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Temperature-sensitive organic-inorganic composite hydrogel material and preparation method thereof

An inorganic composite and hydrogel technology, applied in the direction of inorganic raw material artificial filament, pharmaceutical formulations, prostheses, etc., can solve the problems of dangerous repair materials, limited osteogenic efficiency, high price, etc., and improve osteogenic biological activity. , Improve clinical operability, controllable effect of preparation process

Inactive Publication Date: 2018-06-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The artificial bone substitute materials currently used clinically include allograft bone (decalcified freeze-dried bone), xenograft bone (Bio-Oss powder repair material of deproteinized calf bone), hydroxyapatite (HA) and Bone repair materials with calcium phosphate (β-TCP) as the main component, such as Straumann BoneCeramic, etc., are almost all imported and expensive, and the repair materials from biological sources are also potentially dangerous
In addition, clinical studies have shown that these materials have relatively limited osteogenic performance, and the scope of clinical application is narrow, and most of the products are powders, which are inconvenient for clinical operation and difficult to shape, and are helpless for vertical and slightly larger bone loss.

Method used

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  • Temperature-sensitive organic-inorganic composite hydrogel material and preparation method thereof
  • Temperature-sensitive organic-inorganic composite hydrogel material and preparation method thereof
  • Temperature-sensitive organic-inorganic composite hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Dissolve 5g of gelatin in 40ml of deionized water, add 1.67g of α-bromoisobutyric acid, add 2.3g of 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide and N -Hydroxysuccinimide 0.55g at 40 o C reacted for 24 hours, and purified by ethanol precipitation to obtain brominated gelatin; dissolve 2 g of brominated gelatin in 20 ml of dimethyl sulfoxide, add 10 g of N-isopropylacrylamide, add 1, 1, 4, 7, 7 methyl di Ethylenetriamine 200μl, add 0.1g cuprous bromide after purging nitrogen to deoxygenate, at 30 o C was reacted for 1 hour; the reaction mixture was poured into deionized water to terminate the reaction, and after purification with aluminum oxide chromatographic column to remove cuprous bromide, deionized water was dialyzed to remove unreacted N-isopropylacrylamide and 1, 1,4,7,7-methyldiethylenetriamine, poly(N-isopropylacrylamide)-grafted gelatin (Gel-g-PNIPAAm-1) was obtained after lyophilization. The critical solution temperature (LCST) of its aqueous solution i...

Embodiment 2

[0029] (1) The preparation of Gel-g-PNIPAAm-1 is the same as step (1) of Example 1.

[0030] (2) After mixing triethyl phosphate, ethanol and water at a molar ratio of 1:3:3, add 0.5% ammonia water as a catalyst to adjust the pH of the system to 9, at 80 o Hydrolyze at C for 24 hours to obtain fully hydrolyzed organic phosphoric acid mixture A; dissolve calcium nitrate tetrahydrate and magnesium nitrate hexahydrate in absolute ethanol at a molar ratio of 95:5 to prepare 3mol / L nitrate Alcoholic solution B; according to the calcium-phosphorus molar ratio of 1.6, the nitrate alcohol solution B is added dropwise in the triethyl phosphate hydrolysis solution A, at 4 o C was stirred and mixed for 2 hours to obtain primary sol solution C; the primary sol was placed at -20 o After C aging for 7 days, the spinning solution was prepared according to the mass ratio of sol:water = 5:1, and polyvinylpyrrolidone (Mn=1,300,000) was added as a spinning aid at a concentration of 4wt.%. After...

Embodiment example 3

[0034] (1) Dissolve 5g of gelatin in 40ml of deionized water, add 3.34g of α-bromoisobutyric acid, add 4.6g of 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide and N -Hydroxysuccinimide 1.1g at 40 o C reacted for 24 hours, and purified by ethanol precipitation to obtain brominated gelatin; dissolve 2 g of brominated gelatin in 20 ml of dimethyl sulfoxide, add 20 g of N-isopropylacrylamide, add 1, 1, 4, 7, 7 methyl di Ethylenetriamine 400μl, add 0.2g cuprous bromide after purging nitrogen to remove oxygen, at 30 o C was reacted for 1 hour; the reaction mixture was poured into deionized water to terminate the reaction, and after purification with aluminum oxide chromatographic column to remove cuprous bromide, deionized water was dialyzed to remove unreacted N-isopropylacrylamide and 1, 1,4,7,7-methyldiethylenetriamine, poly(N-isopropylacrylamide)-grafted gelatin (Gel-g-PNIPAAm-2) was obtained after lyophilization. The critical solution temperature (LCST) of its aqueous solution ...

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Abstract

The invention provides a temperature-sensitive organic-inorganic composite hydrogel material and a preparation method thereof. The material has good plasticity, can easily realize filling of a defected part and shows ossification activity. The temperature-sensitive organic-inorganic composite hydrogel material is prepared by compounding synthesized poly(N-isopropylacrylamide)-grafted gelatin withion-doped calcium phosphate ceramic nanofibers. The plasticity of the material is realized in virtue of the characteristic of negative temperature sensitivity of poly(N-isopropylacrylamide) and the capability of an aqueous solution of the poly(N-isopropylacrylamide)-grafted gelatin in forming a hydrogel under the condition of body temperature. The composite hydrogel material may appear to be liquid capable of realizing filling through injection or to be paste easy to operate in the case of different compounding ratios of the hydrogel and the calcium phosphate ceramic nanofibers, can realize effective filling of bone defects of irregular shapes, better meets the needs of clinical treatment of bone defects and accords with the clinical characteristics of bone augmentation repair.

Description

technical field [0001] The invention belongs to the field of biocomposite materials, and in particular relates to a temperature-sensitive organic-inorganic composite hydrogel material and a preparation method, which are suitable for guided regeneration and repair of bone defects. Background technique [0002] The incidence of bone tissue defects caused by trauma, inflammation, tumors and congenital factors is relatively high, such as alveolar bone resorption and tooth loss caused by periodontal disease, a common oral disease, and jaw trauma and bone defects caused by traffic accidents , and developmental diseases such as alveolar ridge cleft associated with congenital cleft lip and palate, more than 3 million people a year. However, large-scale bone defects usually cannot heal on their own. The commonly used bone augmentation materials in clinical practice are mainly autologous bone tissue graft materials and commercial artificial bone substitute materials. The artificial b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F289/00C08F220/54D01F9/08D01F8/18C08L51/00C08K7/08A61L27/16A61L27/12A61L27/02A61L27/52A61L27/54
CPCA61L27/16A61L27/025A61L27/12A61L27/52A61L27/54A61L2300/102A61L2300/412A61L2400/06C08F289/00C08J3/075C08J2351/00C08K7/08C08K2201/011D01F8/18D01F9/08C08F220/54C08L51/00
Inventor 蔡晴蒙俊权杨汇川任志伟艾淼
Owner BEIJING UNIV OF CHEM TECH
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