Magnetic nanoparticle/calcium phosphate ceramic composite porous material and preparation method thereof

A technology of magnetic nanoparticles and calcium phosphate ceramics, which is applied in the field of biomedical materials, can solve the problems of difficult to accurately control the content of magnetic nanoparticles, uneven distribution, poor controllability, etc., and achieve good bone repair and bone induction ability, Beneficial for industrial production and good biocompatibility

Active Publication Date: 2012-01-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The electrostatic self-assembly process involved in the method is greatly affected by the surface and interface characteristics of porous hydroxyapatite and magnetic nanoparticles, and the surface and interface of porous hydroxyapatite are very uneven, so the controllability of the method Poor, the magnetic nanoparticles in the material prepared by thi...

Method used

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  • Magnetic nanoparticle/calcium phosphate ceramic composite porous material and preparation method thereof
  • Magnetic nanoparticle/calcium phosphate ceramic composite porous material and preparation method thereof
  • Magnetic nanoparticle/calcium phosphate ceramic composite porous material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Fe 3 o 4 Preparation of ferrofluid

[0037] Hydrophobic superparamagnetic Fe with an average particle size of 10 nm coated with oleic acid prepared by pyrolysis 3 o 4 Nanoparticles dispersed in n-hexane to make Fe 3 o 4 Fe at a concentration of 10 mg / ml in nanoparticles 3 o 4 Ferrofluid;

[0038] (2) Preparation of composite powder

[0039] Take 10g of hydroxyapatite airflow powder, pre-sinter under normal pressure and 800°C for 8 hours, cool to room temperature, mix with 7ml of polyvinyl alcohol aqueous solution with a concentration of 50mg / ml and 0.1g of triethylene glycol and 50ml of the step (1) Prepared Fe 3 o 4 Grind and mix the magnetic fluid, then put it into a vacuum drying oven and dry it under vacuum for 24 hours at room temperature, take it out after drying and continue grinding until the agglomerated powder is completely broken to obtain a uniformly mixed composite powder;

[0040] (3) Preparation of green body

[0041] Take 6g of stearic ac...

Embodiment 2

[0059] (1) Fe 3 o 4 Preparation of ferrofluid

[0060] Hydrophobic superparamagnetic Fe with an average particle size of 8 nm coated with oleic acid prepared by pyrolysis 3 o 4 Nanoparticles dispersed in n-hexane to make Fe 3 o 4 Fe at a concentration of 10 mg / ml in nanoparticles 3 o 4 Ferrofluid;

[0061] (2) Preparation of composite powder

[0062] Take 10g of hydroxyapatite airflow powder, pre-sinter at normal pressure and 800°C for 8 hours, cool to room temperature and mix with 7ml of polyvinyl alcohol aqueous solution with a concentration of 50mg / ml and 0.1g of triethylene glycol and 20ml of step (1) Prepared Fe 3 o 4 Grind and mix the magnetic fluid, then put it into a vacuum drying oven and dry it under vacuum for 24 hours at room temperature, take it out after drying and continue grinding until the agglomerated powder is completely broken to obtain a uniformly mixed composite powder;

[0063] (3) Preparation of green body

[0064] Take 6g of stearic acid, a...

Embodiment 3

[0069] (1) Fe 3 o 4 Preparation of ferrofluid

[0070] Hydrophobic superparamagnetic Fe with an average particle size of 10 nm coated with oleic acid prepared by pyrolysis 3 o 4 Nanoparticles dispersed in n-hexane to make Fe 3 o 4 Fe at a concentration of 10 mg / ml in nanoparticles 3 o 4 Ferrofluid;

[0071] (2) Preparation of composite powder

[0072] Take 10g of hydroxyapatite airflow powder, pre-sinter at normal pressure and 800°C for 8 hours, cool to room temperature, mix with 7ml of polyvinyl alcohol aqueous solution with a concentration of 50mg / ml and 10ml of Fe prepared in step (1) 3 o 4 Grind and mix the magnetic fluid, then put it into a vacuum drying oven and dry it under vacuum for 24 hours at room temperature, take it out after drying and continue grinding until the agglomerated powder is completely broken to obtain a uniformly mixed composite powder;

[0073] (3) Preparation of green body

[0074] Take 4.5g of pore-forming agent naphthalene with a partic...

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Abstract

The invention relates to a magnetic nanoparticle/calcium phosphate ceramic composite porous material. Calcium phosphate ceramic serves as a matrix; the calcium phosphate ceramic matrix has a porous structure; superparamagnetic Fe3O4 magnetic nanoparticles are distributed on the calcium phosphate ceramic matrix uniformly; the superparamagnetic Fe3O4 magnetic nanoparticles are hydrophobic Fe3O4 or hydrophilic Fe3O4; the average particle size of the superparamagnetic Fe3O4 magnetic nanoparticles is 4 to 20 nm; and the content of the superparamagnetic Fe3O4 magnetic nanoparticles is 1 to 10 percent of the mass of the calcium phosphate ceramic matrix. A preparation method for the magnetic nanoparticle/calcium phosphate ceramic composite porous material comprises the following steps of: (1) preparing Fe3O4 magnetic fluid; (2) preparing composite powder; (3) preparing green bodies; and (4) performing vacuum sintering, namely calcining the green bodies subjected to compression moulding at thetemperature of between 300 and 400 DEG C for 20 to 40 minutes by using a vacuum sintering furnace, heating to 1,000 to 1,200 DEG C, calcining for 1 to 2 hours, and cooling to room temperature along with the furnace to obtain the magnetic nanoparticle/calcium phosphate ceramic composite porous material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a porous magnetic ceramic composite material and a preparation method thereof. Background technique [0002] Porous magnetic ceramic composite materials are a new type of composite materials, which have broad application prospects in the treatment of bone defects and bone tumors and other orthopedic diseases. ZL200810041740.4 Chinese patent discloses a porous magnetic hydroxyapatite material and its preparation method and application. The porous magnetic hydroxyapatite material is composed of magnetic nanoparticles and ordered porous hydroxyapatite through electrostatic self-assembly and capillary Assembled under the action of force, the magnetic nanoparticles are SiO 2 Composite nanoparticles with wrapped core-shell structure, the core layer of composite nanoparticles is Fe 3 o 4 , γ-Fe 2 o 3 , Mn-Zn doped ferrite or one of other ferrites. The electrostatic self-assembly ...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622C04B38/00
Inventor 吴尧曾晓波蓝芳顾忠伟
Owner SICHUAN UNIV
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