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Compositions comprising strontium and vitamin d and uses thereof

A composition and vitamin technology, applied in the direction of drug combination, bone diseases, heavy metal active ingredients, etc., can solve problems such as increased bleeding and blood coagulation risk, weight gain, etc.

Active Publication Date: 2007-08-15
MOKWALO SPF SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This treatment produces many side effects such as weight gain (fluid infiltration-edema), nausea, vomiting, headache, bleeding from the uterine (cervix) mucous membrane and increased risk of blood clotting

Method used

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  • Compositions comprising strontium and vitamin d and uses thereof
  • Compositions comprising strontium and vitamin d and uses thereof
  • Compositions comprising strontium and vitamin d and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0243] 100% strontium carbonate

[0244] R e =0.59

[0245] 1038g strontium carbonate (7mmol)

Embodiment 2

[0247] 75% strontium carbonate

[0248] 25% strontium chloride

[0249] R e =0.52

[0250] 778.50g strontium carbonate (5.3mmol)

[0251] 469.25g strontium chloride (1.7mmol)

Embodiment 3

[0253] 50% strontium carbonate

[0254] 50% strontium chloride

[0255] R e = 0.46

[0256] 519g strontium carbonate (3.5mmol)

[0257] 938.5g strontium chloride (3.5mmol)

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Abstract

The invention relates to the finding that very favorable pharmacokinetic characters are obtained by combining two strontium salts in one pharmaceutical composition. The present invention relates in one aspect to a pharmaceutical composition comprising at least two strontium salts for use as a medicament, and in particular for the treatment and prevention of bone disorders such as osteoporosis. The composition preferably comprises strontium carbonate and strontium chlorides. Further included may be a vitamin D compound, preferably vitamin D3.

Description

Invention field [0001] The invention relates to a medicinal composition for preparing a medicine for treating cartilage and bone diseases. The composition according to the invention contains at least two strontium salts and may also contain a second active ingredient such as a vitamin D compound. The composition can be used in different types of formulations. Relative to the total amount of strontium salt, the composition contains a large amount of strontium, so it is very useful for the preparation of medicines for treating bone diseases and disorders. Background of the invention [0002] Bone is continuously removed by osteoclasts and replaced by new bone formed by osteoblasts. [0003] This continuous process is highly regulated, that is, the effects of osteoclasts and osteoblasts are linked, so that the total amount of bone does not change, for example, the amount of bone formed is the same as the amount removed. [0004] Osteoblasts synthesize the collag...

Claims

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Application Information

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IPC IPC(8): A61P19/10A61K33/24
Inventor J・N・H・克里斯坦森
Owner MOKWALO SPF SA
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