Barrier repair composition for activating cell energy and application thereof

Abstract

The invention relates to a barrier repair composition for activating cell energy and application thereof, the composition comprises the following components: nicotinamide, a wheat germ extract, oat beta-glucan and a golden camellia flower extract, the four components synergistically form a full-link barrier repair system of energy supply (nicotinamide)-autophagy cleaning (wheat germ extract)-structure strengthening (beta-glucan)-oxidation defense (camellia nitidissima extract), the limitation that a traditional skin care product singly supplements lipid or resists oxidation is broken through, lipid dynamic balance is rebuilt from the root of cell metabolism, and the skin care product has the advantages that the skin care effect is good; and certain skin smoothing and anti-aging effects are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, and particularly relates to a barrier repair composition for activating cell energy and its application. Background Art

[0002] The core feature of the damaged barrier of sensitive skin lies in the insufficient synthesis or structural disorder of the stratum corneum lipid matrix (such as ceramides, cholesterol, free fatty acids), resulting in an increase in transepidermal water loss rate (TEWL), easy penetration of external irritants and triggering of inflammatory reactions. Research shows that the differentiation of skin keratinocytes and lipid synthesis highly depend on the energy metabolism homeostasis in cells. As the core unit of energy supply, mitochondria generate ATP through oxidative phosphorylation and provide key raw materials for the synthesis of lipid precursors (such as acetyl-CoA, NADPH). In addition, damaged mitochondria accumulated in sensitive skin due to external stimuli (such as ultraviolet rays, chemical allergens) will continuously release reactive oxygen species (ROS), trigger lipid peroxidation and inhibit the functions of lipid synthesis-related enzymes, forming a vicious cycle of "energy deficiency - oxidative damage - lipid defect". Mitophagy can effectively reduce the production of ROS and maintain the health of the mitochondrial network by selectively removing dysfunctional mitochondria, thereby providing a stable metabolic environment for lipid synthesis. Therefore, by synergistically activating mitochondrial energy metabolism and inducing mitophagy, not only can the energy and substrate supply required for lipid synthesis be directly increased, but also the structural stability of lipids can be optimized by removing the source of oxidative damage, thereby reconstructing the dynamic balance of barrier lipids at the molecular level and restoring the healthy barrier state of sensitive skin.

[0003] Current repair strategies for damaged barriers of sensitive skin, especially in the field of skin care products, generally focus on exogenous supplementation of barrier lipids (such as ceramides, cholesterol) or strengthening physical occlusion to reduce water loss. Although these methods can improve epidermal dryness in the short term, they do not touch on the core mechanism of lipid deficiency - that is, the failure of the autonomous synthesis ability of epidermal cells due to energy metabolism disorders. Their limitation lies in simply attributing lipid deficiency to component loss and ignoring the regulatory imbalance of the intracellular endogenous biosynthesis pathway: as the core supply source of lipid precursors (such as acetyl-CoA, NADPH) and ATP, the decline of mitochondrial function will directly limit key steps such as fatty acid chain elongation and ceramide assembly, but the existing technologies rarely activate mitochondrial energy metabolism to restore the "lipid factory" function of cells. In addition, the continuous accumulation of damaged mitochondria not only exacerbates the energy crisis, but also triggers lipid peroxidation by releasing excessive ROS, resulting in unstable or even decomposed structures of newly synthesized lipids. Currently, the products on the market lack intervention means for mitochondrial quality control (such as inducing mitophagy to remove damaged units), resulting in the repair effect remaining on the surface and being unsustainable. Summary of the Invention

[0004] The object of the present invention is to overcome the deficiencies of the prior art and provide a barrier repair composition for activating cell energy and its application. Each raw material component in the composition synergizes with each other, promotes lipid synthesis by deeply stimulating cell energy and damaged mitochondrial autophagy, thereby achieving the effect of barrier repair.

[0005] To achieve the above object, the technical solution adopted by the present invention is as follows:

[0006] In the first aspect, the present invention provides a barrier repair composition for activating cell energy, comprising the following components: niacinamide, wheat germ extract, oat β-glucan, and camellia nitidissima extract. The weight ratio of niacinamide, wheat germ extract, oat β-glucan, and camellia nitidissima extract is (0.1-5):(0.1-3):(0.1-3):(0.1-5).

[0007] Niacinamide (a derivative of vitamin B3), a water-soluble vitamin, plays a core role in energy metabolism. By increasing the intracellular NAD + level, it activates mitochondrial oxidative phosphorylation, enhances the ATP generation efficiency, and provides an energy basis for the synthesis of skin barrier lipids (such as ceramides and cholesterol). In addition, niacinamide can promote microcirculation in the dermis, increase the supply of lipid precursors (such as acetyl coenzyme A), and indirectly support lipid metabolism. In skin care products, its antioxidant properties can reduce the damage of oxidative stress to the skin, while improving uneven skin tone, enhancing the barrier function, and delaying the process of photoaging.

[0008] Wheat germ extract is derived from the germ part of the plant Triticum aestivum L. of the Gramineae family, and is rich in protein, vitamin E, B vitamins, and minerals. Its core active ingredients include spermidine and polysaccharide substances, which have significant antioxidant and cell repair functions. As an autophagy inducer, it can reduce the inhibitory effect of reactive oxygen species (ROS) on lipid synthase by clearing damaged mitochondria, maintain the health of the mitochondrial network, and thus ensure continuous energy output.

[0009] Oat β-glucan is extracted from the endosperm and aleurone layer of the plant Avena sativa of the Gramineae family, and is a water-soluble polysaccharide connected by β-glycosidic bonds. Its molecular structure forms a highly viscous environment, which can form a biomimetic hydration film on the skin surface and reduce transepidermal water loss. By activating the differentiation of keratinocytes, it can accelerate the secretion of lamellar bodies to secrete lipids and strengthen the barrier structure. In addition, this component has an immunomodulatory effect, can enhance skin microcirculation and mitochondrial biosynthesis ability, form a positive feedback loop of energy metabolism with niacinamide, and at the same time has anti-inflammatory and soothing effects.

[0010] The extract of Camellia nitidissima Chi, which is from the genus Camellia of the family Theaceae and is known as the "giant panda in the plant kingdom", is rich in tea polyphenols, flavonoids, saponins and polysaccharides. Its polyphenol and flavonoid components inhibit lipid peroxidation by scavenging free radicals and protect newly formed lipids from oxidative damage. Its anti-inflammatory properties can alleviate barrier damage caused by overactivation of inflammatory factors and simultaneously repair damaged mitochondrial function. This ingredient has the functions of antioxidant, anti-aging and promoting microcirculation in skin care products, and is often used to improve skin elasticity, reduce inflammatory reactions and support overall barrier health.

[0011] Preferably, the weight ratio of the niacinamide, wheat germ extract, oat β-glucan and extract of Camellia nitidissima Chi is (1-3):(0.1-1):(0.5-2):(0.5-2).

[0012] More preferably, the weight ratio of the niacinamide, wheat germ extract, oat β-glucan and extract of Camellia nitidissima Chi is (1-2):(0.6-1):(0.8-1):(0.5-1).

[0013] In a second aspect, the present invention provides the use of the barrier repair composition for activating cell energy described in the first aspect in the preparation of skin care products.

[0014] Preferably, the skin care product is any one of lotion, emulsion, cream, facial mask, essence or spray, and the addition amount of the composition is 0.5%-5% of the total weight of the skin care product.

[0015] In a third aspect, the present invention provides an essence, which comprises the following raw materials in weight percentages: 0.5%-5% of the composition described in the first aspect, 0.05%-0.3% of a thickener, 0.5%-10% of a humectant, 0.5%-5% of a preservative, 0.01%-0.3% of a pH regulator and 0.01%-1% of a fragrance, and the balance is deionized water.

[0016] Preferably, the thickener comprises at least one of xanthan gum, carbomer, acryloyldimethyltaurate / VP copolymer, ammonium acryloyldimethyltaurate / VP copolymer, sclerotium gum, cetyl alcohol. More preferably, it is carbomer U30.

[0017] Preferably, the humectant comprises at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, hydrolyzed sodium hyaluronate, 1,2-butanediol, glycerol, pullulan, ceramide. More preferably, the humectant is a composition of glycerol, 1,2-butanediol and allantoin.

[0018] Preferably, the pH regulator includes at least one of arginine, tromethamine, and disodium EDTA. More preferably, the pH regulator is arginine.

[0019] Preferably, the preservative includes at least one of 1,2 - propanediol, 1,2 - hexanediol, and p - hydroxyacetophenone. More preferably, the preservative is 1,2 - hexanediol and p - hydroxyacetophenone.

[0020] In a fourth aspect, the present invention provides a method for preparing the essence in the third aspect, comprising the following steps:

[0021] S1. Mix the humectant, thickener, and part of the deionized water, homogenize at 75 - 85 °C, then add the preservative and stir evenly to obtain a mixture.

[0022] S2. Wait until the temperature drops to 35 - 45 °C, add each component in the composition, essence, and the remaining deionized water to the mixture obtained in step S1, stir evenly, and finally add the pH regulator to adjust the pH to obtain the essence.

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0024] The composition of the present invention includes nicotinamide, wheat germ extract, oat β - glucan, and camellia nitidissima extract. Nicotinamide, as the core energy metabolism regulator, by enhancing intracellular nicotinamide adenine dinucleotide (NAD +) Horizontally activates mitochondrial oxidative phosphorylation, significantly enhancing the ATP generation efficiency, providing an energy basis for the synthesis of barrier lipids such as ceramides and cholesterol. Meanwhile, it increases the supply of lipid precursors such as acetyl coenzyme A by promoting microcirculation in the dermis layer, directly promoting lipid synthesis. As an autophagy inducer, wheat germ extract targets and clears damaged mitochondria through activating the PINK1 / Parkin pathway, reducing the inhibition of lipid synthase by ROS generation. At the same time, it enhances the efficiency of autophagosome formation and maintains the health of the mitochondrial network to ensure continuous energy output. Oat β-glucan promotes keratinocyte differentiation by activating the TLR2 receptor, accelerating the secretion of lamellar bodies to improve the barrier structure. Its polysaccharide chain can also form a biomimetic hydration membrane to reduce transepidermal water loss. Meanwhile, it can also enhance mitochondrial biosynthesis, forming a positive feedback loop of energy metabolism with niacinamide. Camellia nitidissima extract is rich in tea polyphenols and flavonoids, inhibiting the lipid peroxidation chain reaction by scavenging free radicals, protecting newly synthesized lipids from oxidative damage. Its anti-inflammatory property can reduce the barrier damage caused by overactivation of the TRPV1 channel. Meanwhile, it can also activate and repair mitochondrial function. The four work together to form a full-link barrier repair system of "energy supply (niacinamide) - autophagy cleaning (wheat germ extract) - structural strengthening (β-glucan) - oxidative defense (Camellia nitidissima extract)", breaking through the limitations of traditional skin care products that only supplement lipids or antioxidants singly, reconstructing the lipid dynamic balance from the root of cell metabolism, and having a certain effect of smoothing the skin and anti-aging. Brief Description of the Drawings

[0025] Figure 1 It is a flow chart for extracting facial sebum of volunteers;

[0026] Figure 2 It is a comparison chart of the use of the essence in Application Example 1 and Comparative Application Example 5 (blank control group) at 0 day and 28 days. Detailed Embodiments

[0027] To better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0028] The sources of raw materials used in the following embodiments and comparative examples are as follows:

[0029] Niacinamide: The manufacturer is BASF Chemical Co., Ltd.

[0030] Wheat germ extract: The manufacturer is Shaanxi Fuheng Biotechnology Co., Ltd.

[0031] Oat β-glucan: The manufacturer is Beijing Orient Miaosen Biotechnology Co., Ltd., and the product number is Miaokexiu.

[0032] Camellia nitidissima extract: The manufacturer is SikiYuan (Xiamen) Biotechnology Co., Ltd.

[0033] Other materials, reagents, etc. used in the examples can be obtained from commercial sources without special instructions.

[0034] Example 1

[0035] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 1.5:0.8:0.9:0.7, and the total weight of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is 100 parts.

[0036] Example 2

[0037] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 1:0.6:1:1, and the total weight of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is 100 parts.

[0038] Example 3

[0039] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 2:1:0.8:0.5, and the total weight of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is 100 parts.

[0040] Example 4

[0041] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 1:0.1:0.5:2, and the total weight of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is 100 parts.

[0042] Example 5

[0043] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 3:1:2:0.5, and the total weight of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is 100 parts.

[0044] Example 6

[0045] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 5:0.1:3:0.1, and the total weight of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is 100 parts.

[0046] Example 7

[0047] A barrier repair composition for activating cell energy, comprising niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 0.1:3:0.1:5, and the total weight parts of the niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract are 100 parts.

[0048] Comparative Example 1

[0049] The difference between Comparative Example 1 and Example 1 is that: niacinamide is not added to the composition, and the missing amount is supplemented with wheat germ extract, oat β-glucan and camellia nitidissima extract in a weight ratio of 0.8:0.9:0.7.

[0050] Comparative Example 2

[0051] The difference between Comparative Example 2 and Example 1 is that: wheat germ extract is not added to the composition, and the missing amount is supplemented with niacinamide, oat β-glucan and camellia nitidissima extract in a weight ratio of 1.5:0.9:0.7.

[0052] Comparative Example 3

[0053] The difference between Comparative Example 3 and Example 1 is that: oat β-glucan is not added to the composition, and the missing amount is supplemented with niacinamide, wheat germ extract and camellia nitidissima extract in a weight ratio of 1.5:0.8:0.7.

[0054] Comparative Example 4

[0055] The difference between Comparative Example 4 and Example 1 is that: camellia nitidissima extract is not added to the composition, and the missing amount is supplemented with niacinamide, wheat germ extract and oat β-glucan in a weight ratio of 1.5:0.8:0.9.

[0056] Test Example 1: Detection of cell energy ATP synthesis ability and autophagy ability

[0057] The compositions of Examples 1-7 and Comparative Examples 1-4 were set as 11 groups of test sample groups, and the experiment was carried out according to the following steps. The specific steps are as follows:

[0058] Human keratinocytes HaCaT were revived (Guangzhou Geneo Biotechnology Co., Ltd.). The test conditions were: incubator temperature 37±1°C, humidity 90±5%, carbon dioxide 5±1% (v / v); cell culture and treatment were carried out according to the grouping, and then the test was carried out. The specific test was the expression of estrogen receptor 2 (ESR2). The test method was as follows:

[0059] (1) Inoculate the cell suspension into a 96-well cell culture plate at a density of 2,000 cells per well. Add 100 μL of high-glucose DMEM culture medium (Gibco) containing 10% fetal bovine serum to each well and culture for 24 h.

[0060] (2) Sample addition: Only add 100 μL of the culture medium to the blank control group, and add 100 μL of the culture medium containing 0.1 wt% of the composition test sample to each sample group in each group, and continue to culture for 48 h.

[0061] (3) Use a commercially available kit to test the ATP content in the cells (MedChemExpress, product number: HY-K0314). Determine the ATP content in the cells by bioluminescence method, and calculate the ATP promotion rate according to the following calculation formula. The higher the promotion rate, the better the effect of activating cell energy.

[0062] (4) Use an autophagy detection kit (abcam, product number: ab139484) to determine the number of autophagosomes in the cells by fluorescence labeling method. The autophagy ability can be determined by calculating the autophagosome increase rate. The higher the autophagosome increase rate, the better the autophagy ability of the cells.

[0063] The calculation formulas are as follows:

[0064] ATP promotion rate (%) = |(ATP content 样品组 - ATP content 空白对照组 )| / ATP content 空白对照组 × 100%.

[0065] Autophagosome increase rate (%) = |(number of autophagosomes 样品组 - number of autophagosomes 空白对照组 )| / number of autophagosomes 空白对照组 × 100%.

[0066] Table 1 ATP promotion rate and autophagosome increase rate of each group of barrier repair compositions

[0067] Group ATP Increase Rate / % Autophagosome Increase Rate / % Example 1 262.67 403.94 Example 2 243.23 384.86 Example 3 245.14 386.53 Example 4 237.36 368.94 Example 5 238.02 370.01 Example 6 231.32 330.74 Example 7 229.90 343.85 Comparative Example 1 79.23 90.93 Comparative Example 2 83.47 61.05 Comparative Example 3 91.38 62.65 Comparative Example 4 94.94 64.21

[0068] This test directly verifies the energy supply-autophagy clearance mechanism of the composition by detecting the ATP production amount of keratinocytes and the number of autophagosomes, which are the markers of autophagy. By promoting the energy of skin cells, the skin can autonomously complete metabolism and repair the skin lipid barrier.

[0069] From the data of Example 1 and Comparative Examples 1-4 in Table 1, it can be seen that the composition of Example 1 with the compound of four components, namely niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract, has a significant improvement in the ATP promotion rate and autophagosome increase rate of keratinocytes compared with the compositions of Comparative Examples 1-4. This shows that the four components of niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract have a synergistic effect. They promote lipid synthesis by deeply stimulating cell energy and autophagy of damaged mitochondria, thus achieving the effect of barrier repair.

[0070] Combined with the data of Examples 1-7, it can be known that when the weight ratio of niacinamide, wheat germ extract, oat β-glucan and camellia nitidissima extract is (1-2):(0.6-1):(0.8-1):(0.5-1), the composition has a better effect in promoting ATP and autophagosome generation of keratinocytes.

[0071] Application Examples 1-7 and Comparative Application Examples 1-4

[0072] The compositions of Examples 1-7 and Comparative Examples 1-4 were added to the essence at a concentration of 3 wt% respectively to obtain the essences of Application Examples 1-7 and Comparative Application Examples 1-4. The formula is shown in Table 2.

[0073] The preparation methods of the essences of Application Examples 1-7 and Comparative Application Examples 1-4 include the following steps:

[0074] The preparation method of the essence includes the following steps:

[0075] S1. Mix the humectant, thickener and 1 / 2 amount of deionized water, homogenize evenly at 80 °C, then add the preservative and stir evenly to obtain a mixture;

[0076] S2. Wait until the temperature drops to 40 °C, add the components of the composition, essence and the remaining deionized water to the mixture obtained in step S1, stir evenly, and finally add the pH regulator to adjust the pH to 6 to obtain the essence.

[0077] Table 2 Formulas of the essences of Application Examples 1-7 and Comparative Application Examples 1-4

[0078]

[0079] Comparative Application Example 5

[0080] For the essence of Comparative Application Example 5, the composition is not added, and an equal amount of deionized water is used to replace the composition. The preparation method is the same as that of Application Example 1.

[0081] Test Example 2: Efficacy test of the essence

[0082] This test example verifies the improvement effect of the essence liquids of Application Examples 1-7 and Comparative Application Examples 1-5 on facial barrier damage. The experimental data are shown in Table 3.

[0083] Select 96 volunteers aged 18-45 with obvious facial flushing and barrier damage (TEWL value ≥ 20 g / h / m 2 ). One day before arrival, do not apply any skin care products after washing the face. On the day of the test, do not apply any products after washing the test area with clear water. Sit quietly in an air-conditioned room at a temperature of 21 ± 1 °C and a humidity of 50 ± 10% for 20 minutes, and take samples on the forehead with 3M reticulated easy-tear tape; use Visia-CR to take facial photos, and perform image analysis on the red area pictures exported under cross-polarized light to obtain the quantified index a* value of the red area analysis; use a skin transdermal water loss probe TM Hex (Courage+Khazaka) to test the initial facial TEWL value. Randomly divide the subjects into 12 groups, with 8 people in each group. Randomly apply 1 mL of the essence liquids of Application Examples 1-7 and Comparative Application Examples 1-5 to the whole face once in the morning and once in the evening. Take samples of forehead oil again at 7 days (short-term effect) and 28 days (long-term effect), take photos and analyze the a* value and measure the TEWL value.

[0084] As Figure 1 shown in the process, cut the skin keratin sampling patches of the volunteers on days 0, 7, and 28 into 1-2 mm 2 fragments, use 20 times the amount of ethanol containing 0.025% butylated hydroxytoluene to ultrasonically extract the lipids on the patches for 20 minutes (40 kHz, 300 W), after ultrasonic treatment, centrifuge at 3000-5000 rpm for 5-10 minutes, and take the supernatant. Use 1 times the amount of ethyl acetate to perform liquid-liquid extraction on the supernatant to further remove other impurities, and rotate and evaporate the upper layer liquid at 50 °C and 250 rpm to remove ethanol and the remaining ethyl acetate to obtain the sebum extract. The extract is dissolved in a mixture of acetone / methanol / isopropanol (40 / 40 / 20 v / v / v) at a concentration of 5 mg / mL and stored at -80 °C. Select a detection kit with the manufacturer Nanjing Jiancheng and the product number BC5240 to measure the lipid peroxide (LPO) level of each group.

[0085] The calculation formulas are as follows:

[0086] Improvement rate of a* value = |(a* value 使用前 - a* value 使用后 )| / a* value before use × 100%;

[0087] Improvement rate of TEWL value = |(TEWL value 使用后 - TEWL value 使用前 )| / TEWL value 使用前 × 100%;

[0088] LPO inhibition rate = |(LPO 使用前 - LPO 使用后 )| / LPO before use × 100%.

[0089] Table 3 Improvement rates of a* value, TEWL value, and LPO inhibition rate of essence in each group

[0090]

[0091]

[0092] The soothing effect of the application example on facial erythema is represented by the improvement rate of a* value, the repair effect on barrier damage is represented by the improvement rate of TEWL value, and the inhibitory effect on lipid peroxide LPO is represented by the LPO inhibition rate. The higher the values of the improvement rate of a* value and the improvement rate of TEWL value, the better the soothing effect of the application example on facial erythema and the barrier repair effect. And the higher the LPO inhibition rate, the better the scavenging effect of the application example on oxidized lipids and the stronger the corresponding ability to optimize sebum.

[0093] From the data of Application Example 1 and Comparative Application Examples 1 - 4 in Table 3, it can be seen that the soothing effect on facial erythema, the repair effect on barrier damage, and the scavenging effect on oxidized lipids of the composition of Example 1 with the compound of four ingredients of niacinamide, wheat germ extract, oat β - glucan, and camellia chrysantha extract are significantly improved compared with the compositions of Comparative Examples 1 - 4. This shows that the four ingredients of niacinamide, wheat germ extract, oat β - glucan, and camellia chrysantha extract can synergistically play the effects of barrier repair, soothing, and sebum optimization.

[0094] Combined with the data of Application Examples 1 - 7, it can be known that when the weight ratio of niacinamide, wheat germ extract, oat β - glucan, and camellia chrysantha extract is (1 - 2):(0.6 - 1):(0.8 - 1):(0.5 - 1), the effects of barrier repair, soothing, and sebum optimization of the composition are better.

[0095] As Figure 2 shown, the facial flushing of the volunteers who used the essence of Application Example 1 for 28 days was significantly improved, while the improvement of the facial flushing of the volunteers who used the essence of Comparative Application Example 5 for 28 days was worse compared with Application Example 1. This shows that the essence made of the barrier repair composition of the present invention has good effects of repairing the barrier, soothing, and optimizing sebum.

[0096] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A barrier repair composition for activating cell energy, characterized in that: The invention comprises the following components: nicotinamide, wheat germ extract, oat beta-glucan and golden camellia extract, wherein the weight ratio of nicotinamide, wheat germ extract, oat beta-glucan and golden camellia extract is (0.1-5):(0.1-3):(0.1-3):(0.1-5).

2. The barrier repair composition for activating cell energy according to claim 1, characterized in that: The weight ratio of nicotinamide, wheat germ extract, oat beta-glucan and golden camellia extract is (1-3): (0.1-1): (0.5-2): (0.5-2).

3. The barrier repair composition for activating cell energy according to claim 1, characterized in that: The weight ratio of nicotinamide, wheat germ extract, oat beta-glucan and golden camellia extract is (1-2): (0.6-1): (0.8-1): (0.5-1).

4. Use of the barrier repair composition for activating cell energy according to any one of claims 1 to 3 in the preparation of skin care products.

5. Use of the barrier repair composition for activating cell energy according to claim 4 in preparing skin care products, characterized in that: The skin care product is any one of lotion, emulsion, cream, mask, essence or spray, and the added amount of the composition is 0.5%-5% of the total weight of the skin care product.

6. An essence, characterized in that: The invention comprises the following raw materials in weight percentage: 0.5%-5% of the composition according to any one of claims 1 to 3, 0.05%-0.3% of a thickener, 0.5%-10% of a moisturizer, 0.5%-5% of a preservative, 0.01%-0.3% of a pH regulator and 0.01%-1% of an essence, and the balance is deionized water.

7. The essence according to claim 6, characterized in that The raw material is selected from at least one of (a) to (d): (a) the thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol; (b) the moisturizing agent comprises at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, hydrolyzed sodium hyaluronate, 1,2-butylene glycol, glycerol, budding pullulan polysaccharide, and ceramide; (c) the pH adjusting agent comprises at least one of arginine, tromethamine, and EDTA-disodium; (d) The preservative includes at least one of 1,2-propylene glycol, 1,2-hexanediol and p-hydroxyacetophenone.

8. The method for preparing the essence according to claim 7, characterized in that: The following steps are involved: S1. Mix a moisturizer, a thickener and part of deionized water, homogenize at 75-85° C., add a preservative, and stir evenly to obtain a mixture; S2. When the temperature drops to 35-45° C., add the components in the composition, the essence and the remaining deionized water to the mixture obtained in step S1, stir evenly, and finally add a pH adjuster to adjust the pH to obtain the essence.

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