HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material and preparation method and application thereof

A technology of calcium phosphate ceramics and ceramic materials, applied in the field of biomedical materials, can solve problems such as reducing the biological activity of materials, and achieve the effects of ensuring osteoinductive ability, enhancing bone connection and healing functions, and simple preparation process

Inactive Publication Date: 2014-02-19
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN1935270A reports a composite bioceramic material and its preparation technology that uses hydroxyapatite as a matrix and adds diopside and alumina as a toughening and reinforcing phase. Compared with ceramics, it has better fracture toughness, flexural strength and compressive strength, but the addition of calcium phosphate ceramics with doping phase will inevitably reduce the biological activity of the material
Therefore, such biomaterials can only be regarded as bioactive implants, and they still need to be improved to meet the design requirements of a new generation of biomaterials, namely: "meet biological functions of materials, and have active repair, induce tissue Regeneration, repair and reconstruction of damaged tissue" requirements

Method used

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  • HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material and preparation method and application thereof
  • HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material and preparation method and application thereof
  • HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1) Synthesize the matrix phase β-phase tricalcium phosphate (β-TCP) powder by "wet chemical reaction", dry it and crush it by airflow, and screen the dry powder with a diameter of 80-160 μm as the precursor powder for the preparation of porous ceramic embryo body material;

[0057] 2) The reinforcement phase HA micro-nano whiskers were synthesized by the "slurry method", and the Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 Dissolve in deionized water to make a paste; weigh KNO at a molar ratio of 1:1:1 3 、LiNO 3 , KOH and deionized water are mixed and stirred to form a paste as a cosolvent, and then the two paste-like slurries are fully mixed, adjusted to pH=6.5 with hydrochloric acid, coated on the surface of a clean titanium sheet, and placed in a polytetrafluoroethylene In a hydrothermal reaction kettle with ethylene as the substrate, the temperature was raised to 350°C at a rate of 5°C / min, reacted for 10 hours, and naturally cooled to room temperature. The reactio...

Embodiment 2

[0062] Porous calcium phosphate bioactive ceramic products were prepared with biphasic calcium phosphate powder (HA / TCP) as the ceramic matrix phase composition of 95%, and HA micro-nano whiskers with a mass percentage of 5% as the reinforcing phase. The product preparation process and steps are the same as those in Example 1, except that in Step 1, the ceramic powder is synthesized as a dual-phase calcium phosphate material through a "wet chemical reaction". The maximum compressive strength of the ceramic material after the obtained HA micro-nano whiskers are reinforced is 3.35MPa, which is 1.86 times higher than the pure dual-phase calcium phosphate ceramic material 1.80MPa not doped with HA micro-nano whiskers. The maximum compressive strength of porous ceramics is 1.08 MPa higher, because the matrix phase of the biphasic calcium phosphate material with better mechanical properties contributes additional mechanical strength.

Embodiment 3

[0064] Porous calcium phosphate bioactive ceramic products were prepared with pure hydroxyapatite powder (HA) as the ceramic matrix phase composition of 95%, and HA micro-nano whiskers with a mass percentage of 5% as the reinforcing phase. The product preparation process and steps are the same as in Example 1, except that in Step 1, the ceramic powder is synthesized as hydroxyapatite by "wet chemical reaction". The maximum compressive strength of the ceramic material after the obtained HA micro-nano whiskers are reinforced is 4.31MPa, which is 1.96 times higher than the pure dual-phase calcium phosphate ceramic material not doped with HA micro-nano whiskers, and is higher than the reinforced porous ceramics in Example 1. The maximum compressive strength is 2.04MPa higher. This is because in calcium phosphate ceramics, under the same pore structure and the same sintering process conditions, the strength order of different calcium phosphate ceramic materials is: HA>BCP>TCP.

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Abstract

The invention discloses a HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material which is characterized by using calcium phosphate as a material matrix phase and mixing hydroxyapatite (HA) micro-nano whisker as a reinforcing phase for improving material mechanical properties. The preparation process is as follows: respectively synthesizing a calcium phosphate matrix phase precursor powder material and a hydroxyapatite micro-nano whisker reinforced phase material; then doping 3 ~ 10% of the hydroxyapatite micro-nano whisker to composite into ceramic body powder for preparing a porous ceramic body, finally calcining by a muffle furnace to obtain the reinforced porous bioactive calcium phosphate ceramic. Biological materials are a calcium phosphate component and a hydroxyapatite component which have similar chemical compositions with natural bones, the ceramic has excellent bioactivity due to a finely specially made porous structure, the mechanical properties of the ceramic are reinforced by doping of the micro-nano hydroxyapatite whisker, and the porous ceramic used as a bone repair material has the excellent bioactivity and good mechanical properties and has a wide application prospect in clinical departments of orthopedics.

Description

technical field [0001] The invention relates to a hydroxyapatite (HA) micronano whisker-reinforced calcium phosphate ceramic material and a preparation method and application thereof, belonging to the field of biomedical materials. Background technique [0002] Biomaterials for load-bearing bone repair require materials with both good mechanical properties and biological activity. Porous calcium phosphate ceramics (Calcium Phosphate Bioceramics, CaP), because its chemical composition is similar to human bone tissue, and has a porous structure, it has a variety of excellent biological properties such as good osteoconduction, osteoinduction, and degradable absorption. In order to meet the needs of new bone tissue ingrowth and increase the speed of bone fusion, bone repair materials must have an interconnected three-dimensional porous structure, the ideal macropore size is 100-500 μm, and the porosity should be greater than 60%. However, due to the existence of pore structure ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/10C04B35/81C04B35/447C04B35/622
Inventor 周长春叶兴江樊渝江肖占文陈宏杰张兴栋
Owner SICHUAN UNIV
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