30 results about "Lab-on-a-chip" patented technology

A system and method for measuring tissue. A chamber is configured to hold a liquid medium. Two attachments structures with respective tissue engaging sections are configured to hold the tissue there between inside the chamber and submerged in the liquid medium. At least one of the attachments structures is formed by a cantilever. The cantilever comprises a respective bending section formed by an elongate strip with a flat surface fixated at one end of the cantilever and configured to bend with an, opposite, free end of the cantilever in a direction normal to the flat surface. The respective tissue engaging section is connected at the free end of the cantilever to the respective bending section and configured to hold a respective part of the tissue at the free end.

The present invention provides a device consisting of one or more radio frequency coils for obtaining magnetic resonance imaging or spectra from a cell culture platform in which the radio frequency coils are either wired or wireless. In one embodiment, a multichannel receive array of coil elements is designed such that the wells of the standard 24-well plate sits nested in the holder that holds the array, and optionally, a transmit coil. In another embodiment, a micro-solenoid is incorporated around the microfluidics channel of a lab on a chip. In either implementation, the receive elements can be either solenoids, single-loop or saddle coil configuration. The device may also be designed in such a way to allow for compatibility with an electrode array.

The invention relates to the field of materials science and concerns a coil which can be present, for example, in electronic circuits or in so-called lab-on-a-chip components. The object of the present invention is to provide a coil that realizes higher magnetic flux densities, in particular with coil dimensions in the micrometer to nanometer range. The object is achieved by a coil which consists of at least one turn of a wire made of an electrically conductive material, wherein the wire has at least one notch, wherein the notch is partially guided over the wire cross-section or, when the turns of the wire of the coil lie next to one another and / or one above the other, the wire material is only partially provided with at least one notch.

A system for extracting and analysing cellular material, the system comprising an integrated lab-on-a-chip (LOC) 1 and an instrument 2. The instrument comprises an interface or recess 4 for holding th

Methods that facilitate the movement of droplets in a digital microfluidic process, such as a lab-on-a-chip system. The methods also allow for a decrease in the minimum droplet size, allowing for the use of smaller fluid droplets in the microfluidic processes. An oscillation or vibration device, such as a piezo-electric device, is used to produce an oscillation in the lab-on-a-chip that disturbs the fluid droplet, allowing easier and better movement of droplets, which allows use of smaller droplets.

Chip laboratory cartridge (1), preferably for single use, in particular for a modular medical analysis system (20), comprising a sample chamber (2), wherein a fluorescent dye (4) is contained in the sample chamber (2) and wherein the fluorescent dye (4) is adhesive to a specific target molecule.

In one embodiment, a method for isolating and detecting one or more target biomarkers on a dielectrophoresis device comprises: receiving a first biological sample containing one or more target biomarkers on a dielectrophoresis (DEP) electrode array; applying a DEP force through a specific electrode of the DEP electrode array, wherein the intensity, direction, and duration of the DEP force are specific to one or more target biomarkers of the first biological sample; and determining the amount of one or more target biomarkers of the first biological sample via a digital sensor.

The invention relates to a lab-on-chip device with a modular layout for determining a plurality of biological, molecular, chemical or physical parameters relating to soil, in particular soil health and quality. Methods for using the device are also disclosed.

A Lab-On-Chip (LOC) system includes a multi-chamber tray having at least two chambers separated by a barrier, one or more light chambers each having a top portion and a bottom portion, and configured to be coupled to each chamber of the multi-chamber tray and further configured to allow selective light from the top portion of the light chamber, while blocking surrounding light, and one or more light sources, each coupled to a top portion of a corresponding one or more light chamber, wherein each of the one or more light sources is selectively configured to provide light at a predetermined wavelength, a predetermined frequency, and a predetermined intensity.

This disclosure relates to a device including an optofluidic sensor with an integrated photodiode. A "lab-on-a-chip" includes an optofluidic sensor and components for analyzing signals from the optofluidic sensor. The optofluidic sensor includes: a substrate; a channel at least partially defined by a portion of a first material layer on the substrate; input and output fluid reservoirs in fluid communication with the channel; at least a first radiation source coupled to the substrate, adapted to generate radiation in a direction toward the channel; and at least one photodiode adjacent to and below the channel.

The photothermal material-based lab-on-a-chip, the molecular diagnosis method using same, and the molecular diagnosis apparatus using same according to the present invention enable highly efficient PCR to be performed within a short period of time without concerns regarding substrate effects. In addition, analyses of different targets can be carried out simultaneously, thereby providing an advantage of enabling multiplex diagnosis. Therefore, the photothermal material-based lab-on-a-chip, the molecular diagnosis method using same, and the molecular diagnosis apparatus using same according to the present invention can be used as point-of-care diagnostic tools requiring rapidity, accuracy, and multiplex diagnostic capability.

The present disclosure provides a cartridge for Lab-On-Chip applications. An example cartridge for Lab-On-Chip applications includes a first module that is including: at least one desiccant storage chamber, a dry-reagent storage chamber, a fluidic circuit fluidically connected to the dry-reagent storage chamber, a first air path connecting the dry-reagent storage chamber to the desiccant storage chamber and comprising a membrane that prevents liquid flow from the dry-reagent storage chamber to the desiccant storage chamber. The cartridge further comprises a second module including a container having an internal cavity for holding a liquid solution. The first module and the second module are adapted to be fluidically coupled to one another.

A 3D printed micropumping system and method is provided. The micropump incorporates an active electromagnetically actuated valve and two Hall effect sensors. Both uniquely added features allowed for better optimization of the pump's parameters through synchronizing the pumping and valve opening motions. This synchronous motion minimized fluid throttling and optimized the pumping stroke versus valve opening onset to realize the maximum possible flow rate and backpressure per consumed power (i.e., high efficiency). The resulting specific flow rates and backpressure were 11.89 ml / min·W and 693 Pa / W at 10V, respectively, the highest reported values at this scale and actuation method. Moreover, the pump's integration to lab-on-chip devices was experimentally verified. The pump's planar and modular design (i.e., versatility), combined with its efficient performance, low driving voltage, and low power consumption, qualifies it as a viable candidate for battery-operated portable point of care diagnostic chips lab-one-chip, and the emerging body-on-chip devices.

The present disclosure proposes a micro-fluidic system (100) comprising an inlet (1), an outlet (2) and one or more channels (3) arranged to provide fluid flow communication between the inlet (1) and outlet (2) and extending along a length (L) in a flow direction (FD) from the inlet (1) towards the outlet (2) The one or more channel(s) (3) comprise a first portion (31) and a second portion (32) wherein the first portion (31) is disposed in-between the inlet (1) and the second portion (32) with respect to the flow direction (FD). The first portion (35) has an Ra:Dh ratio between a surface roughness (Ra) and a hydraulic diameter (Dh) of 1:200 or higher. At the one or more channels (3), a Dh:L ratio between the hydraulic diameter (Dh) and the length (L) is within the range between 1:2 and 2:1. The present disclosure further proposes a method for in vitro thrombolysis using the system (100).

The present invention provides a flexible actuator system and application capable of dynamically and programmatically adjusting surface topological deformation, including: a chip based on surface topological deformation and a chip control unit that are communicatively connected in sequence, wherein the chip based on surface topological deformation includes a driving layer and a deformation execution layer laid successively from bottom to top, wherein the driving layer is an addressable stimulus source array, the deformation execution layer is a micro flexible actuator array, the stimulus source unit on the driving layer stimulates the deformation execution layer to generate a stimulus-responsive deformation, and a flexible elastomer film can also be laid on the actuator, and dynamic surface topography / shape control of the chip based on surface topological deformation is realized through the chip control unit and the program control unit. This new surface deformation technology has great application potential in fields such as microfluidic systems, lab-on-a-chip, intelligent human-computer interaction interfaces, robot perception and execution systems, braille displays, wearable devices, VR, AR, and the metaverse.

The present disclosure concerns open-end carbon nanotubes assembled as a microelectrode array in electrode sets / micro-electrode sets (ES / micro-ES). The ES / micro-ES includes three electrodes that are made of highly densified multi-walled carbon nanotubes fibers (HD-CNTfs) sectioned into rods embedded in an inert polymer film with exposed open ends of CNTs at the electrode-electrolyte interface. The ES / micro-ES provide miniature electrochemical sensing devices in which all electrodes are based on carbon nanomaterials. The combination of dimensions and orientation provides for highly sensitive electrochemical determination (picomolar) of different electroactive analytes in different electrolyte mediums, where even a single drop of desired analyte solution will be enough for electrochemical characterization.

The present application relates to the technical field of microfluidic biological detection, and particularly relates to a multi-target cancer detection chip based on dielectric wetting technology, which adopts a double-plate EWOD architecture, forms a sealed chamber through a gasket and fills the chamber with silicone oil, sets up a five-target three-inlet structure (sample, gold nanoparticles, microcapsule inlet), integrates a 532nm LED light source to induce surface plasmon resonance (SPR), and realizes detection in combination with a visualization module. The core innovation lies in that: the five-target parallel processing improves the throughput, the LED-SPR triggers the release of biotin from the microcapsule to enhance the signal, and the lateral flow strip develops color through the biotin-streptavidin effect. The chip solves the problems of droplet evaporation, pollution and low-efficiency mixing in the existing EWOD system, supports high-temperature processes such as DNA denaturation, can precisely control droplets to complete sample preparation, mixing and detection, realizes high-sensitivity and intuitive detection of multi-target cancer markers, and is suitable for integration into a lab-on-a-chip (LOC) system.

The present invention relates generally to the field of nucleic acid isolation on silica solid supports. In particular, disclosed herein is a novel silica-solid support binding nucleic acid buffer chemistry based on the use of small tetrameric organic compounds, such as tetramethylammonium chloride (TMAC), under acidic conditions. This novel nucleic acid purification chemistry not only purifies RNA, but also DNA, and has the potential to be implemented in a wide variety of commercial kits, from spin columns to Lab-On-A-Chip (LOC) devices, such as disposable cartridges utilizing solid phase extraction technology. Furthermore, the present method can use relatively small volumes of binding buffer and thus can be performed in such integrated or closed molecular diagnostic devices, which have the potential to allow for increased sample input volumes, which for liquid biopsy samples such as plasma or urine, can increase the chances of detecting rare nucleic acid targets.

Method for producing a welded joint 20 in a chip laboratory cartridge (40), preferably for single use, in particular for a modular medical analysis system, between a Si-chip (1) which has microcavities (13) in which active substances (14) for an analysis reaction are contained and a thermoplastic plastic carrier component (2), preferably made of polycarbonate, comprising the process steps: positioning the Si-chip (1) containing the active substances in a recess (5) of the thermoplastic plastic carrier component (2) in which the Si-chip (1) rests at least partially on the thermoplastic plastic carrier component (2), applying a hold-down force (N) to the Si-chip (1) by means of a hold-down device, producing the welded joint (20).

A chip lab cartridge, preferably for single use, in particular for a modular medical analysis system, has a layer structure with a pneumatic layer and a fluidic layer, which are arranged in layers in an extension plane and are separated by an elastic membrane. The pneumatic layer and the fluidic layer form a first cavity, which is formed in a first part in the pneumatic layer and in a second part in the fluidic layer. A first sample chamber is bounded by the elastic membrane and is formed in the first cavity, which is connected in a fluid-conducting manner to a first fluid channel and a second fluid channel formed in the fluidic layer. A liquid is introduced into the first sample chamber by the first fluid channel and / or the second fluid channel.

A filter device for an optical module for a lab-on-a-chip analysis device, in which the optical module has a light path, includes a support element, a filter support, and a drive device. The support element can be mounted in the optical module. The filter support is arranged so that it can move on the support element. The filter support also has a first filter region and a second filter region. The drive device is configured such that the filter support can move between a first position in which the first filter region is arranged in the light path, and a second position in which the second filter region is arranged in the light path.

A structure includes a lab-on-chip (LOC) sensor and frontside port and cavity features for conveying a flowable sample (fluid or gas) to a sensing element of the sensor. The cavity is confined within middle of the line (MOL) dielectric layer(s). Alternatively, the cavity includes a lower section within MOL dielectric layer(s), an upper section within back end of the line (BEOL) dielectric layer(s) in the first metal (M1) level, a divider between the sections, and a duct linking the sections. Alternatively, the cavity includes a lower portion within MOL dielectric layer(s) and an upper portion continuous with the lower portion and within BEOL dielectric layer(s) in the M1 level. Optionally, the cavity is separated from the sensing element by an additional dielectric layer and / or at least partially lined with a dielectric liner. The port extends from the top of the BEOL dielectric layers down to the cavity.

A diagnostic hub located in a toilet receives a wireless signal from a mobile device of a user and determines that the user is proximate to the toilet based on the wireless signal. An identification of the user is determined based on the wireless signal. A geolocation of the diagnostic hub is determined. Sensor data generated by biometric sensors and environmental sensors is received. The diagnostic intakes a mixture of water and urine from the toilet into an intake chamber of the diagnostic hub through an inlet line or one or more openings in a housing of the diagnostic hub. A lab-on-a-chip of the diagnostic hub executes a biochemical assay on a fluid volume of the mixture using a reagent. Substance levels present in the urine are determined based on the biochemical assay. Results based on the substance levels are determined, indicating a diagnosis of one or more diseases.

The present invention discloses a microfluidic chip device for isolating a pathogen from body fluid. The present invention also relates to a process for isolating a pathogen from the body fluid using the microfluidic chip device.

The invention relates to the technical field of micro-fluidic biological detection, in particular to a multi-target cancer detection chip based on a dielectric wetting technology, which adopts a double-plate EWOD framework, forms a sealed chamber through a gasket, is filled with silicone oil, is provided with a five-target three-inlet structure (sample, gold nanoparticle and microcapsule inlet), and is integrated with a 532nm LED light source to induce surface plasmon resonance (SPR). And detection is realized in combination with a visual module. The core innovation lies in that the flux is improved through parallel processing of five target spots, the LED-SPR triggers the microcapsule to release a biotin enhancement signal, and the lateral flow strip develops color through the action of biotin-streptavidin. The chip solves the problems of droplet evaporation, pollution and low mixing efficiency of an existing EWOD system, supports high-temperature processes such as DNA denaturation, can accurately control droplets to complete sample preparation, mixing and detection, realizes high-sensitivity and visual detection of multi-target cancer markers, and is suitable for chip laboratory (LOC) system integration.

Microfluidic devices and methods for their fabrication are described. The microfluidic devices comprise one or more enclosed microfluidic channels, wherein the internal surfaces of the microfluidic channels are modified through plasma activation and / or atmospheric pressure plasma jet treatment. The treated surfaces of the microfluidic devices can covalently attach or immobilise biomolecules or cells which is useful for applications such as an organ-on-a-chip device, lab-on-a-chip device, a separation device, a cell / biomarker-capture device, a diagnostic device, a synthesis device, or a sensor device.

The present disclosure provides a cartridge for lab-on-chip applications. An example cartridge for lab-on-chip applications includes a first module including: at least one desiccant storage compartment; a dry reagent storage chamber; a fluid circuit fluidly connected to the dry reagent storage chamber; and a first air path connecting the dry reagent storage chamber to the desiccant storage chamber and including a film preventing liquid flow from the dry reagent storage chamber to the desiccant storage chamber. The cartridge also includes a second module including a container having an interior cavity for containing the liquid solution. The first module and the second module are adapted to be fluidly coupled to each other.

Lab-on-Chip, comprising the following steps for its layer-by-layer production: - designing a printed circuit (7), mixing and reaction cavities (3) for liquids, microchannels (2) and empty spaces (15) for the placement of electronic components found in each layer by means of a computer program; - mechanically machining the various cavities and passages forming the mixing and reaction cavities (3), microchannels (2), holes (8) connecting the microchannels and voids (15) for the subsequent placement of electronic components, in one or more biocompatible substrates; - metallizing the surfaces in which the printed circuit (7) is integrated according to the design prepared in the first step with a biocompatible conductive material; - producing the printed circuit (7) by photolithography and acid attack; - Bonding the electronic components in the corresponding empty spaces (15); wherein the electronic components are actuators (11) or sensors (10). - Assembling all the layers to form the finished laboratory, wherein the metallization is carried out by adhering a pre-processed biocompatible conductive material to the biocompatible substrate by means of a resin, wherein the material is one or more of the following: aluminum, silver, gold, platinum, titanium, indium tin oxide, graphene or nitinol; and wherein the biocompatible substrate(s) comprise one or more of the following materials: polymethyl methacrylate (PMMA), polyethylene terephthalate (PET), polydimethylsiloxane (PDMS), poly-3,4-ethylenedioxythiophene (PEDOT), copolymer of a cyclic olefin (COC), polycarbonate or silicon.

Chip laboratory cartridge (1), preferably for single use, in particular for a modular medical analysis system, comprising a layer structure (25) with a pneumatic layer (2) and a fluidic layer (3), which are arranged in a layered arrangement in a plane (E) and separated by an elastic membrane (4), wherein the pneumatic layer (2) and the fluidic layer (3) form a first cavity (5a), which is formed into a first part (6) in the pneumatic layer (2) and into a second part (7) in the fluidic layer (3), wherein a first sample chamber (8a), bounded by the elastic membrane (4), is formed in the first cavity (5a), which is fluidly connected to a first fluid channel (19) and a second fluid channel (20) formed in the fluidic layer (3), wherein a liquid is introduced into the first sample chamber (8a) by means of the first fluid channel (19) and / or the second fluid channel (20). can be initiatedwherein the pneumatic layer (2) has a pneumatic channel (18) by means of which the first part (6) of the first cavity (5a) can be pressurized with a negative or positive pressure, such that the elastic membrane (4) can be variably displaced in the first cavity (5a), so that the volume of the first sample chamber (8a) can be variably adjusted between a minimum volume and a maximum volume.

A lab-on-a-chip system comprises an optical detection waveguide that has an at least partially periodic structure that is configured to couple light from surroundings of the optical detection waveguide into the optical detection waveguide. The lab-on-a-chip system furthermore also comprises a microfluidic network, wherein the microfluidic network has multiple lines and at least one reaction chamber.