50 results about "Micromixer" patented technology

A micromixer, a sorter device, and a method for manufacturing fiber are provided. The micromixer includes a first portion configured to provide a first flow passage, and a second portion configured to provide a second flow passage branched from a middle of the first flow passage, wherein an inner wall of the second flow passage has a spiral shape along a longitudinal direction of the second portion.

The present invention provides a method for producing a refolded protein, the method comprising a step for mixing, inside a micro mixer, a buffer and a solubilization solution for a protein that has lost higher order structure or that has become insoluble.

To provide a fully-continuous synthesis method of glyphosate.SOLUTION: In the present invention, high-purity glyphosate is prepared by using a fully-continuous system in which a feed pump, a plurality of micromixers, a plurality of microchannel reactors, a dynamic rotary reactor, a buffer tank, a back pressure valve, a continuous reaction-kettle-type reactor, and a continuous crystallizer are sequentially connected, in which glycine is used as a raw material.EFFECT: According to the present invention, stable fully-continuous industrial production is achieved, no external intervention is required during the process, the efficiency of time and space is high, the number of operators and the labor intensity are greatly reduced, the production cost is greatly reduced, complicated operations in the conventional reaction-vessel process, a rapid rise of temperature in the kettle and the risk of material ejection are avoided, production safety is improved, the quality of glyphosate products is ensured, the operation of the apparatus is stable, the reaction time is short, the reaction yield is high, and the quality of the product is stable.SELECTED DRAWING: Figure 1

The invention relates to a precursor material production apparatus and to a method using same for producing precursor materials for high-purity, large-volume and homogeneously doped optical fiber preforms. The invention relates to a precursor material production apparatus and to a method using same for producing precursor materials for high-purity, large-volume and homogeneously or deliberately heterogeneously doped optical fiber preforms, which enable homogeneous doping in optical fiber preforms when the constituents of the precursor material are being mixed, such that no quality problems arise in the optical fibers drawn from the preforms. The invention is characterized in that a reactant (211) in the form of a first constituent and a suspension (221) in the form of a second constituent of the precursor material (6) are mixed in the precursor material production apparatus so that the first constituent can be fed via a first inlet opening (3a) and the second constituent can be fed via at least one further inlet opening (3b) to a mixing system (3) in a manner that allows metering, with the result that the first constituent and the second constituent are mixed in the mixing system (3) into a mixed material that is homogeneously or deliberately heterogeneously enriched with the dopant and that can be fed for further processing as precursor material (6), wherein the apparatus (1) is a microfluidic system which comprises at least two reservoirs (21) for the reactant (211) and the suspension (221), and at least two fluid channels (2), wherein each fluid channel (2) runs out of a reservoir (21) and, via the inlet openings (3a, 3b), into the mixing system (3), where the reactant (211) and the suspension (221), each of which is in a fluid, are intimately mixed in the form of the mixed material (6), wherein the mixer (3) is a fluidic micromixer.

A tool electrode for an EDM system for repairing a micromixer tube of a combustor, an EDM system, and a related method are provided. The tool electrode includes an elongated member; and a disk having a first side, a second side, an opening in a center thereof, and a slot extending from the first side to the second side and from the opening to an outer periphery of the disk. An elongate member is coupled to the disc and extends from a first side of the disc through the opening and beyond a second side of the disc. The discs are used to remove damaged end portions of the micromixer tubes from within the tube without debris damaging the tubes or cutting tools damaging other tubes in a set of micromixer tubes.

This invention relates to the field of drug synthesis and microchemical technology, and discloses a method for synthesizing 6-bromopenicillinic acid based on continuous flow microreactors. The method includes dissolving 6-aminopenicillinic acid in ethanol and stirring until clear to obtain liquid A; preparing an aqueous solution of sodium nitrite and hydrobromic acid to obtain liquid B; mixing liquid A and liquid B in a first micromixer and then passing them into a microreactor pipeline for diazotization and bromination reactions, with inert gas purging the pipeline online to obtain a reaction effluent; extracting the reaction effluent with dichloromethane online in a second micromixer, then separating the organic phase using a membrane phase separator, and concentrating to obtain 6-bromopenicillinic acid. This invention utilizes the advantages of efficient mixing and precise temperature control in a continuous flow microreactor, combined with inert gas purging, to achieve continuous and stable preparation. It features safe operation, good batch stability, high production efficiency, and environmental friendliness, making it suitable for industrial production.

The utility model discloses a multiphase composite micro-mixer combined with a shunting device. The multiphase composite micro-mixer comprises a mixing chip, a cover plate and an electromagnetic micro-valve, the mixing chip is provided with a mixing flow channel, and the mixing flow channel comprises a liquid inlet, a shunting and manufacturing time difference area, a mixing area and a liquid outlet which are communicated in sequence; the shunting and manufacturing time difference area comprises a shunting narrow channel and a shunting wide channel, the inner diameter of the shunting narrow channel is smaller than that of the shunting wide channel, an input port of the shunting narrow channel is communicated with an input port of the shunting wide channel, and an output port of the shunting narrow channel is communicated with an output port of the shunting wide channel; the cover plate seals and covers the mixing flow channel; the electromagnetic micro valve is used for controlling the opening and closing of the liquid outlet; the multi-phase quantitative mixing device has the advantages of high reliability, high mixing efficiency, wide application range and capability of performing multi-phase and quantitative mixing, and can play a greater role in scientific research and social life.

A micromixer for combusting a fuel-air mixture in a combustion chamber of a combustor is provided. The micromixer includes a fuel plenum, an air plenum, and a plurality of mixing tubes. Certain mixing tube(s) include a body portion made of a first material and including a first end and a second end, the first end in fluid communication with the fuel and air plenums. A cladded tip portion made of a second, different material is coupled to the second end of the body portion. The cladded tip portion includes a combustion end configured to direct the fuel-air mixture into the combustion chamber. A tapered inner surface extends from the combustion end of the cladded tip portion to a location on the body portion. The body portion has a cylindrical inner diameter from the location to the first end of the body portion.

The embodiment of the invention relates to a three-dimensional laminar flow micro mixer which comprises an inlet unit, an outlet unit and a plurality of periodically arranged micro separation and exchange units located between the inlet unit and the outlet unit, and the micro separation and exchange units are sequentially connected end to end. An inlet and an outlet of the miniature separation and exchange unit are connected through three torsion runners, laminar fluid is divided by the three torsion runners at the inlet, exchange and rearrangement of separated fluid are achieved through the three torsion runners, so that separation and exchange of the fluid are completed, and finally a new laminar fluid distribution form is formed at the outlet. And the fluid on the cross section is in two-dimensional distribution. According to the invention, rapid mixing of laminar fluid is realized by means of separation and exchange of the torsion flow channel, the structure is simple, the laser direct writing processing technology is compatible, large-scale preparation can be realized, and the device has important application in the fields of medicine, chemical industry, detection and the like.

The application provides a sequential micro-mixer based on sinusoidal vortex flow, comprising a glass substrate, a PDMS cover plate with a micro-channel arranged on the glass substrate, two 3D electrodes arranged on two sides of the micro-channel respectively, a planar electrode connected with one end of the 3D electrode and connected with an external power supply at the other end, so as to form a uniform electric field in the micro-channel through the 3D electrode, and two suspended electrodes arranged in the micro-channel and asymmetrically arranged along the fluid flow direction of the micro-channel in sequence. The sequential micro-mixer has a high-efficiency and controllable mixing effect.

The present application provides an aft plate removal tool for servicing a combustor. The combustor includes an end cover, an aft plate downstream of the end cover, and a number of tubes extending through the aft plate. The aft plate removal tool includes a base plate and a threaded rod. The base plate is attached to the end cover. Rotation of the threaded rod advances the threaded rod against the aft plate until the threaded rod pushes the aft plate off of the tubes.

The utility model discloses a tubular micro mixer for a solid-containing slurry or high-viscosity fluid system, and belongs to the field of chemical equipment design. The micro-mixer comprises a shell, a first micro-pipeline and a second micro-pipeline; the first micro-pipeline is arranged in the shell and is used for conveying solid-containing slurry or high-viscosity fluid; the second micro-pipeline is used for conveying solid-phase-free liquid; the first micro-pipeline penetrates through the second micro-pipeline in the vertical direction; the pipe section, located in the second micro-pipeline, of the first micro-pipeline is a mixing pipe section, a plurality of micropores are formed in the top of the mixing pipe section, and the diameter of the micropores is 0.2 mm-1 mm; and the second micro-pipeline is communicated with the first micro-pipeline through the micropores. The tubular micro mixer can improve the disturbance effect of collision mixing at the mixing position of a continuous phase and a dispersed phase, and realizes efficient mixing of the continuous phase and the dispersed phase, thereby improving the mixing efficiency and the mixing uniformity. The whole system can form a highly turbulent state in the pipeline, promote substance transfer and reduce deposition of solid particles, and is suitable for a complex chemical process requiring accurate control of reaction conditions.

To provide a continuous flow amination method of an alkylcarboxylic acid-based compound lower in cost, with a smaller amount of industrial waste, small in a volume of a reactor, high in safety, and stable in product quality.SOLUTION: A substituted alkylcarboxylic acid is used as a raw material. Firstly, an amination reagent and a catalyst are mixed in a micromixer, and preheated, thereafter mixed with a substituted alkylcarboxylic acid solution by a micromixer, and thereafter introduced to a dynamic continuous reactor to generate an organic amine product including a carboxylic group. A solid-containing liquid of a reaction liquid after passing through a gas-liquid separator is introduced to a multifunctional agitation vessel, and filtered twice to obtain a filtrate and a filtered cake, and the filtered cake is dried to obtain a high purity product. A first filtrate is concentrated by an inline evaporator to obtain a catalyst solution which is recovered and reused. After mixing a second filtrate and ammonia by a micromixer, the mixture is introduced to the reactor to react sufficiently, a filtrate obtained by filtration is recovered and reused as an alkali solution, and the filtered cake is an ammonium salt as a coproduct.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of pesticides, and particularly relates to a full-continuous flow production process of hymexazol. The process comprises the following steps: continuously feeding a hydroxylamine hydrochloride aqueous solution, a sodium hydroxide aqueous solution and acetoacetate raw materials into a first continuous tubular reactor through a first micro-mixer to perform a hydroxyamination reaction, then feeding a reaction solution into a second continuous fixed bed reactor, and performing a cyclization reaction under the catalysis of a solid acid catalyst, and performing post-treatment to obtain a target product. Compared with the traditional intermittent kettle type synthesis method, the process disclosed by the invention has the advantages of high yield, short reaction time, high automation degree, high space time yield, low energy consumption, small pollution and no amplification effect, and is easy for industrial production and application.

To provide a continuous flow hydrolysis method for phosphate ester and phosphite ester compounds based on a micro-reaction system.SOLUTION: High-purity phosphoric acid or phosphorous acid compounds are obtained by taking phosphate ester or phosphite ester compounds as raw materials and using a continuous micro-reaction system formed by connecting a micro-mixer, a micro-channel reactor, a back pressure valve and a gas-liquid separator through pipelines.EFFECT: By using a micro-reaction system in comparison with a traditional batch kettle type synthesis method, the method achieves high reaction efficiency, stable product quality, an order-of-magnitude increase in production capacity per unit reactor volume, and, because the reaction system is closed, avoids volatilization of organic matter and is environmentally friendly and non-toxic during the production process.SELECTED DRAWING: Figure 1

To provide a continuous-flow preparation method for an amino alcohol compound, the method belonging to the technical field of pharmaceutical engineering.SOLUTION: A micro-reaction system comprising a micro-mixer, a micro-channel reactor, and a back pressure device that are sequentially connected is used. The preparation step includes introducing a raw material aldehyde and an amine simultaneously into the micro-mixer to mix and obtain a mixed reaction material, introducing the mixed reaction material into the micro-channel reactor to undergo an addition reaction, and collecting the reaction mixture flowing out of the reactor and subjecting it to concentration and separation purification treatment to obtain an amino alcohol compound. The method has short reaction time, high energy utilization efficiency, low environmental pollution, and is applicable to industrial scale-up.SELECTED DRAWING: Figure 1

A fully-continuous synthesis method of cyproterone acetate is provided. 4-androstene-3,17-dione is adopted as a starting material. The present disclosure adopts a fully continuous device composed of micromixers, microreactors, online gravity separation units, online solvent switching units, online solvent concentration units and solvent recovery systems connected according to a cyproterone acetate synthesis route. Cyproterone acetate product is synthesized through one enzymatic catalytic reaction, nine chemical reactions and continuous operations. This can realize recovery of dichloromethane, dichloroethane and ethanol, and significantly reduce emission of three wastes. The obtained crude cyproterone acetate is subjected to decolorization, recrystallization, filtration and drying to obtain pure cyproterone acetate with a purity greater than 99%.

The utility model discloses a wedge-shaped barrier passive micromixer, and belongs to the technical field of microfluidics. The mixer comprises two fluid inlets, a fluid outlet, a micro-mixer main channel and a wedge-shaped obstacle arranged in the channel, the wedge-shaped obstacle is formed by combining a straight triangular prism and a right-angle triangular prism, the bottom face of the straight triangular prism is an isosceles right triangle, and the inclined face of the wedge-shaped obstacle faces the fluid flowing direction and always faces the central axis of the micro-mixer main channel. And the four side plates are sequentially arranged on the four sides of the rectangular main channel at equal intervals in the clockwise direction. Every four wedge-shaped barriers form a mixing unit and are circularly arranged to a fluid outlet along a main channel of the micro-mixer to form a multi-dimensional vortex, so that the fluid contact area and convective diffusion are increased, and the mixer has efficient and stable mixing performance. The micro-scale fluid mixing device is simple in structure, low in manufacturing cost and suitable for mixing occasions of micro-scale fluid such as micro-fluidic chips and the like.

This invention discloses a high-efficiency micromixer with an alternating coarse and fine sinusoidal structure and its fabrication method. The micromixer, formed through scribing, etching, plasma treatment, and encapsulation, features microchannels with varying opening widths. These microchannels are sinusoidal in shape, with the upper opening wider than the bottom. The longitudinal cross-sections of the microchannels include V-shaped sections and trapezoidal sections (wider at the top and narrower at the bottom). According to design requirements, the longitudinal cross-sections of the microchannels gradually transition between V-shaped and trapezoidal sections, with corresponding alternating depths, thus creating the alternating coarse and fine sinusoidal structure. The fabrication method of this invention is simple and easy to operate, with low cost. By controlling the formation of amorphous material during the scribing process, the resulting three-dimensional sinusoidal micromixer enhances liquid convection, significantly improving mixing efficiency and effectively enhancing the application performance of microfluidic chips. It can be widely used in the production of microfluidic chips.

The invention provides a filling type tubular micro mixer and application thereof. The mixer comprises a feeding pipe body; the mixing pipe body is connected with the feeding pipe body in series; the mixing pipe body comprises grading pipe bodies which are connected in series; the grading pipe body comprises a mixing pipe cavity, and turbulent flow particles are filled in the grading pipe body in a layered mode. Each layer of turbulent flow particles are consistent in size; the sizes and the numbers of the turbulent flow particles of adjacent layers are different; fluid channels are formed between the inner wall of the mixing pipe cavity and the outer walls of the turbulent flow particles and between the outer walls of the adjacent turbulent flow particles, so that fluid is disturbed; and the temperature control jacket is arranged on the outer side of the mixing pipe body. The technical problem to be solved is how to provide the filling type tubular micro mixer, so that fluid is more fully mixed, the reaction is quicker, and the reaction yield is improved. When the catalyst is used for continuous preparation of nitrochlorobenzene, the specific surface area is larger, local mass transfer and heat transfer are better, temperature is controlled in a segmented manner, local overheating is inhibited, the conversion rate of chlorobenzene and the yield of mononitrochlorobenzene are increased, and the generation of explosive poly-nitrochlorobenzene by-products is reduced.

The invention provides a device and a method for efficiently synthesizing 1-chloropinacolone, and belongs to the technical field of chemical synthesis. According to the method, the characteristic that chlorine has good solubility in an organic solvent is utilized, and a gas-liquid heterogeneous reaction process of a traditional kettle type process can be changed into a liquid-liquid homogeneous reaction process. Chlorine and an organic solvent are respectively fed into two feed ports and one discharge port of the micro-mixer, and the chlorine and the organic solvent are rapidly mixed into a liquid-phase solution; and the discharge port is connected with the feed port of the rotary microreactor. The rotary microreactor is provided with two feed ports and a discharge port, and the feed ports are used for feeding a chlorine source solution and a raw material pinacolone solution from the micromixer; and the discharge hole is connected with a delay pipe. The method has the characteristics of simple operation, short reaction time, high product selectivity and high yield.

This invention relates to a multi-stage injection micro-mixer structure suitable for the miscibility of scCO2 and coatings. This structure effectively solves the problems of unsatisfactory miscibility in the mixing process of scCO2 and oil-soluble coatings in existing technologies, improving the coating spraying effect and quality. The structure includes coating channels, multiple scCO2 channels, and connecting holes. By utilizing the multi-stage injection of scCO2 with gradually increasing diameter connecting holes, scCO2 is injected into the coating channels in a small-scale, multi-stage manner, achieving miscibility with the coating. Simultaneously, multiple inclined baffles are arranged on the inner wall of the coating channels to introduce flow disturbances, increase the Reynolds number and flow rate of the coating fluid, and promote effective mixing of the coating and scCO2. This invention not only achieves highly efficient miscibility between scCO2 and coatings but also avoids clogging problems caused by high fluid resistance, improving coating spraying efficiency and quality, reducing coating consumption and cost, reducing environmental pollution, and increasing operational flexibility and applicability.

The invention relates to the technical field of perovskite synthesis, in particular to a method for continuously synthesizing ion-doped perovskite nanocrystals based on an acoustic micro-mixer, which comprises the following steps: respectively injecting a perovskite precursor solution, an anti-solvent and an ion-doped precursor solution into the acoustic micro-mixer through three independent inlets of the acoustic micro-mixer; the side wall of a micro-channel of the acoustic micro-mixer is provided with periodically distributed sharp edge structures and bubble capturing grooves, and the perovskite precursor solution, the anti-solvent and the doped ion precursor solution are controlled to be mixed in the micro-channel to obtain the La < 3 + > doped CsPbxLa1-xBr3 (0.5 lt; xlt; and (1.0) standing the nanocrystalline colloidal solution, washing, and centrifuging to obtain the La < 3 + > doped CsPbxLa < 1-x > Br3 nanocrystalline. According to the method, ion doping and micro-mixing technologies are combined, so that the problems of low mixing efficiency, difficulty in controlling the doping proportion and more byproducts in a traditional doping process are solved, and efficient and accurate synthesis of the perovskite nanocrystals is realized.

A stabilizer for a plurality of mixing tubes of a micromixer includes a first member including a plurality of first openings defined therein. Each first opening receives a respective one of the plurality of mixing tubes. A second member includes a plurality of second openings defined therein. Each second opening receives a respective one of the plurality of mixing tubes. A tube engagement element is positioned between the first member and the second member and selectively engages an outer surface of the plurality of mixing tubes. A linear actuator selectively moves the second member and the first member together to engage the tube engagement therebetween with an outer surface of the plurality of mixing tubes to stabilize the plurality of mixing tubes. The tube engagement element may include an elastomeric member, or a collet positioned around each of the plurality of mixing tubes.

A method for fully continuous-flow preparation of a nitroimidazole antimicrobial agent using a fully continuous-flow system is provided herein. The method adopts a raw material of a glyoxal aqueous solution, an acetaldehyde aqueous solution and an ammonium hydroxide solution followed by multi-step chemical reactions and continuous post-treatments to yield a nitroimidazole antimicrobial agent with a high purity. The fully continuous-flow system for implementing the method includes a plurality of micromixers, a plurality of microreactors, a plurality of back pressure valves, a plurality of gas-liquid separators, a first plurality of online solvent switching units and a feed unit.

The application discloses a passive micro-mixer with a cardioid function structure, which comprises a first fluid inlet channel (1), a second fluid inlet channel (2), a preliminary mixing channel (3), a micro-mixer unit group (M), and an outlet channel (4). The micro-mixer unit group comprises a plurality of cardioid function micro-mixer units (5) which are sequentially and smoothly connected in a head-to-tail mode. The combined channel formed by the main channels of the first and second cardioid function micro-mixer units has a structure of gradually shrinking first and then gradually expanding. The cardioid function micro-mixer unit comprises a main channel, a first branch channel (8) and a second branch channel (9). The application causes the fluid to generate secondary flow and different scale vortices in the main channel, and the branch channels continuously branch and converge the fluid, intensify the unbalanced collision between the fluids, generate chaotic convection and vortex-induced mixing flow, improve the mixing strength, shorten the flow path length, reduce the mixing time, and improve the mixing effect.

Fuel injection for hydrogen-gas fuels poses risks with regard to emissions, flashback, and flame-holding events in a gas turbine engine. Accordingly, embodiments of a fuel injection system are disclosed that uniformly mix gas and fuel, while stabilizing a flame and facilitating maintenance. The fuel injection system may comprise a plurality of micromixer panels, mounted in windows of a frame that are arranged circumferentially around a longitudinal axis of the gas turbine engine. Each micromixer panel may comprise a plurality of axial channels, arranged around a central pilot body that is fixed in a grommet. Two or more internal fuel feeds may supply fuel to distinct subsets of fuel jets within the outlets of the axial channels, such that the fuel injection system may be operated in multiple stages.

The object of the present invention is to provide a method for producing compounds used in the manufacture of electronic components in high yield and high purity. [Solution] A method for producing compounds used in the manufacture of electronic components using a continuous apparatus, wherein the continuous apparatus includes a synthesis reactor in which two or more liquid compositions are mixed in a micromixer and then reacted in a reaction tube, a washing extractor, and a salt exchange reactor, and the synthesis reactor, the washing extractor, and the salt exchange reactor are connected in series in sequence via a pipeline, and the washing extractor is performed multiple times in the washing extractor.

The invention relates to the technical field of pharmaceutical engineering, in particular to a microwave continuous flow debenzylation method. The method comprises the following steps: mixing a benzyl-containing raw material solution and a debenzylation reagent by a sample injection pump through a micromixer, and pumping the mixture into a microwave continuous flow microchannel reactor to carry out a continuous flow debenzylation reaction. Compared with the prior art, the microwave technology is particularly suitable for being used in combination with a microchannel continuous flow reactor, multi-dimensional control over the reaction retention time, the mixing efficiency, the reaction temperature and the reaction pressure can be achieved, the mass transfer / heat transfer rate is increased, and miniaturization, automation and high-flux amplification of the process are achieved. According to the method, the reaction time can be shortened to several minutes, the technological process is high in continuous automation degree and space time yield, operation is easy and convenient, production is safe, cost is low, and industrial production is easy.

To provide a fully-continuous synthesis device for glyphosate that has high production efficiency, high and stable product quality, and low emissions of the three wastes (exhaust gas, wastewater, and solid waste).SOLUTION: A fully-continuous synthesis device for glyphosate matched to a glyphosate synthesis route is provided, in which a multistage continuous reaction system is used and seven feed pumps, four micromixers, six microchannel reactors, three stirring vessels, one buffer tank, two back pressure valves, and one continuous crystallizer are sequentially connected according to the glyphosate synthesis route.SELECTED DRAWING: Figure 1