The invention discloses a preparation method and application of
polyethylene glycol functionalized nano
capsule-like gel. The preparation method comprises the following steps: (1) extracting a nano
capsule-like body; (2) preparing
polyethylene glycol functionalized nano
capsule-like gel; and (3) applying the
polyethylene glycol functionalized nano capsule-like gel to mediating photodynamic tooth bleaching. The
polyethylene glycol functionalized nano capsule-like gel is combined with a photodynamic reaction to interfere with an
electron transport chain and promote ROS accumulation, and the nano capsule-like gel with a specific photoreaction oxidation function is constructed, so that the nano capsule-like gel can be used for equivalently bleaching teeth with a traditional bleaching agent, and meanwhile, the activity of the nano capsule-like gel is improved. The sensitive risk to tooth essence and the mechanical
injury risk to enamel and
cementum are remarkably reduced, and the composition can be applied to home care or clinical whitening treatment; and the preparation method is simple, is convenient to use, is mild and non-irritant, is high in
biocompatibility, and has a good market application prospect.