regulation on one gene, or activating two different genes in response to cell-type specific microRNAs is illustrated. Practical applications of the illustrative examples include engineered sensory switches including indicators for bladder cancer as well as enhanced systems for adenovirus delivery, cellular regulation, plant cell modification and potential therapeutic applications.

The reconstruction of genetic networks in mammalian systems is one of the primary goals in biological research, especially as such reconstructions relate to elucidating not only common, polygenic human disease, but living systems more generally. The present invention provides novel gene network reconstruction algorithms that utilize naturally occurring genetic variations as a source of perturbations to elucidate the networks. The algorithms incorporate relative transcript abundance and genotypic data from segregating populations by employing a generalized scoring function of maximum likelihood commonly used in Bayesian network reconstruction problems. The utility of these novel algorithms can be demonstrated via application to gene expression data from a segregating mouse population. The network derived from such data using the novel network reconstruction algorithm is able to capture causal associations between genes that result in increased predictive power, compared to more classically reconstructed networks derived from the same data.

The invention provides a live method and system for a stream medium. The live method for the stream medium comprises the following steps: performing slicing processing on the stream medium transcribed in a real-time manner by a stream pushing terminal, and successively generating slicing files which can be independently played; updating generated information of the slicing files to an indexed file, wherein the indexed file comprises preset capacity of the information of the slicing files; uploading the indexed file and the slicing files to a server by the stream pushing terminal, and further processing the indexed file and the slicing files by the server according to need. The live system for the stream medium comprises a slicing processing module and a slicing uploading module, wherein the slicing processing module is used for performing the slicing processing on the stream medium transcribed in the real-time manner and successively generating the slicing files which can be independently played; the slicing uploading module is used for updating the generated information of the slicing files to the indexed file, the indexed file comprises the preset capacity of the information of the slicing file, and the indexed file and the slicing files are uploaded to the server. Through the use of the technical scheme of the invention, the fluctuation resistant property of the live stream medium is improved, and the data integrity is ensured.

The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and confirmation of new indications for approved drugs. Screening and detection of toxic effects of compounds also can be achieved by using the methods of the invention. The methods comprise administering isotope-labeled substrates to a living system so that the label is incorporated into molecules in a manner that reveals flux rates through metabolic pathways thought to be involved in a disease. Comparisons between living systems exposed to compounds and living systems not so exposed reveals the effects of the compounds on the flux rates through the metabolic pathways. Combinations or mixtures of compounds can be systematically screened to detect unanticipated or unintended biological actions, including synergistic actions, in the same manner.

Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites inn living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic / instrumental devices.

Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instrumentation are disclosed including mass spectrometry, LC / MS, MALDI and CE as well as direct spectroscopic on-fibre measurement.

A method for determining an ownership of for a multiple owner lock. The method includes determining potential owners of the lock by inspecting a core file of a computer system or memory of a live system to determine which threads have pointers to the lock. The method includes identifying a stack for the threads with a stack pointer pointing to the current active frame and dividing the stack into active and inactive portions. The stack information is examined for each potential owner of the lock for pointers to the lock. If the thread has a pointer to the lock in the inactive portion of the stack, the thread is removed from the set of potential owners. The method includes retrieving a waiting list for the lock, and any threads on the waiting list are removed from the set of potential owners.

The present invention relates to biochemical methods for assessing metabolic fitness and / or aerobic demands of a living system. Specifically, the rate of synthesis and turnover of the molecular components of mitochondrial mass are used to determine the aerobic capacity and / or aerobic demand of tissues or living organisms. The direct measurement of metabolic fitness and / or aerobic demand by this means can be used as an index of the efficacy of an exercise training program or other therapeutic intervention; as a medical risk factor for predicting the risk of cardiovascular disease, diabetes, death or other health outcome; or as an aid to pharmaceutical companies for drug discovery in the area of metabolic fitness, deconditioning, and oxidative biology.

Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instrumentation are disclosed including mass spectrometry, LC / MS, MALDI and CE as well as direct spectroscopic on-fibre measurement.

Embodiments of the present invention provide methods and systems for dynamically certifying components. Various entities may participate in the certification process. Operational data from live systems in use may also be collected and considered as part of the certification for a component. This information is then gathered into a database, which may be shared or made publicly available over a network, such as the Internet. In addition, in some embodiments, a proposed system may be certified. A proposed configuration may be submitted to a certification service. The certification service may then analyze the proposed system and determine whether there is a sufficient data to certify the proposed system.

The present disclosure discloses a live system, method based on a mobile terminal and a mobile terminal. The system includes: a mobile terminal and a live server. The mobile terminal is to collect a video signal and an audio signal, compress the video signal and the audio signal, package the compressed video signal and the compressed audio signal into a data stream, and transmit the data stream to a live server. The live server is to transmit the data stream to a terminal device, wherein the data stream can be directly played in the terminal device. Thus, cost of living broadcasts is reduced.

Apparatus and methods for delivering electromagnetic signals configured specifically to accelerate the asymmetrical kinetics of the binding of intracellular ions to their respective intracellular buffers, to enhance the biochemical signaling pathways plant animal and human molecules, cells, tissues, organs, portions of entire organisms and entire organisms employ for growth, repair and maintenance. Described herein are devices and methods that utilize repetitive bursts of waveforms configured to maximize the bound concentration of intracellular ions at their associated molecular buffers to enhance the biochemical signaling pathways living systems employ for growth, repair and maintenance. For example the systems and methods described herein may drive the binding of calcium to calmodulin (CaM), thereby enhancing the CaM-dependent nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) signaling pathway.

The embodiment of the invention discloses a streaming media live system based on a content delivery network (CDN), which is used for solving the problems that the efficiency of transmitting streaming media data to a user by the CDN is low and the service quality can not be ensured in the prior art; the system comprises: a CND service node for providing the streaming media data for a client, maintaining the information of an on-line client and responding to an acquiring request of the information; at least one client for acquiring the streaming media data from the CDN service node and / or acquiring the information of the on-line client from the CDN service node and the streaming media data from the on-line client and providing the streaming media data to respond to the requests of other clients. The embodiment of the invention also discloses a streaming media live method based on the CDN and a device thereof. The invention is adopted to greatly improve the efficiency of transmitting the streaming media data to the user and the service quality by the CDN.

An arrangement for inhibiting the adverse effect of an ambient time varying field having an electric component of 5 Kv / M or less and / or a magnetic component of 500 muT or less on a living system. To provide protection, at least one of the characteristic parameters of said field to which the living system is exposed is changed within time intervals of less than 10 seconds.

An automatic initial data load to a new table copy concurrently with active replication to existing table copies in an asynchronous replication group includes: initiating a data load of the new table copy; creating spill queue(s) at the new table copy; loading the data from a source table copy to the new table copy, where changes for the active table copies are applied during the loading, but changes to the new table copy are stored in a spill storage area; applying the changes in the spill storage area to the new table copy after the loading of the data is done; and removing the spill storage area after the changes have been applied to the new table copy. Thus, a new table copy is initialized into the replication group without requiring that replication be suspended at the source or any of the existing table copies during the initializing process.

The invention provides a real-time virtual-real fusion live system and method based on WebGL. The real-time virtual-real fusion live system and method based on the WebGL uses the WebGL interface to realize an effective method of real-time virtual-real fusion at the Web end. The real-time virtual-real fusion live system based on the WebGL comprises five modules: a video model generation module, a video live module, a GIS service module, a virtual-real fusion module and a scene controller module. The real-time virtual-real fusion live system based on the WebGL realizes the display effect of real-time virtual-real fusion of multiple video streams on the Web end, improves the matching accuracy of virtual-real fusion display, and has the advantages of less required resources, good cross platform compatibility and good extensibility.

The invention provides a client microbonding live processing method and device, a live server and a live system. The method comprises the steps that video data collected by each microbonder are transcoded into a first video stream and a second video stream, wherein the first video stream is corresponding to the size of a first window, and the second video stream is corresponding to the size of a second window; the first video stream of a first microbonder and the second video stream of a second microbonder are sent to a client; after a window switch request sent by the client is received, the second video stream of the first microbonder and the first video stream of the second microbonder are acquired and sent to the client who issues the request; and the request includes first and the second microbonder identifiers. According to the technical scheme provided by the invention, the microbonding live window of the client can be switched; the focus viewed by the client is changed; and the live content viewing effect of the client is enhanced.

A system and method for previewing a reboot. In one embodiment the method comprises modifying a configuration of a computer system and previewing a reboot, wherein previewing the reboot comprises comparing a current configuration of the computer system to a predicted configuration of the computer system. In an additional embodiment, the method may further comprise determining errors in the current configuration of the computer system by comparing the current configuration of the computer system to the predicted configuration of the computer system. The system incorporates the idea of a “preview” boot mode for both the operating system and it resource scripts and resources. Application of this method allows the risks associated with boot processes to be safely determined a priori. The method also allows an “instantaneous” reboot by swapping actual data structures and resources with predicted data structures and resources of the live system.

Sensors based on single-walled carbon nanotubes (SWNT) are integrated into a microfluidic system outfitted with data processing and wireless transmission capability. The sensors combine the sensitivity, specificity, and miniature size of SWNT-based nanosensors with the flexible fluid handling power of microfluidic “lab on a chip” analytical systems. Methods of integrating the SWNT-based sensor into a microfluidic system are compatible with the delicate nature of the SWNT sensor elements. The sensor devices are capable of continuously and autonomously monitoring and analyzing liquid samples in remote locations, and are applicable to real time water quality monitoring and monitoring of fluids in living systems and environments. The sensor devices and fabrication methods of the invention constitute a platform technology, because the devices can be designed to specifically detect a large number of distinct chemical agents based on the functionalization of the SWNT. The sensors can be combined into a multiplex format that detects desired combinations of chemical agents simultaneously.

Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems.

The embodiment of the invention provides a live stream switching method and device. The method comprises the following steps of: obtaining the state information of a live stream reported by a current working multimedia stream live system; and, while monitoring that the state information accords with a pre-set abnormal condition, stopping working of the current working multimedia stream live system, starting a backup multimedia stream live system to work, such that the backup multimedia stream live system is used as the new current working multimedia stream live system, and switching the live stream into the new current working multimedia stream live system. By means of the scheme, multimedia stream live services can be well provided for users; and furthermore, the availability is improved.

PCT No. PCT / AU95 / 00646 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 26, 1995 PCT Pub. No. WO96 / 10740 PCT Pub. Date Apr. 11, 1996A method and apparatus for dielectric diagnostic analysis of human and non-human cells or tissue functions by measuring the response of the cells or tissue to an applied excitation signal in a time period less than the polarization relaxation time period of a domain group of the cells or tissue under examination.

A telecommunications system testing arrangement is disclosed that verifies the operation of a large distributed system of endpoints. This test system simulates actual real-time user actions on a live system that is under test. The disclosed system may improve the testing process by (1) using the actual endpoints themselves to generate traffic / actions, and (2) monitoring the system response. The disclosed system may also be configured to automatically encode test scripts based on user actions on a endpoint device, and / or to convert specific information into variables. These variables may facilitate cross platform use of the test script.

Described is a method and system by which storage reports are generated from a volume snapshot set rather than the live volume or volumes, wherein a volume snapshot set comprises a representation or copy of one or more volume at a single point-in-time. By scanning the snapshot, a consistent file system image is obtained. Scanning may take place by enumerating a volume's directories of files, or, when available, by accessing a file system metadata of file information (e.g., a master file table) separately maintained on the volume. With some (e.g., hardware-based) snapshot technologies, the snapshot can be transported to another computing system for scanning by that other computing system, thereby avoiding burdening a live system's resources when scanning. Accurate and consistent storage reports are thus obtained at a single point in time, independent of the number of volumes being scanned.

Embodiments provide for a dynamically generated UI management tool, which is part of a hierarchical, layered system built on top of an object-relational model. It provides both common model types for system modeling, as well as transaction engines. The transaction engines allow for such things as discovery of objects within a live system into an instant space and synchronization of the instant space back to the live system, which may then be used when committing requested changes to objects. Upon gathering of object-relational information within the system, the UI can be dynamically generated showing derived relationships between objects, settings, parts, or attributes for the system, without requiring the general framework to have specific knowledge of the types, relationships, and what should be displayed. As such, a change to the specific types does not require a change to the general framework.

Embodiments provide for a dynamically generated UI management tool, which is part of a hierarchical, layered system built on top of an object-relational model. It provides both common model types for system modeling, as well as transaction engines. The transaction engines allow for such things as discovery of objects within a live system into an instant space and synchronization of the instant space back to the live system, which may then be used when committing requested changes to objects. Upon gathering of object-relational information within the system, the UI can be dynamically generated showing derived relationships between objects, settings, parts, or attributes for the system, without requiring the general framework to have specific knowledge of the types, relationships, and what should be displayed. As such, a change to the specific types does not require a change to the general framework.