23 results about "Micromixer" patented technology

A micromixer, a sorter device, and a method for manufacturing fiber are provided. The micromixer includes a first portion configured to provide a first flow passage, and a second portion configured to provide a second flow passage branched from a middle of the first flow passage, wherein an inner wall of the second flow passage has a spiral shape along a longitudinal direction of the second portion.

The invention relates to a precursor material production apparatus and to a method using same for producing precursor materials for high-purity, large-volume and homogeneously doped optical fiber preforms. The invention relates to a precursor material production apparatus and to a method using same for producing precursor materials for high-purity, large-volume and homogeneously or deliberately heterogeneously doped optical fiber preforms, which enable homogeneous doping in optical fiber preforms when the constituents of the precursor material are being mixed, such that no quality problems arise in the optical fibers drawn from the preforms. The invention is characterized in that a reactant (211) in the form of a first constituent and a suspension (221) in the form of a second constituent of the precursor material (6) are mixed in the precursor material production apparatus so that the first constituent can be fed via a first inlet opening (3a) and the second constituent can be fed via at least one further inlet opening (3b) to a mixing system (3) in a manner that allows metering, with the result that the first constituent and the second constituent are mixed in the mixing system (3) into a mixed material that is homogeneously or deliberately heterogeneously enriched with the dopant and that can be fed for further processing as precursor material (6), wherein the apparatus (1) is a microfluidic system which comprises at least two reservoirs (21) for the reactant (211) and the suspension (221), and at least two fluid channels (2), wherein each fluid channel (2) runs out of a reservoir (21) and, via the inlet openings (3a, 3b), into the mixing system (3), where the reactant (211) and the suspension (221), each of which is in a fluid, are intimately mixed in the form of the mixed material (6), wherein the mixer (3) is a fluidic micromixer.

This invention relates to the field of drug synthesis and microchemical technology, and discloses a method for synthesizing 6-bromopenicillinic acid based on continuous flow microreactors. The method includes dissolving 6-aminopenicillinic acid in ethanol and stirring until clear to obtain liquid A; preparing an aqueous solution of sodium nitrite and hydrobromic acid to obtain liquid B; mixing liquid A and liquid B in a first micromixer and then passing them into a microreactor pipeline for diazotization and bromination reactions, with inert gas purging the pipeline online to obtain a reaction effluent; extracting the reaction effluent with dichloromethane online in a second micromixer, then separating the organic phase using a membrane phase separator, and concentrating to obtain 6-bromopenicillinic acid. This invention utilizes the advantages of efficient mixing and precise temperature control in a continuous flow microreactor, combined with inert gas purging, to achieve continuous and stable preparation. It features safe operation, good batch stability, high production efficiency, and environmental friendliness, making it suitable for industrial production.

A micromixer for combusting a fuel-air mixture in a combustion chamber of a combustor is provided. The micromixer includes a fuel plenum, an air plenum, and a plurality of mixing tubes. Certain mixing tube(s) include a body portion made of a first material and including a first end and a second end, the first end in fluid communication with the fuel and air plenums. A cladded tip portion made of a second, different material is coupled to the second end of the body portion. The cladded tip portion includes a combustion end configured to direct the fuel-air mixture into the combustion chamber. A tapered inner surface extends from the combustion end of the cladded tip portion to a location on the body portion. The body portion has a cylindrical inner diameter from the location to the first end of the body portion.

The embodiment of the invention relates to a three-dimensional laminar flow micro mixer which comprises an inlet unit, an outlet unit and a plurality of periodically arranged micro separation and exchange units located between the inlet unit and the outlet unit, and the micro separation and exchange units are sequentially connected end to end. An inlet and an outlet of the miniature separation and exchange unit are connected through three torsion runners, laminar fluid is divided by the three torsion runners at the inlet, exchange and rearrangement of separated fluid are achieved through the three torsion runners, so that separation and exchange of the fluid are completed, and finally a new laminar fluid distribution form is formed at the outlet. And the fluid on the cross section is in two-dimensional distribution. According to the invention, rapid mixing of laminar fluid is realized by means of separation and exchange of the torsion flow channel, the structure is simple, the laser direct writing processing technology is compatible, large-scale preparation can be realized, and the device has important application in the fields of medicine, chemical industry, detection and the like.

The application provides a sequential micro-mixer based on sinusoidal vortex flow, comprising a glass substrate, a PDMS cover plate with a micro-channel arranged on the glass substrate, two 3D electrodes arranged on two sides of the micro-channel respectively, a planar electrode connected with one end of the 3D electrode and connected with an external power supply at the other end, so as to form a uniform electric field in the micro-channel through the 3D electrode, and two suspended electrodes arranged in the micro-channel and asymmetrically arranged along the fluid flow direction of the micro-channel in sequence. The sequential micro-mixer has a high-efficiency and controllable mixing effect.

A fully-continuous synthesis method of cyproterone acetate is provided. 4-androstene-3,17-dione is adopted as a starting material. The present disclosure adopts a fully continuous device composed of micromixers, microreactors, online gravity separation units, online solvent switching units, online solvent concentration units and solvent recovery systems connected according to a cyproterone acetate synthesis route. Cyproterone acetate product is synthesized through one enzymatic catalytic reaction, nine chemical reactions and continuous operations. This can realize recovery of dichloromethane, dichloroethane and ethanol, and significantly reduce emission of three wastes. The obtained crude cyproterone acetate is subjected to decolorization, recrystallization, filtration and drying to obtain pure cyproterone acetate with a purity greater than 99%.

The invention provides a device and a method for efficiently synthesizing 1-chloropinacolone, and belongs to the technical field of chemical synthesis. According to the method, the characteristic that chlorine has good solubility in an organic solvent is utilized, and a gas-liquid heterogeneous reaction process of a traditional kettle type process can be changed into a liquid-liquid homogeneous reaction process. Chlorine and an organic solvent are respectively fed into two feed ports and one discharge port of the micro-mixer, and the chlorine and the organic solvent are rapidly mixed into a liquid-phase solution; and the discharge port is connected with the feed port of the rotary microreactor. The rotary microreactor is provided with two feed ports and a discharge port, and the feed ports are used for feeding a chlorine source solution and a raw material pinacolone solution from the micromixer; and the discharge hole is connected with a delay pipe. The method has the characteristics of simple operation, short reaction time, high product selectivity and high yield.

This invention relates to a multi-stage injection micro-mixer structure suitable for the miscibility of scCO2 and coatings. This structure effectively solves the problems of unsatisfactory miscibility in the mixing process of scCO2 and oil-soluble coatings in existing technologies, improving the coating spraying effect and quality. The structure includes coating channels, multiple scCO2 channels, and connecting holes. By utilizing the multi-stage injection of scCO2 with gradually increasing diameter connecting holes, scCO2 is injected into the coating channels in a small-scale, multi-stage manner, achieving miscibility with the coating. Simultaneously, multiple inclined baffles are arranged on the inner wall of the coating channels to introduce flow disturbances, increase the Reynolds number and flow rate of the coating fluid, and promote effective mixing of the coating and scCO2. This invention not only achieves highly efficient miscibility between scCO2 and coatings but also avoids clogging problems caused by high fluid resistance, improving coating spraying efficiency and quality, reducing coating consumption and cost, reducing environmental pollution, and increasing operational flexibility and applicability.

A stabilizer for a plurality of mixing tubes of a micromixer includes a first member including a plurality of first openings defined therein. Each first opening receives a respective one of the plurality of mixing tubes. A second member includes a plurality of second openings defined therein. Each second opening receives a respective one of the plurality of mixing tubes. A tube engagement element is positioned between the first member and the second member and selectively engages an outer surface of the plurality of mixing tubes. A linear actuator selectively moves the second member and the first member together to engage the tube engagement therebetween with an outer surface of the plurality of mixing tubes to stabilize the plurality of mixing tubes. The tube engagement element may include an elastomeric member, or a collet positioned around each of the plurality of mixing tubes.

A method for fully continuous-flow preparation of a nitroimidazole antimicrobial agent using a fully continuous-flow system is provided herein. The method adopts a raw material of a glyoxal aqueous solution, an acetaldehyde aqueous solution and an ammonium hydroxide solution followed by multi-step chemical reactions and continuous post-treatments to yield a nitroimidazole antimicrobial agent with a high purity. The fully continuous-flow system for implementing the method includes a plurality of micromixers, a plurality of microreactors, a plurality of back pressure valves, a plurality of gas-liquid separators, a first plurality of online solvent switching units and a feed unit.

The object of the present invention is to provide a method for producing compounds used in the manufacture of electronic components in high yield and high purity. [Solution] A method for producing compounds used in the manufacture of electronic components using a continuous apparatus, wherein the continuous apparatus includes a synthesis reactor in which two or more liquid compositions are mixed in a micromixer and then reacted in a reaction tube, a washing extractor, and a salt exchange reactor, and the synthesis reactor, the washing extractor, and the salt exchange reactor are connected in series in sequence via a pipeline, and the washing extractor is performed multiple times in the washing extractor.

This invention discloses a three-dimensional micromixer based on the DNA double helix structure, belonging to the field of microfluidics technology. The micromixer has two spatial helical channels with a π-phase difference, periodically coupled through staggered, "base pair"-like connecting channels. The centrifugal force generated by the three-dimensional helical microchannels induces Dean's vortexes, producing a "rotation-revolution" composite effect during fluid flow. Furthermore, the mass transfer between the two channels is enhanced through the splitting-recombination effect of the "base pair" connecting channels. Compared with existing technologies, this invention has the following advantages: 1. It induces complex three-dimensional flow through the three-dimensional DNA double helix structure, realizing continuous renewal and stretching of the fluid interface; 2. It utilizes the curvature and torsion of the three-dimensional helical structure to generate a "revolution" enhanced mixing effect under the superposition effect of rotation and deflection, forming a "rotation-revolution composite flow" similar to planetary motion, overcoming the mixing difficulties caused by low diffusion efficiency and difficulty in forming chaotic convection in high-viscosity oil phase systems; 3. Under the same mixing efficiency, the pressure drop of this device is much smaller than that of traditional two-dimensional planar serpentine and split-and-merge micromixers, enabling rapid and uniform mixing of high-viscosity fluids with low energy consumption, and is particularly suitable for mixing and mass transfer enhancement of high-viscosity oil phase systems in fine chemical processes.

This invention relates to the field of platinum-containing compound technology, and provides a method and apparatus for the continuous synthesis of hexahydroxyplatinic acid. The invention involves mixing sodium hydroxide solution and chloroplatinic acid solution in a micromixer, followed by reaction in a reaction coil. The reaction solution is then cooled in a cooling coil to obtain a product solution containing sodium hexahydroxyplatinate. This product solution is then acidified to obtain hexahydroxyplatinic acid. The micromixer enables millisecond-level rapid mixing of sodium hydroxide and chloroplatinic acid solutions, ensuring uniform contact of the two raw materials at the microscale. Simultaneously, the design of the reaction and cooling systems allows for precise temperature control during the reaction process, solving the problems of low heat transfer efficiency and localized overheating in traditional reaction vessels, and improving product uniformity. The method provided by this invention has good safety, achieves efficient continuous synthesis of hexahydroxyplatinic acid, is suitable for scale-up production, and has significant industrial application value and promising prospects.

A mixing system for use in a process bottle for mixing its contents, the mixing system including a low volume magnetically-driven mixer mounted at the bottom of the bottle. The mixer may have vanes and lower grooves, or no vanes and grooves on both upper and lower faces. The mixer has a “microsized” three-dimensional solid inanimate body to enable insertion through relatively small mouth openings at the top of conventional reactor bottles. Methods of assembly are also disclosed which involve passing the microsized mixer through an open mouth of a process bottle and coupling the mixer with a bearing assembly at the floor of the bottle. The bearing assembly includes fixtures sealed around a hole in the floor of the bottle.

This disclosure aims to provide a micromixer, sorter apparatus, and a method for manufacturing fibers used therein, which have novel shapes different from conventional microfluidic devices fabricated using lithography, a widely known technology for semiconductor manufacturing. [Solution] The device comprises a first part that provides a first flow path and a second part that provides a second flow path that branches off from the first flow path. The inner wall of the second flow path is spiral in shape along the longitudinal direction of the second part.

A fully-continuous flow synthesis method of glyphosate is provided, which is performed by using a fully-continuous system including a plurality of pumps, a micromixer, a plurality of microchannel reactors, a plurality of tubular reactors, two back pressure valves, a plurality of reaction vessels, and a plurality of continuous crystallizers. Paraformaldehyde is depolymerized in the presence of an organic base, and the resultant depolymerization product undergoes an addition reaction with glycine to yield N, N-dihydroxymethylglycine, which further undergoes esterification with dimethyl phosphite (added in two batches) to generate a glyphosate ester. The glyphosate ester is adjusted to be acidic, hydrolyzed, desolvated, neutralized with a base, and purified to obtain glyphosate.

This invention relates to the synthesis of methyl thioglycolate, and discloses a method and apparatus for the continuous flow synthesis of methyl thioglycolate, as well as its applications. The method includes: introducing a catalyst, methyl thioglycolate, and methanol into a micromixer for contact; introducing the resulting feedstock into a microreactor for reaction; subjecting the resulting reaction solution to a first vacuum distillation to obtain an overhead effluent and a bottom effluent; heating the overhead effluent and then subjecting it to atmospheric distillation to obtain a methanol effluent and a wastewater effluent; refluxing the methanol effluent for the contact process; heating the bottom effluent and then subjecting it to a second vacuum distillation to obtain a methyl thioglycolate product and a feedstock effluent; cooling the feedstock effluent and then refluxing for the contact process; the feedstock effluent contains unreacted methyl thioglycolate and catalyst. This method and apparatus enable the continuous preparation of methyl thioglycolate, allowing for the reuse of feedstock and catalyst, resulting in a short reaction time, minimal environmental pollution, and high purity, yield, and selectivity of the methyl thioglycolate product.

The invention relates to a method for preparing a manganese dioxide material, and the method comprises the following steps: S1, enabling a manganese source solution to enter a micro-mixer through a first constant-flux pump, and mixing the manganese source solution with an oxidizing agent entering the micro-mixer through a second constant-flux pump, so as to obtain a mixed solution; s2, enabling the mixed solution to enter a micro-channel reactor, carrying out a reaction, and recovering a solid-phase material; wherein the retention time of the reaction in the micro-channel reactor is 0.5-30 min; the ratio of the flow rate of the manganese source solution entering the first constant-flux pump to the flow rate of the oxidant entering the second constant-flux pump is 1: (0.9-1.1). According to the method provided by the invention, the synthesis time of manganese dioxide can be shortened, the synthesis efficiency and crystal form regulation and control stability are effectively improved, the prepared manganese dioxide material can be directly used for adsorption and removal of hydrogen sulfide gas, and the sulfur penetration capacity of the manganese dioxide material can reach about 190-670 mg S / g adsorbent.

The invention belongs to the technical field of crossing of pharmaceutical chemistry and chemical processes, and discloses a continuous flow synthesis method and system of a nerofloxacin malate intermediate. According to the method, through a continuous flow technology, a first liquid material flow containing 2, 4-difluoro-3-methoxybenzoyl chloride, a second liquid material flow containing N, N-dimethylamino ethyl acrylate and an optional organic alkali material flow are mixed through a first micro-mixer and then enter a first micro-channel reactor for a nucleophilic substitution reaction of 1, 4-difluoro-3-methoxybenzoyl chloride, a second liquid material flow containing N, N-dimethylamino ethyl acrylate and an optional organic alkali material flow; mixing with cyclopropylamine flow through a second micro-mixer, feeding into a second micro-channel reactor, carrying out nucleophilic substitution reaction 2, and finally quenching, separating liquid, concentrating, crystallizing and drying to obtain a target intermediate. According to the method, the problems of violent reaction, high safety risk, complicated post-treatment, remarkable amplification effect and the like of a traditional kettle type process are solved, the reaction safety, the product yield and purity are improved, the environmental protection pressure is reduced, the process is efficient and stable, and automatic amplification is easy.

The utility model belongs to the field of micro continuous chemical pharmacy, and discloses a micro mixer which comprises an upper module and a lower module, the upper module is provided with two inlet channels, the bottom surface of the upper module is provided with a first straight channel and a first bent channel, one end of the first straight channel is communicated with one inlet channel, and the other end of the first straight channel is communicated with one end of the first bent channel; the lower module is detachably connected with the upper module, the lower module is provided with an outlet channel which vertically penetrates through the lower module, the top surface of the lower module is provided with a second straight channel and a second bent channel, one end of the second straight channel is correspondingly communicated with the other inlet channel, and the other end of the second straight channel is communicated with one end of the second bent channel; the second bend and the first bend are correspondingly spliced to form an arc-shaped mixing channel, and the outlet channel communicates with the mixing channel. By arranging the first straight channel, the second straight channel and the mixing channel, the structure of the micro mixer can be simplified, a user can conveniently assemble and use the micro mixer, the flow channel layout can be optimized, and the pressure drop is effectively reduced.

A method of mixing in a microfluidic device involves: introducing a liquid into a three-phase mixing chamber in a microfluidic device, and drawing a gas by bubbling through the liquid in the mixing chamber by applying a relative pressure in the mixing chamber above the free surface of the introduced liquid, of -0.345 to -3.5 kPa. A kit with a relief-patterned substrate and a suction device for applying the negative pressure is provided. The relief patterned substrate provides chambers and channels to allow the mixing to take place when covered by at least one cover, and sealed to form a chip, with the suction device coupled to a corresponding port of the chip.

A kit for forming a microfluidic device with a microfluidic mixer 10 comprises a substrate with a cover-meeting surface having a relief pattern defining a mixing chamber, a gas inlet 15a proximate the