95 results about "Micromixer" patented technology

The invention belongs to the field of nano material preparation, and particularly relates to a preparation method of water-soluble heme, which adopts an anti-solvent precipitation method, accurately controls an anti-solvent precipitation process through an ultrasonic microreactor or a micromixer, and realizes continuous preparation of water-soluble heme with small size, high solid content and excellent stability. The particle size of the water-soluble heme obtained through the preparation method is 200 nm or below, the solid content in water can reach 200-500 mg / mL, and the water-soluble heme can be used as a health care product or a food additive.

One aspect of the present disclosure relates to an IC structure. The IC structure includes a die and an integrated heat sink structure disposed above the die. In some embodiments, the integrated heat sink structure includes a first closed-loop microchannel structure adjacent to the die and a second closed-loop microchannel structure disposed above the first closed-loop microchannel structure. In one example, the second closed-loop microchannel structure is disposed farther from the die than the first closed-loop microchannel structure. In some implementations, multiple microchannels and a micromixer chamber collectively form the first and second closed-loop microchannel structures.

The present application provides an aft plate removal tool (100) for servicing a combustor (25), the combustor (25) including an aft plate (78) with a central passage (86) and a number of tubes (92) extending through the aft plate (78). The aft plate removal tool (100) includes a central screw (210), a lower housing (220) attached to the central screw (210), the lower housing (220) including a number of spring loaded lower housing feet (260) and an upper housing (230) attached to the center screw (210), the upper housing (230) including a number of spring loaded upper housing feet (290). The aft plate removal tool (100) is inserted through the central passage (86) of the aft plate (78) such that rotation of the upper housing (230) advances the spring loaded upper housing feet (290) against the aft plate (78) until the spring loaded upper housing feet (290) push the aft plate (78) off of the tubes (92).

A micromixer, a sorter device, and a method for manufacturing fiber are provided. The micromixer includes a first portion configured to provide a first flow passage, and a second portion configured to provide a second flow passage branched from a middle of the first flow passage, wherein an inner wall of the second flow passage has a spiral shape along a longitudinal direction of the second portion.

The present invention provides a method for producing a refolded protein, the method comprising a step for mixing, inside a micro mixer, a buffer and a solubilization solution for a protein that has lost higher order structure or that has become insoluble.

The invention provides a three-dimensional spiral spherical passive micro-mixer and a manufacturing method thereof. The three-dimensional spiral spherical structure micro-mixer mainly comprises an inlet, an outlet, a spiral mixing channel and a spherical chamber, the mixing performance of the micro-mixer is enhanced mainly according to random irregular movement of spirally rotated liquid in the spherical mixing chamber. The manufacturing method comprises the following steps that a high-precision 3D printer is used for printing an HIPS channel mold and a PLA pouring mold; pDMS is used for pouring the micro-mixer manufactured through 3D printing, and drying and curing are conducted; and punching the PDMS with the channel mold, and putting the PDMS into limonene to be fully soaked until the HIPS is completely dissolved. According to the method, the steps of photoetching and the like on the surface of the PDMS are not needed, so that the technological process is simplified, and the problem of high manufacturing complexity in a traditional method is solved. And meanwhile, integral processing of micro-size particles can be realized in the mixing chamber. In conclusion, the micro-mixer has the advantages of simple process and low cost, and is suitable for large-scale production.

This reaction device (10) comprises: a micromixer (15) which includes a first supply port (Inlet 1), a second supply port (Inlet 2), and a discharge port (Outlet); a first supply unit (11) which supplies a first solution that contains a precursor of metal oxide nanoparticles which contain a first metal element, a precursor of metal oxide nanoparticles which contain a second metal element that is different from the first metal element, and a first solvent to the first supply port (Inlet 1) at a first flow rate; a second supply unit (12) which supplies a second solution that contains a reactant and a second solvent to the second supply port (Inlet 2) at a second flow rate; a microchannel (16) in which one end serves as a supply end and the other end serves as a discharge end, and a fluid discharged from the discharge port (Outlet) is supplied from the supply end; and a microreactor (17) which controls at least some of the reaction conditions for the microchannel (16).

The invention relates to equipment and a method for liquid-liquid mixing enhanced catalysis in a cyclohexanone device. The equipment mainly comprises a micro mixer, a three-section reaction tower, an enhanced separator and a Venturi mixer. Oxidation liquid and alkali liquor are added into a micro-mixer to be fully mixed, discharged materials of the mixer enter a reaction tower, discharged materials of the reaction tower enter an enhanced separator, a product and waste alkali liquor are discharged from an outlet of the separator, and the waste alkali liquor enters a Venturi mixer to be mixed with new alkali liquor and then enters the micro-mixer. According to the invention, the median particle size lt of the dispersed phase liquid drops under the actual process condition can be realized; and the particle size of the dispersed phase is adjustable and controllable, so that the bias flow phenomenon of the alkali liquor in the oxidation liquid decomposition tower is effectively reduced, the recycling of the alkali liquor is realized, and the consumption of the alkali liquor is reduced by more than 10% (the alkali consumption is reduced by 50kg / t ketone). While efficient mixing is ensured, the separator is enhanced to realize separation between the product and the waste alkali liquid, and the yield is increased. Under the same treatment capacity, compared with the current common process equipment, the device disclosed by the invention is small in occupied area and high in treatment precision, and can be widely applied to the process needing mixing in the production of the petrochemical industry, so that the mixing efficiency is improved, and the particle size of a dispersed phase is adjustable and controllable.

To provide a fully-continuous synthesis method of glyphosate.SOLUTION: In the present invention, high-purity glyphosate is prepared by using a fully-continuous system in which a feed pump, a plurality of micromixers, a plurality of microchannel reactors, a dynamic rotary reactor, a buffer tank, a back pressure valve, a continuous reaction-kettle-type reactor, and a continuous crystallizer are sequentially connected, in which glycine is used as a raw material.EFFECT: According to the present invention, stable fully-continuous industrial production is achieved, no external intervention is required during the process, the efficiency of time and space is high, the number of operators and the labor intensity are greatly reduced, the production cost is greatly reduced, complicated operations in the conventional reaction-vessel process, a rapid rise of temperature in the kettle and the risk of material ejection are avoided, production safety is improved, the quality of glyphosate products is ensured, the operation of the apparatus is stable, the reaction time is short, the reaction yield is high, and the quality of the product is stable.SELECTED DRAWING: Figure 1

The present application provides an aft plate removal tool for servicing a combustor. The combustor includes an end cover, an aft plate downstream of the end cover, and a number of tubes extending through the aft plate. The aft plate removal tool includes a base plate and a threaded rod. The base plate is attached to the end cover. Rotation of the threaded rod advances the threaded rod against the aft plate until the threaded rod pushes the aft plate off of the tubes.

The invention relates to a precursor material production apparatus and to a method using same for producing precursor materials for high-purity, large-volume and homogeneously doped optical fiber preforms. The invention relates to a precursor material production apparatus and to a method using same for producing precursor materials for high-purity, large-volume and homogeneously or deliberately heterogeneously doped optical fiber preforms, which enable homogeneous doping in optical fiber preforms when the constituents of the precursor material are being mixed, such that no quality problems arise in the optical fibers drawn from the preforms. The invention is characterized in that a reactant (211) in the form of a first constituent and a suspension (221) in the form of a second constituent of the precursor material (6) are mixed in the precursor material production apparatus so that the first constituent can be fed via a first inlet opening (3a) and the second constituent can be fed via at least one further inlet opening (3b) to a mixing system (3) in a manner that allows metering, with the result that the first constituent and the second constituent are mixed in the mixing system (3) into a mixed material that is homogeneously or deliberately heterogeneously enriched with the dopant and that can be fed for further processing as precursor material (6), wherein the apparatus (1) is a microfluidic system which comprises at least two reservoirs (21) for the reactant (211) and the suspension (221), and at least two fluid channels (2), wherein each fluid channel (2) runs out of a reservoir (21) and, via the inlet openings (3a, 3b), into the mixing system (3), where the reactant (211) and the suspension (221), each of which is in a fluid, are intimately mixed in the form of the mixed material (6), wherein the mixer (3) is a fluidic micromixer.

The invention discloses a process method for continuously preparing (S)-5-oxotetrahydro-2-furancarboxylic acid, which comprises the following steps of: quickly mixing an acid solution containing L-glutamic acid and a sodium nitrite solution through a micro-mixer, and then introducing into a micro-packed bed reactor filled with a strong acid cation exchange resin catalyst for reaction, and carrying out continuous gas-liquid phase separation on an effluent mixture, collecting a solution, and carrying out post-treatment to obtain an oily crude product of (S)-5-oxotetrahydro-2-furancarboxylic acid. The method can effectively solve the problems of low production efficiency, poor process controllability, large acid consumption, unstable product quality and the like in the existing (S)-5-oxotetrahydro-2-furancarboxylic acid production process, obviously improves the yield and purity of the target product, and has the advantages of high reaction efficiency, safe and controllable process and the like.

A tool electrode for an EDM system for repairing a micromixer tube of a combustor, an EDM system, and a related method are provided. The tool electrode includes an elongated member; and a disk having a first side, a second side, an opening in a center thereof, and a slot extending from the first side to the second side and from the opening to an outer periphery of the disk. An elongate member is coupled to the disc and extends from a first side of the disc through the opening and beyond a second side of the disc. The discs are used to remove damaged end portions of the micromixer tubes from within the tube without debris damaging the tubes or cutting tools damaging other tubes in a set of micromixer tubes.

This invention relates to the field of drug synthesis and microchemical technology, and discloses a method for synthesizing 6-bromopenicillinic acid based on continuous flow microreactors. The method includes dissolving 6-aminopenicillinic acid in ethanol and stirring until clear to obtain liquid A; preparing an aqueous solution of sodium nitrite and hydrobromic acid to obtain liquid B; mixing liquid A and liquid B in a first micromixer and then passing them into a microreactor pipeline for diazotization and bromination reactions, with inert gas purging the pipeline online to obtain a reaction effluent; extracting the reaction effluent with dichloromethane online in a second micromixer, then separating the organic phase using a membrane phase separator, and concentrating to obtain 6-bromopenicillinic acid. This invention utilizes the advantages of efficient mixing and precise temperature control in a continuous flow microreactor, combined with inert gas purging, to achieve continuous and stable preparation. It features safe operation, good batch stability, high production efficiency, and environmental friendliness, making it suitable for industrial production.

The utility model discloses a multiphase composite micro-mixer combined with a shunting device. The multiphase composite micro-mixer comprises a mixing chip, a cover plate and an electromagnetic micro-valve, the mixing chip is provided with a mixing flow channel, and the mixing flow channel comprises a liquid inlet, a shunting and manufacturing time difference area, a mixing area and a liquid outlet which are communicated in sequence; the shunting and manufacturing time difference area comprises a shunting narrow channel and a shunting wide channel, the inner diameter of the shunting narrow channel is smaller than that of the shunting wide channel, an input port of the shunting narrow channel is communicated with an input port of the shunting wide channel, and an output port of the shunting narrow channel is communicated with an output port of the shunting wide channel; the cover plate seals and covers the mixing flow channel; the electromagnetic micro valve is used for controlling the opening and closing of the liquid outlet; the multi-phase quantitative mixing device has the advantages of high reliability, high mixing efficiency, wide application range and capability of performing multi-phase and quantitative mixing, and can play a greater role in scientific research and social life.

A micromixer for combusting a fuel-air mixture in a combustion chamber of a combustor is provided. The micromixer includes a fuel plenum, an air plenum, and a plurality of mixing tubes. Certain mixing tube(s) include a body portion made of a first material and including a first end and a second end, the first end in fluid communication with the fuel and air plenums. A cladded tip portion made of a second, different material is coupled to the second end of the body portion. The cladded tip portion includes a combustion end configured to direct the fuel-air mixture into the combustion chamber. A tapered inner surface extends from the combustion end of the cladded tip portion to a location on the body portion. The body portion has a cylindrical inner diameter from the location to the first end of the body portion.

The embodiment of the invention relates to a three-dimensional laminar flow micro mixer which comprises an inlet unit, an outlet unit and a plurality of periodically arranged micro separation and exchange units located between the inlet unit and the outlet unit, and the micro separation and exchange units are sequentially connected end to end. An inlet and an outlet of the miniature separation and exchange unit are connected through three torsion runners, laminar fluid is divided by the three torsion runners at the inlet, exchange and rearrangement of separated fluid are achieved through the three torsion runners, so that separation and exchange of the fluid are completed, and finally a new laminar fluid distribution form is formed at the outlet. And the fluid on the cross section is in two-dimensional distribution. According to the invention, rapid mixing of laminar fluid is realized by means of separation and exchange of the torsion flow channel, the structure is simple, the laser direct writing processing technology is compatible, large-scale preparation can be realized, and the device has important application in the fields of medicine, chemical industry, detection and the like.

The invention discloses a method for continuously synthesizing 4-bromine-3-methyl anisole, and belongs to the technical field of unsaturated halogenated hydrocarbon. Bromine and 3-methyl anisole are mixed through a micro-mixer and then enter a pipeline reactor to be subjected to bromination reaction, 4-bromine-3-methyl anisole is generated, and the 4-bromine-3-methyl anisole is continuously synthesized through the micro-mixer. The method specifically comprises the following steps: preparation of a composite catalyst, preparation of reaction materials, bromination reaction, online separation and catalyst recovery, and product refining. The bromination reaction method comprises the following steps: respectively conveying the material A and the material B to a micro-mixer, enabling reaction liquid fully mixed in the micro-mixer to enter a pipeline reactor, and carrying out bromination reaction at the reaction temperature of 4-8 DEG C under the control of a low-temperature circulating condensation bath for 20-30 minutes. The method provided by the invention solves the problems of the traditional kettle reaction and the existing continuous flow process, improves the conversion rate and selectivity of the target product, and reduces the generation of by-products.

The invention relates to a method and a device for preparing aluminum adsorbent powder, and belongs to the field of adsorbent manufacturing. The invention provides an aluminum adsorbent powder preparation method which comprises the following steps: mixing lithium chloride monohydrate and aluminum chloride hexahydrate, and adding water for dissolving to obtain a reaction solution A; adding water to dissolve sodium hydroxide to obtain a reaction solution B; mixing the reaction liquid A and the reaction liquid B by using an impinging stream micro-mixer to obtain a mixed liquid; stirring the mixed solution through a constant-temperature stirring system to obtain a turbid liquid; and carrying out suction filtration on the turbid liquid to obtain a filter cake, and washing and drying to obtain the aluminum adsorbent powder. The invention further provides an aluminum adsorbent powder preparation device. The aluminum adsorbent powder preparation device comprises a material storage system, an impinging stream micro-mixer; a constant-temperature stirring system; the material storage unit is connected with the impinging stream micro-mixer through a pipeline, and the impinging stream micro-mixer is connected with the constant-temperature stirring system through a pipeline.

The application provides a sequential micro-mixer based on sinusoidal vortex flow, comprising a glass substrate, a PDMS cover plate with a micro-channel arranged on the glass substrate, two 3D electrodes arranged on two sides of the micro-channel respectively, a planar electrode connected with one end of the 3D electrode and connected with an external power supply at the other end, so as to form a uniform electric field in the micro-channel through the 3D electrode, and two suspended electrodes arranged in the micro-channel and asymmetrically arranged along the fluid flow direction of the micro-channel in sequence. The sequential micro-mixer has a high-efficiency and controllable mixing effect.

The present application provides an aft plate removal tool for servicing a combustor. The combustor includes an end cover, an aft plate downstream of the end cover, and a number of tubes extending through the aft plate. The aft plate removal tool includes a base plate and a threaded rod. The base plate is attached to the end cover. Rotation of the threaded rod advances the threaded rod against the aft plate until the threaded rod pushes the aft plate off of the tubes.

The utility model discloses a tubular micro mixer for a solid-containing slurry or high-viscosity fluid system, and belongs to the field of chemical equipment design. The micro-mixer comprises a shell, a first micro-pipeline and a second micro-pipeline; the first micro-pipeline is arranged in the shell and is used for conveying solid-containing slurry or high-viscosity fluid; the second micro-pipeline is used for conveying solid-phase-free liquid; the first micro-pipeline penetrates through the second micro-pipeline in the vertical direction; the pipe section, located in the second micro-pipeline, of the first micro-pipeline is a mixing pipe section, a plurality of micropores are formed in the top of the mixing pipe section, and the diameter of the micropores is 0.2 mm-1 mm; and the second micro-pipeline is communicated with the first micro-pipeline through the micropores. The tubular micro mixer can improve the disturbance effect of collision mixing at the mixing position of a continuous phase and a dispersed phase, and realizes efficient mixing of the continuous phase and the dispersed phase, thereby improving the mixing efficiency and the mixing uniformity. The whole system can form a highly turbulent state in the pipeline, promote substance transfer and reduce deposition of solid particles, and is suitable for a complex chemical process requiring accurate control of reaction conditions.

To provide a continuous flow amination method of an alkylcarboxylic acid-based compound lower in cost, with a smaller amount of industrial waste, small in a volume of a reactor, high in safety, and stable in product quality.SOLUTION: A substituted alkylcarboxylic acid is used as a raw material. Firstly, an amination reagent and a catalyst are mixed in a micromixer, and preheated, thereafter mixed with a substituted alkylcarboxylic acid solution by a micromixer, and thereafter introduced to a dynamic continuous reactor to generate an organic amine product including a carboxylic group. A solid-containing liquid of a reaction liquid after passing through a gas-liquid separator is introduced to a multifunctional agitation vessel, and filtered twice to obtain a filtrate and a filtered cake, and the filtered cake is dried to obtain a high purity product. A first filtrate is concentrated by an inline evaporator to obtain a catalyst solution which is recovered and reused. After mixing a second filtrate and ammonia by a micromixer, the mixture is introduced to the reactor to react sufficiently, a filtrate obtained by filtration is recovered and reused as an alkali solution, and the filtered cake is an ammonium salt as a coproduct.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of pesticides, and particularly relates to a full-continuous flow production process of hymexazol. The process comprises the following steps: continuously feeding a hydroxylamine hydrochloride aqueous solution, a sodium hydroxide aqueous solution and acetoacetate raw materials into a first continuous tubular reactor through a first micro-mixer to perform a hydroxyamination reaction, then feeding a reaction solution into a second continuous fixed bed reactor, and performing a cyclization reaction under the catalysis of a solid acid catalyst, and performing post-treatment to obtain a target product. Compared with the traditional intermittent kettle type synthesis method, the process disclosed by the invention has the advantages of high yield, short reaction time, high automation degree, high space time yield, low energy consumption, small pollution and no amplification effect, and is easy for industrial production and application.

To provide a continuous flow hydrolysis method for phosphate ester and phosphite ester compounds based on a micro-reaction system.SOLUTION: High-purity phosphoric acid or phosphorous acid compounds are obtained by taking phosphate ester or phosphite ester compounds as raw materials and using a continuous micro-reaction system formed by connecting a micro-mixer, a micro-channel reactor, a back pressure valve and a gas-liquid separator through pipelines.EFFECT: By using a micro-reaction system in comparison with a traditional batch kettle type synthesis method, the method achieves high reaction efficiency, stable product quality, an order-of-magnitude increase in production capacity per unit reactor volume, and, because the reaction system is closed, avoids volatilization of organic matter and is environmentally friendly and non-toxic during the production process.SELECTED DRAWING: Figure 1

To provide a continuous-flow preparation method for an amino alcohol compound, the method belonging to the technical field of pharmaceutical engineering.SOLUTION: A micro-reaction system comprising a micro-mixer, a micro-channel reactor, and a back pressure device that are sequentially connected is used. The preparation step includes introducing a raw material aldehyde and an amine simultaneously into the micro-mixer to mix and obtain a mixed reaction material, introducing the mixed reaction material into the micro-channel reactor to undergo an addition reaction, and collecting the reaction mixture flowing out of the reactor and subjecting it to concentration and separation purification treatment to obtain an amino alcohol compound. The method has short reaction time, high energy utilization efficiency, low environmental pollution, and is applicable to industrial scale-up.SELECTED DRAWING: Figure 1

A fully-continuous synthesis method of cyproterone acetate is provided. 4-androstene-3,17-dione is adopted as a starting material. The present disclosure adopts a fully continuous device composed of micromixers, microreactors, online gravity separation units, online solvent switching units, online solvent concentration units and solvent recovery systems connected according to a cyproterone acetate synthesis route. Cyproterone acetate product is synthesized through one enzymatic catalytic reaction, nine chemical reactions and continuous operations. This can realize recovery of dichloromethane, dichloroethane and ethanol, and significantly reduce emission of three wastes. The obtained crude cyproterone acetate is subjected to decolorization, recrystallization, filtration and drying to obtain pure cyproterone acetate with a purity greater than 99%.

The utility model discloses a wedge-shaped barrier passive micromixer, and belongs to the technical field of microfluidics. The mixer comprises two fluid inlets, a fluid outlet, a micro-mixer main channel and a wedge-shaped obstacle arranged in the channel, the wedge-shaped obstacle is formed by combining a straight triangular prism and a right-angle triangular prism, the bottom face of the straight triangular prism is an isosceles right triangle, and the inclined face of the wedge-shaped obstacle faces the fluid flowing direction and always faces the central axis of the micro-mixer main channel. And the four side plates are sequentially arranged on the four sides of the rectangular main channel at equal intervals in the clockwise direction. Every four wedge-shaped barriers form a mixing unit and are circularly arranged to a fluid outlet along a main channel of the micro-mixer to form a multi-dimensional vortex, so that the fluid contact area and convective diffusion are increased, and the mixer has efficient and stable mixing performance. The micro-scale fluid mixing device is simple in structure, low in manufacturing cost and suitable for mixing occasions of micro-scale fluid such as micro-fluidic chips and the like.

A micromixer includes: a first channel plate where a first channel and a plurality of first branch channels are each formed by a non-through groove in a front surface, and a first confluence channel is formed by a non-through groove in a rear surface, and includes a first communication channel that communicates the first branch channels with the first confluence channel; a first lid plate that covers the front surface; a second channel plate where a second confluence channel is formed by a non-through groove in the front surface, and a second channel and a plurality of second branch each formed by a non-through groove in the rear surface, and includes a second communication channel that communicates the second branch channels with the second confluence channel; and a second lid plate that covers the rear surface of the second channel plate.

This invention discloses a high-efficiency micromixer with an alternating coarse and fine sinusoidal structure and its fabrication method. The micromixer, formed through scribing, etching, plasma treatment, and encapsulation, features microchannels with varying opening widths. These microchannels are sinusoidal in shape, with the upper opening wider than the bottom. The longitudinal cross-sections of the microchannels include V-shaped sections and trapezoidal sections (wider at the top and narrower at the bottom). According to design requirements, the longitudinal cross-sections of the microchannels gradually transition between V-shaped and trapezoidal sections, with corresponding alternating depths, thus creating the alternating coarse and fine sinusoidal structure. The fabrication method of this invention is simple and easy to operate, with low cost. By controlling the formation of amorphous material during the scribing process, the resulting three-dimensional sinusoidal micromixer enhances liquid convection, significantly improving mixing efficiency and effectively enhancing the application performance of microfluidic chips. It can be widely used in the production of microfluidic chips.