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Pharmaceutical composition containing PPAR regulator and strontium salt

A technology of modulators and drugs, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2009-09-16
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These reasons should limit the application of PPAR modulators in elderly, postmenopausal women and diabetic patients with osteoporosis

Method used

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  • Pharmaceutical composition containing PPAR regulator and strontium salt
  • Pharmaceutical composition containing PPAR regulator and strontium salt
  • Pharmaceutical composition containing PPAR regulator and strontium salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of granules

[0029]

[0030] Preparation method: crush strontium ranelate, rosiglitazone maleate, aspartame, microcrystalline cellulose, etc. through a 100-mesh drug sieve for later use, then mix the above powders evenly according to the equal-volume addition method, and add 15% Stir the polymicroketone solution to make soft material, pass through a 16-mesh drug sieve to granulate, dry at 60-70°C, sieve with a 16-mesh and 30-mesh drug sieve, measure the content of the main drug, and pack it into a bag.

[0031] How to use: Once a day, one bag at a time.

Embodiment 2

[0033] Preparation of granules

[0034]

[0035] Preparation method: crush strontium ranelate, rosiglitazone maleate, mannitol, aspartame, sweet orange flavor, etc., and pass through a 100-mesh pharmaceutical sieve for later use, then mix the above powders evenly according to the method of equal volume addition, and add 2 Stir an appropriate amount of % hydroxypropyl methylcellulose solution to make soft materials, pass through a 16-mesh drug sieve to granulate, dry at 60-70°C, sieve with a 16-mesh and 30-mesh drug sieve, measure the content of the main ingredient, and pack it into a bag. .

[0036] How to use: Once a day, one bag at a time.

Embodiment 3

[0038] Preparation of granules:

[0039]

[0040] Preparation method: Strontium ranelate, rosiglitazone maleate, vitamin D3, mannitol, aspartame, sweet orange essence, etc. are crushed through a 100-mesh pharmaceutical sieve for later use, and then the above-mentioned powders are mixed evenly according to the method of equal addition , add 2% hydroxypropyl methylcellulose solution and stir to make a soft material, pass through a 16-mesh drug sieve to granulate, after drying, sieve with a 16-mesh and 30-mesh drug sieve, measure the content of the main drug, and pack it into a bag.

[0041] How to use: Once a day, one bag at a time.

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PUM

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Abstract

Composition preparation or pharmaceutical composition related to the invention contains (a) PPAR regulator, (b), strontium salt as active component, which is or is not combined with one or more acceptable excipients in pharmacy, the active component being used at the same, in a separated way or in sequence; the composition is used to improve, prevent or treat osteoporosis caused by prevention or treatment of PPAR regulator or diseases prevented or treated by PPAR regulator and groups with osteoporosis.

Description

technical field [0001] The present invention relates to a combination such as a combined preparation or a pharmaceutical composition, which comprises (a) a PPAR modulator, (b) a strontium salt or one or more pharmaceutically acceptable carriers for simultaneous, separate or Sequential use; and using the combination to improve, prevent or treat diabetes, especially type 2 diabetes and its complications and osteoporosis and its related complications, or caused by multiple effects or side effects of diabetes drugs during the treatment of diabetes Effective combinations and uses for osteoporosis or osteoporosis-related diseases. Background technique [0002] With the improvement of people's living standards, the aging population and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. It has become one of the main diseases affecting human health. Diabetes seriously endangers human health, and its mortality rate is second only to malig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/4439A61K31/593A61K33/14A61P3/10A61P19/10A61K31/191A61K31/381
Inventor 胡湘南吴禄春甘勇军方大树胡思星张检
Owner CHONGQING MEDICAL UNIVERSITY
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