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Automatic device for quantitatively distributing microfluid and using method

A quantitative distribution and microfluidic technology, applied in chemical instruments and methods, analytical materials, laboratory containers, etc., can solve the problems of difficulty in precise control of droplet size and low quantitative accuracy, and achieve simple processing and simple device structure. , the effect of improving quantitative accuracy

Inactive Publication Date: 2009-07-22
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the system is simple and has a high throughput, the difference in viscosity of different liquid phases and the influence of solid-liquid interfacial tension make it difficult to accurately control the size of droplets, and the quantitative accuracy of this method is not high.

Method used

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  • Automatic device for quantitatively distributing microfluid and using method
  • Automatic device for quantitatively distributing microfluid and using method
  • Automatic device for quantitatively distributing microfluid and using method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1. Microfluidic automatic quantitative distribution device

[0021] 1.1 Structure of the device

[0022] A structure provided by the present invention for implementing the above-mentioned microfluid automatic quantitative distribution device is as follows: figure 1 As shown, by comprising a sample liquid inlet 1, an immiscible fluid inlet 2 with the sample liquid, a fluid outlet 3, a microchannel 4 and a group of microcavity 5 located on the side of the microchannel and communicated with the microchannel A flow control chip is formed; wherein, the depth of the microcavity is greater than the depth of the microchannel.

[0023] The cross-section of the microchannel is rectangular or fan-shaped, the maximum width of the cross-section is 20-1000 microns, and the maximum height of the cross-section is 2-500 microns; wherein the width of the cross-section of the micro-channel is greater than its height. The shape of the microcavity is one of cylindrical, hemispheri...

Embodiment 2

[0030] Embodiment 2. The usage method of microfluidic automatic quantitative dispensing device

[0031] The microfluidic device made in Example 1 can use the following methods for quantitative distribution of microfluidic samples:

[0032] First, the aqueous phase sample liquid 8 to be quantitatively distributed is filled into the microchannel network 4 through the sample liquid inlet 1, and the sample liquid will enter the microchannel network 4 and the microcavity 5 connected thereto. After the sample liquid fills all the microcavities, the sample The liquid inlet 1 stops sampling, and the fluid 9 that is immiscible with the aqueous phase sample liquid is filled from the fluid inlet 2 at a certain flow rate, and the excess sample liquid 10 in the microchannel is removed by the shearing action of the fluid 9, wherein the fluid 9 The flow rate of the flow rate should not be too high, and it should be ensured that its shearing effect on the sample droplet in the microcavity is ...

Embodiment 3

[0033] Embodiment 3. The usage method of microfluidic automatic quantitative dispensing device

[0034] The microfluidic device made in Example 1 can also use the following methods for quantitative distribution of microfluidic samples:

[0035] The aqueous phase sample liquid 8 to be quantitatively distributed and the fluid 9 immiscible with it are filled into the microchannel network 4 through the sample liquid inlet 1 and the fluid inlet 2 at the same time, and the sample liquid 8 at the intersection of the microchannel 7 will be due to the fluid 9 The shearing effect is dispersed into droplets, and when the droplets flow through the microcavity, the surface tension will cause the droplets to enter the microcavity until the microcavity is full, and the excess sample liquid 10 suspended in the microchannel will be under the shear of the fluid 9 It is cut off under the action of cutting, so that only the microcavity is filled with the sample liquid 11, so that the quantitative...

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Abstract

The invention discloses a method and a device for automatically and quantitatively distributing a microfluid. The method uses surface tension of liquid in a leading position under a micron scale to be combined with flow shearing action of the other fluid which is insoluble with the fluid so as to make a sample liquid filled and positioned in a microcavity with certain volume, thereby realizing quantitative distribution of the sample liquid. The device by the method is formed by at least one microchannel and a group of micro-fluidic chips of the microcavity, wherein the microcavity is positioned on the side of the microchannel and is communicated with the microchannel; the sample liquid in the microchannel enters and is filled in the microcavity through the surface tension; and then, residual sample liquid in the microchannel is removed by the flow shearing action of the other fluid which is insoluble with the liquid, and the sample liquid is just filled in the microcavity, so that quantitation and distribution of sample liquid droplet can be realized. The invention provides simple, quick and high-flux method and device for automatically and quantitatively distributing the microfluid, and can be applied to a micro-biochemical reactor and a chip laboratory.

Description

technical field [0001] The invention relates to a microfluid automatic quantitative distribution device and a using method, which can be applied to microbiochemical reactors and chip labs. Background technique [0002] In recent years, microfluidic chips, as a new technology platform, have received widespread attention in the fields of biology and chemistry, because compared with macroscopic systems, microfluidic chips have many outstanding advantages in practical applications, such as: (1) Low cost: Due to the miniaturization of the fluid system, the amount of reagents and samples required in the detection analysis and reaction synthesis process is greatly reduced (usually in nanoliters or picoliters), and the energy consumption is lower, which reduces the operating cost; on the other hand, the system The integration and automation of the system greatly reduces the manual participation and thus reduces the labor cost. (2) Fast speed: The short diffusion path and large surf...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N35/00
Inventor 李刚陈强李俊君赵建龙
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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