36 results about "Fe3o4 magnetic nanoparticles" patented technology

The invention belongs to the technical field of environmental protection, and provides a preparation method of an imine-modified functionalized mesoporous magnetic silicon dioxide nano material. The method comprises the following steps: synthesizing Fe3O4 magnetic nanoparticles in a Fe < 2 + > / Fe < 3 + > alkaline hydrolysis system through a coprecipitation method; then coating the magnetic nanoparticles with an amorphous silicon dioxide layer by taking TEOS (tetraethoxysilane) as a silicon source by adopting a sol-gel method, so as to prepare magnetic silicon coated nanoparticles; the prepared nano-particles are subjected to secondary silicon coating guided by a cetyl trimethyl ammonium bromide (CTAB) mesoporous template agent, and mesoporous magnetic silicon nano-particles are formed after calcination; and finally, carrying out surface amination modification on the mesoporous magnetic silicon nano-particles by utilizing an amino silane coupling agent, and then carrying out condensation reaction on the mesoporous magnetic silicon nano-particles and various aldehyde derivatives to construct imine bonds, so as to obtain the imine-modified functionalized mesoporous magnetic silicon dioxide nano-material. The imine-modified functionalized mesoporous magnetic silicon dioxide nano-material formed by the invention has the characteristics of efficient adsorption, rapid magnetic recovery and excellent environmental stability, and can effectively remove polystyrene micro-plastics and organic pollutants in a water body.

The invention discloses a preparation method of Fe3O4 magnetic nanoparticles rich in carboxyl groups on the surface, which comprises the following steps: modifying Fe3O4 nanoparticles by using polyethylene glycol and silicon dioxide to enhance the dispersity and biocompatibility of the magnetic nanoparticles, modifying the surfaces of PEG-Fe3O4 coated SiO2 nanoparticles by using a silane coupling agent containing silane groups and unsaturated double bonds to obtain the magnetic nanoparticles rich in carboxyl groups on the surface, and modifying the magnetic nanoparticles rich in carboxyl groups on the surface by using a silane coupling agent containing silane groups and unsaturated double bonds to obtain the magnetic nanoparticles rich in carboxyl groups on the surface. Then octavinyl-POSS and double bonds on the surfaces of the nano particles are subjected to click modification to form an octahedral cage, 4-mercaptobenzoic acid and double bonds are further subjected to click modification, the surfaces of the nano particles are rich in carboxyl, and a polymer brush rich in carboxyl is constructed. Compared with a conventional streptavidin coupling method, a high-density polymer chain provides a large number of carboxyl active binding sites, so that the streptavidin coupling amount is increased, the antibody coupling rate is increased, and a solution is provided for applications such as high-sensitivity biological detection, efficient targeted drug delivery and stable immunoassay.

The invention discloses preparation of immobilized alpha-glucosidase based on a magnetic metal organic framework (MOF) and application of the immobilized alpha-glucosidase in screening of natural enzyme inhibitors. According to the method, ZIF-90 is grafted on the surfaces of Fe3O4 magnetic nanoparticles modified by codeposition of polydopamine and polyethyleneimine, and alpha-glucosidase is synchronously encapsulated in situ in the growth process of the ZIF-90, so that the magnetic MOF immobilized alpha-glucosidase is successfully constructed. On the application level, an in-vitro enzyme inhibition activity evaluation system is constructed, multiple traditional Chinese medicine extracts are selected as research objects, and by means of the characteristic that the magnetic MOF immobilized alpha-glucosidase is easily separated from a reaction system, accurate screening of natural inhibitors or active small molecules is rapidly and efficiently achieved; and a novel screening method is provided for research and development of candidate drugs for diabetes mellitus. The method comprises the following steps: 1, preparing the magnetic MOF immobilized alpha-glucosidase and evaluating the performance of the magnetic MOF immobilized alpha-glucosidase; and 2, the prepared immobilized alpha-glucosidase is used for screening a natural enzyme inhibitor. Based on a magnetic MOF immobilized enzyme technology, the method provided by the invention has the characteristics of rapidness, high efficiency, accuracy, easiness in separation from a reaction system and reutilization of a target receptor alpha-glucosidase, is suitable for screening of alpha-glucosidase inhibitors in complex systems such as traditional Chinese medicines, and has a wide application prospect.

The present application belongs to the technical field of biological medicine, and particularly relates to a thiol phenylboronic acid mediated nano-enzyme immunochromatography reagent and application thereof. The present application utilizes the broad-spectrum binding ability of MPBA to the glycosylated molecules on the surface of pathogens, and combines the colorimetric catalytic double enhancement effect of the virus-like biomimetic magnetic nano-enzyme (FeAu@AuIr), to improve the detection sensitivity. The probe takes Fe3O4 magnetic nanoparticles as the core, and sequentially loads large-diameter gold nanoparticles (Au) and gold-iridium alloy (AuIr) with high catalytic activity, to enhance the pathogen capture capacity and signal amplification effect. Combined with the antibody modified immunochromatography strip, Streptococcus pneumoniae, Pseudomonas aeruginosa and SARS-CoV-2 can be simultaneously detected, and the detection sensitivity is greatly improved. Through verification of 170 clinical samples, the present application has good application prospect in on-site rapid detection, and provides an efficient and low-cost solution for precise screening of respiratory tract infectious pathogens.

The invention provides acellular matrix hydrogel loaded with animal acellular omentum particles as well as a preparation method and application of the acellular matrix hydrogel loaded with the animal acellular omentum particles, and relates to the technical field of tissue engineering and regenerative medicine. Comprising a decellularization treatment agent, a decellularization matrix, functional particles, an enzymolysis agent, a cross-linking stabilizer, a functional additive and a solvent, the functional additive is prepared from PDA coated Fe3O4 magnetic nano particles, phosphorylated polyglycerol sebacate and liposome coated silver nano particles. The PDA-Fe3O4 magnetic nanoparticles of the functional additive generate mechanical signals under the action of an external magnetic field, a Piezo1 mechanical gating cation channel is activated to promote calcium ion internal flow, and the autonomous mineralization ability of phosphorylated polyglycerol sebacate is combined, so that the activity of the bone differentiation marker alkaline phosphatase is effectively improved, and the bone differentiation marker alkaline phosphatase is prepared. The combination of the PDA coated Fe3O4 magnetic nanoparticles and the phosphorylated polyglycerol sebacate integrates a magnetic response mineralization system.

The invention discloses application of iron oxide nanoparticles in target treatment of schistosome eggs, and relates to the cross technical field of nano material target delivery and disease prevention and control. On the basis of paramagnetism, a microtubule structure and surface electrical characteristics of schistosoma japonicum egg shells, electrically neutral Fe3O4 magnetic nanoparticles with the particle size of 8-15 nm or electropositive Fe3O4-NH2 magnetic nanoparticles with the surface modified by amino groups are innovatively adopted, efficient egg penetration is achieved through magnetic targeted enrichment and physical-static synergistic effect, and in-vivo and in-vitro experiments prove that the effect of effectively penetrating through the eggs is achieved. The Fe3O4 and Fe3O4-NH2 nanoparticles have obvious worm egg targeting capability, and the penetrating efficiency of the Fe3O4 and Fe3O4-NH2 nanoparticles on worm eggs exceeds 38%, so that an important experimental basis is provided for subsequent development of a nano-drug delivery system for preventing and treating schistosomiasis.

This invention relates to a self-triggered demulsification Pickering emulsion cascade catalytic system, its preparation method, and its application. The preparation method includes: preparing Fe3O4 magnetic nanoparticles by co-precipitation; coating their surface with a SiO2 shell using a modified Stöber method to obtain Fe3O4@SiO2 core-shell nanoparticles; simultaneously grafting a triamine silane coupling agent and octyltrimethoxysilane onto the Fe3O4@SiO2 surface using a one-pot method to obtain magnetic amphiphilic nanoparticles; dividing the magnetic amphiphilic nanoparticles into two batches, and immobilizing glucose oxidase and Candida antarcticis lipase B respectively via EDC / NHS-mediated amide coupling reaction to obtain nanoparticle catalysts; using the nanoparticle catalysts as solid emulsifiers in Pickering emulsions to construct an oil-water two-phase cascade catalytic system, realizing a cascade catalytic reaction of glucose oxidation – peracidification – olefin epoxidation; utilizing the accumulation of gluconic acid during the reaction to lower the pH, triggering emulsion demulsification, achieving product separation and magnetic recovery of the nanoparticle catalysts.

The application discloses a kind of magnetic nanocomposite and its application in dye wastewater treatment, belong to water treatment functional material technical field.The magnetic nanocomposite with Fe3O4 Magnetic Nanoparticle as core, successively coats silica layer, graphene nanosheet layer and chitosan crosslinking layer, through the synergistic effect of chitosan liquid ultrasonic modification and graphene nanosheet surface modification, realize efficient adsorption and magnetic separation recovery to dye molecule.The preparation process of the application is mild controllable, environment-friendly, cost moderate, has wide application prospect in printing and dyeing wastewater advanced treatment, industrial dye pollution control field, graphene nanosheet greatly promotes specific surface area and adsorption site, chitosan provides a large number of amino / hydroxyl active groups, three synergies realize high adsorption capacity.Graphene nanosheet is reduced by liquid phase ultrasonic stripping, avoids stacking;Chitosan is modified by ultrasonic and TiO2 is scattered, combination is more firm, material structure is stable, not easy to lose, acid and alkali resistant.

The preparation method comprises the following steps: (1) dispersing a certain amount of ferric salt and ferrous salt in a solvent A under the protection of an inert atmosphere, dropwise adding ammonia water, and washing and drying by using magnetic separation after the reaction is finished, so as to obtain Fe3O4 magnetic nanoparticles; and (2) uniformly dispersing a certain amount of zinc salt and the Fe3O4 magnetic nanoparticles prepared in the step (1) into a solvent B, dropwise adding a solution B containing a certain amount of sodium hydroxide, and reacting at a certain temperature. And after the reaction is finished, washing by using magnetic separation, and drying, so as to obtain the Zn and Fe bimetallic synergistic catalyst Fe3O4 (at) ZnO with Lewis acid site for chemical recovery of polyester. The invention also comprises application of the catalyst for chemical recovery of polyester prepared by the method in catalysis of chemical recovery of polyester. The obtained catalyst has good polyester recovery performance and stability, waste plastics can be depolymerized to prepare regenerated plastics, and high-value resource utilization is achieved.

The present invention discloses a ratiometric bipolar electrode electrochemiluminescence biosensor based on quasi-homogeneous reaction and its application. 2+ Using the DNA / TPrA system as a dual-anode signal source, a novel ratiometric bipolar electrode electrochemiluminescence biosensor for miRNA detection and analysis was constructed. By combining the ligase chain reaction with CRISPR / Cas technology and integrating gold nanoparticle-modified Fe3O4 magnetic nanoparticles enriched with ferrocene nucleic acid signal probes (DNA-Fc / Au@Fe3O4 NPs) as a multifunctional reaction interface, the sensor effectively modulates the signal changes of the two ECL reaction systems. Ultrasensitive detection of miRNA-222 is achieved through the ratio of the two signals. The constructed sensor exhibits exceptional performance for miRNA-222 detection and is expected to be applied as a novel detection method in early clinical diagnosis and single-cell analysis.

The invention relates to a bone repair micro-nano robot with magnetic control targeting performance as well as a preparation method and application thereof, and belongs to the technical field of biological materials. In the micro-nano robot, a biodegradable polymer and Fe3O4 magnetic nanoparticles are compounded into magnetic particles, and CeO2 nanoparticles are coated on the surfaces of the magnetic particles through an electrostatic adsorption effect. The method is easy to operate and high in preparation efficiency, the obtained micro-nano robot is uniform in particle size, targeted driving of a single micro-nano robot and a group micro-nano robot can be achieved in a magnetic field, toxic and side effects on organisms are low, bone marrow mesenchymal stem cells can be promoted to be differentiated into osteoblasts, and active oxygen in the environment can be removed.

The application discloses a preparation method of Fe3O4@CD-MOF and porous carbon derived therefrom, and is prepared through the following steps: step one, condensation of carboxyl-functionalized Fe3O4 magnetic nanoparticles and amino-modified cyclodextrin to obtain Fe3O4-CD; step two, mixing of potassium hydroxide, cyclodextrin, Fe3O4-CD and an alcohol-water mixed solution; step three, microwave treatment of the mixed solution, mechanical stirring in an alcohol solvent or in an alcohol gas atmosphere, separation, cleaning, vacuum drying, and obtaining of the Fe3O4@CD-MOF material with a core-shell structure. The Fe3O4@CD-MOF material with a core-shell structure is formed by means of microwave through layer-by-layer wrapping and assembly, the preparation method is simple in process, mild in reaction condition, low in cost, friendly to the environment, and free of toxic and harmful substances, and the Fe3O4@CD-MOF material can be recycled and reused through an external magnetic field.

The invention belongs to the technical field of adsorbent materials, and particularly relates to a magnetic transition metal sulfide adsorption material and a preparation method and application thereof. The preparation method comprises the following steps: by taking Mo-MOF as a precursor, calcining a sulfur source and the Mo-MOF at 1000-1100 DEG C under a protective atmosphere, carbonizing a ligand in the Mo-MOF to form a porous carbon matrix, performing a vulcanization reaction on the sulfur source and Mo < 3 + > to form MoS2 particles, and embedding the MoS2 particles into the porous carbon matrix to obtain MoS2 / C; a chemical coprecipitation method is adopted, Fe3O4 magnetic nanoparticles are loaded on the surface of MoS2 / C, and the magnetic transition metal sulfide adsorption material is obtained. The prepared magnetic transition metal sulfide adsorption material can efficiently and selectively adsorb and reduce Au < 3 + > in a water body, rapid separation can be carried out through magnetism, and resource recycling of gold is achieved.

The present application relates to the technical field of nanocapsules for medical preparations, and particularly relates to dTRIM24 biocompatibility-based anti-atherosclerotic nanoparticles composed of nanoparticles and M1 macrophage membrane vesicles. By using a microfluidic photoporation chip, the nanoparticles are encapsulated by the M1 macrophage membrane vesicles. The nanoparticles are obtained by combining dTRIM24 and Fe3O4 magnetic nanoparticles. The biomimetic nanoparticles of the present application reasonably solve the problems of poor specificity and low efficiency, and have improved anti-atherosclerotic plaque-targeting and biological homology.

The invention discloses a magnetic heterojunction tunable two-dimensional friction material as well as preparation and application thereof. The method comprises the following steps: dissolving a polymer in deionized water, stirring until the polymer is completely dissolved, adding Fe3O4 / MXene coated BN, and stirring until the Fe3O4 / MXene coated BN is uniformly dispersed to obtain a mixed solution; slowly adding the cross-linking agent solution into the mixed solution while stirring to form a uniform polymer coating, and washing the polymer coating with deionized water; the problem that the friction coefficient cannot be reversibly regulated in real time in the prior art is solved. An MXene-coated BN heterojunction two-dimensional material is constructed, Fe3O4 magnetic nanoparticles are introduced to obtain a magnetic heterojunction two-dimensional material, the magnetic heterojunction two-dimensional material is added into a polymer coating, and the deflection angle of the Fe3O4 / MXene-coated BN heterojunction two-dimensional material in the polymer coating is changed through the interaction of an external magnetic field and the Fe3O4 magnetic nanoparticles, so that the friction performance of the material is dynamically regulated and controlled.

The invention relates to the field of medical micro-nano robots, in particular to a dendritic cell micro-nano robot for treating colorectal cancer and a preparation method of the dendritic cell micro-nano robot. The cancer cell membrane coating nanocapsule comprises a PLGA (poly (lactic-co-glycolic acid)) drug-loaded magnetic microsphere and a cancer cell membrane coated on the PLGA drug-loaded magnetic microsphere; the preparation method comprises the following steps: step one, synthesizing PLGA (poly (lactic-co-glycolic acid)) drug-loaded magnetic microspheres loaded with hydrophobic Fe3O4 magnetic nanoparticles and drugs; 2, fusing a cancer cell membrane to the surface of the PLGA drug-loaded magnetic microsphere to form a cancer cell membrane coating nanocapsule; 3, enabling the dendritic cells to phagocytize the cancer cell membrane coating nanocapsule to form a micro-nano robot; according to the dendritic cell micro-nano robot, the micro-nano technology and immunotherapy are combined, and the immune activation function of the dendritic cells can be enhanced through precise targeting and delivery strategies, so that the cancer immunotherapy effect is improved.

The invention provides a magnetic adsorption nanometer material and a preparation method and application thereof, and belongs to the technical field of nanometer materials, the preparation method comprises the following steps: uniformly dispersing functionalized Fe3O4 nanometer magnetic particles in a solvent, adding a mixture of tetrabutyl titanate and acetylacetone, and reacting to obtain titanium modified Fe3O4 nanometer composite microspheres; then adding the nano-particles into a carbon nano-tube dispersion liquid, and carrying out ultrasonic stirring and solid-liquid separation to finally obtain a magnetic adsorption nano-material; wherein the functionalized Fe3O4 magnetic nanoparticles are prepared by carrying out surface treatment on magnetic Fe3O4 nanoparticles by using tetraethoxysilane and then grafting amino and carboxyl active groups. The preparation method provided by the invention is simple to operate, green and environment-friendly, and the prepared magnetic adsorption nano material can effectively adsorb impurities in a detection matrix, has relatively high reusability and durability, and has very important significance for solving the technical bottleneck problem of detection of animal-derived Chinese patent medicine prohibited drug residues.

The invention discloses a treatment method of paint-containing high-COD (Chemical Oxygen Demand) waste liquid in the automobile manufacturing industry, and belongs to the technical field of automobile manufacturing wastewater treatment. The method comprises the following steps: firstly, loading Fe < 2 + > and Cu < 2 + > through Fe3O4 magnetic nanoparticles, and coating with a KH-550 ethanol solution to form a siloxane layer, so as to prepare a bimetallic magnetic Fenton reagent; the reagent is added into the waste liquid, the pH is adjusted to 2.5-4.5 with an H2SO4 solution, and then ozone is introduced for pre-oxidation; then adding rare earth doped amphoteric ZIF-8, adjusting the pH value to 6.5-8.5 by using an alkaline solution, stirring to form a composite floc, and standing; and recovering flocs through magnetic separation, collecting supernate, crushing residual flocs through ultrasonic treatment, and then introducing the crushed flocs into a gradient aperture ceramic membrane assembly loaded with a MnO2-gamma-FeOOH gradient catalyst layer for filtration. Through the steps of bi-metal synergistic catalysis enhanced oxidation, ZIF-8 adsorption and the like, efficient removal of refractory pollutants is achieved, the sludge yield is greatly reduced, membrane operation is stable, a core material can be recycled, and the method is suitable for deep treatment of paint-containing high-COD waste liquid in the automobile manufacturing spraying process.

The application relates to a preparation process of an antibacterial magnetic health-care fabric. The preparation process of the antibacterial magnetic health-care fabric comprises the following steps: Fe3O4 magnetic nanoparticle preparation; Fe3O4@SiO2@Ag magnetic nanoparticle preparation; magnetic fiber preparation: ultrasonic dispersion of the magnetic particles in bamboo fibers for a certain time, spraying of the spinning solution out of a spinning hole by using a wet spinning machine, direct entering of the spinning solution into a prepared coagulation bath to react and form a fiber bundle, and then fiber bundle stretching and winding by using front and rear stretching rollers. The main process of the spinning process is: beating - carding - drawing - roving - spinning - bobbin winding - doubling - doubling twisting. The magnetic fiber and the negative ion viscose fiber are used to develop single-layer and double-layer fabrics based on 2 / 2 twill as a basic structure, and the warp and weft yarns of each fabric are the same. The application has the advantages of green health, antibacterial, health care and the like.

The invention belongs to the technical field of high polymer materials, and relates to a magnetic cation covalent organic framework material as well as a preparation method and application thereof. The invention provides a magnetic cation covalent organic framework material. The magnetic cation covalent organic framework material is characterized in that the surfaces of Fe3O4 magnetic nanoparticles are coated with a polyamino compound and a polyaldehyde compound through a Schiff base reaction to form a shell layer; the polyamino compound is 3, 8-diamino-5-methyl-6-phenyl phenanthridine-5-onium bromide, and the polyaldehyde compound is 2, 2 '-bipyridine-5, 5'-diformaldehyde. According to the property of the aromatic amino acid oxidation product, an organic framework with Bpy and DB as ligands is correspondingly designed, and the prepared magnetic cation covalent organic framework material is suitable for enrichment of the aromatic amino acid oxidation product and has high sensitivity and selectivity when being applied to quantitative analysis of the aromatic amino acid oxidation product in food.

The invention belongs to the technical field of high-purity extraction of effective components of traditional Chinese medicines, and discloses a method for directionally extracting loganin from dogwood through photocatalysis-molecular recognition coupling. The method comprises the following steps: (1) modifying Fe3O4 magnetic nanoparticles by adopting a loganin aptamer to prepare aptamer modified magnetic nanoparticles; (2) adding a mixture of dogwood powder and water into a reaction kettle in which an anatase phase TiO2 nanotube array is arranged, stirring for photocatalytic wall breaking in an inert gas atmosphere and under the condition of an ultraviolet light source, adding the aptamer-modified magnetic nanoparticles into the reaction kettle after 30-45 minutes, continuing stirring for reaction for 1-2.5 hours, collecting the aptamer-modified magnetic nanoparticles capturing loganin, and drying to obtain the loganin-modified magnetic nanoparticles. And separating the loganin from the aptamer modified magnetic nanoparticles to obtain the loganin. According to the invention, wall breaking is realized through photocatalytic reaction, and the aptamer modified magnetic nanoparticles capture loganin in a targeted manner, so that the extraction purity of loganin is improved synergistically.

The invention provides an adenovirus delivery system wrapped by a magnetic-guided palmitic acid modified cell membrane, and relates to the field of biomedicine, the technical key points are as follows: the system comprises a magnetized adenovirus and a macrophage cell membrane, the magnetized adenovirus is located inside, and the capsid protein of the magnetized adenovirus is connected with Fe3O4 magnetic nanoparticles with the diameter of 10nm through DP-PEG-MAL; the macrophage membrane wraps the adenovirus, and the surface protein of the macrophage membrane is covalently connected with palmitic acid through an MAL-PEG linker. The invention mainly aims to provide a magnetic-guided palmitic acid modified cell membrane-coated adenovirus delivery system (AdV-Fe3O4-coated PACM), so as to solve the problems that in the prior art, adenovirus lacks effective targeting after intravenous injection, the blood vessel penetrating efficiency is low, the enrichment capacity in target tissues is poor and the like.

The invention discloses photoaffinity magnetic nano-microspheres specifically enriched with bile acid acting targets as well as a construction method and application of the photoaffinity magnetic nano-microspheres. The microsphere is sequentially composed of Fe3O4 magnetic nanoparticles, a TAD photoaffinity link layer and a bile acid molecular layer from inside to outside, and is called BAs microsphere for short. Bile acid molecules are fixed on the surfaces of the BAs microspheres through a photoactivation coupling technology to serve as molecular bait, potential targets in a biological sample are captured by the bile acid molecules fixed on the surfaces of the microspheres on the basis of specific interaction characteristics, and different targets are enriched on the surfaces of solid-phase microspheres. The preparation method comprises the following steps: firstly, preparing a target spot, stripping the target spot from the surface of the microsphere through specific elution, and accurately identifying and analyzing by adopting a high-resolution mass spectrum, so as to obtain a direct acting target spot of a specific bile acid component, and further explaining the pharmacological mechanism of bile acid from the source of the target spot.

The application belongs to the technical field of medical biomaterials, and relates to a sultonium cationic polymer modified Fe3O4 magnetic nanoparticle, a sultonium cationic polymer (formula I) as shown in formula I is modified on the surface of the Fe3O4 magnetic nanoparticle through electrostatic interaction to obtain a sultonium cationic polymer modified Fe3O4 magnetic nanoparticle (formula II) as shown in formula II. The application also provides a preparation method and application of the sultonium cationic polymer modified Fe3O4 magnetic nanoparticle. The sultonium cationic polymer modified Fe3O4 magnetic nanoparticle provided by the application can be used for bacterial / fungal enrichment, sterilization and biofilm removal, and has good biocompatibility.

The invention belongs to the technical field of biological medicines, and particularly relates to a mercaptophenylboronic acid mediated nano-enzyme immunochromatography reagent and application thereof. According to the present invention, the detection sensitivity is improved by using the ability of the MPBA in broad-spectrum combination with the pathogen surface glycosylation molecule and combining the colorimetric catalysis dual enhancement effect of the virus-like bionic magnetic nano-enzyme (FeAu (at) AuIr); the probe takes Fe3O4 magnetic nano-particles as a core, large-particle-size gold nano-particles (Au) and high-catalytic-activity gold-iridium alloy (AuIr) are loaded in sequence, and the pathogen capturing capacity and the signal amplification effect are enhanced. And in combination with an antibody modified immunochromatography strip, streptococcus pneumoniae, pseudomonas aeruginosa and SARS-CoV-2 can be detected at the same time, so that the detection sensitivity is greatly improved. 170 clinical samples prove that the kit has a good application prospect in on-site rapid detection, and an efficient and low-cost scheme is provided for accurate screening of respiratory tract infection pathogens.

The invention discloses a preparation process of a magnetic bean dreg-based nitrogen-doped carbon-titanium dioxide ternary composite water purification filter element, and belongs to the technical field of environmental functional materials and water treatment. The process comprises the following steps: washing and drying agricultural waste bean dregs serving as a raw material, mixing with a nitrogen-containing precursor, and performing segmented high-temperature carbonization to prepare nitrogen-doped bean dreg carbon (N-BC) with high specific surface area; further performing in-situ growth of FeOmagnetic nanoparticles on the N-BC through a solvothermal method to obtain a magnetic carrier M-N-BC; and loading TiO nanoparticles on the surface of the M-N-BC by a sol-gel method, and calcining to obtain the M-N-BC / TiO ternary composite photocatalytic material. And finally, mixing the obtained material with a binder and a pore forming agent, and forming and sintering to prepare the multi-layer structure filter element. According to the prepared filter element, pollutants are enriched by utilizing high adsorbability of a carbon material, the pollutants are degraded by utilizing photocatalytic activity of TiO, and material recovery is realized by utilizing magnetism of FeO.

The invention relates to the technical field of preparation of adsorption materials, and provides a preparation method of metal-doped Fe3O4 magnetic nanoparticles and application of the metal-doped Fe3O4 magnetic nanoparticles in boron adsorption, a coprecipitation method is adopted as a main synthesis means, and optimization of a material structure and boron adsorption performance is realized by introducing specific metal elements into crystal lattices of ferroferric oxide (Fe3O4). The method is simple in process, mild in condition and easy for industrial production, effectively improves the adsorption capacity of ferroferric oxide to boron, and particularly has remarkable advantages in the aspect of treating boron-containing wastewater or enriching boric acid.

This invention discloses a graphene aerogel surface microwave absorbing material supported on Fe / N co-doped hollow carbon nanospheres and its preparation method. First, a reduced graphene oxide aerogel is prepared using graphene oxide as a raw material. Then, hollow Fe3O4 magnetic nanoparticles are prepared via a hydrothermal method using FeCl3·6H2O and ammonium acetate as raw materials. Finally, Fe3O4 / PPy / reduced graphene oxide aerogel is prepared by in-situ polymerization, and the graphene aerogel supported on Fe / N co-doped hollow carbon nanospheres is obtained through high-temperature heat treatment. The graphene aerogel surface microwave absorbing material supported on Fe / N co-doped hollow carbon nanospheres of this invention exhibits excellent dielectric and magnetic losses. Simultaneously, the magnetic Fe nanoparticles in the material can effectively convert electromagnetic wave energy, achieving excellent microwave absorption performance, and showing great potential in next-generation cutting-edge advanced nanocomposite materials.

The invention discloses a magnetic nanoprobe and a method for detecting fungaltoxin by a critical offset magnetic particle spectroscopy, the magnetic nanoprobe is formed by modifying the surface of a Fe3O4 magnetic nanoparticle with an antibody capable of specifically recognizing fungaltoxin, the antibody is coupled with an aldehyde group through an amino group modified on the surface of the Fe3O4 nanoparticle, and the magnetic nanoprobe is formed by detecting the fungaltoxin. Stable covalent linkage is formed, and targeted recognition and combination of the aflatoxin B1 and the deoxynivalenol are achieved. The magnetic nanoprobe adopted by the invention can realize detection and quantification of the target toxin through a critical offset magnetic particle spectrum technology under an unmarked condition, the nonlinear response of the Fe3O4 nanoparticles is excited through a bias magnetic field, and by measuring the magnetic phase change generated before and after the Fe3O4 nanoparticles are combined with the toxin, the detection and quantification of the target toxin can be realized. The sensitive detection on the target toxin is realized. The method has the advantages of high detection sensitivity, no elution operation, rapidness, low cost and the like.

The invention belongs to the technical field of biotechnology and medicine, and particularly relates to a magnetic field response type engineering bacterium intestinal targeting carrier system as well as a construction method and application thereof. The magnetic field response type engineering bacterium intestinal tract targeting carrier system is a temperature sensitive type engineering bacterium EcN-GadABC coated Fe3O4 magnetic nanoparticle coated polynoradrenaline; the temperature sensitive type engineering bacterium EcN-GadABC comprises a gene for coding the GadABC and a temperature response type promoter pRpL. The magnetic field response type engineering bacterium intestinal tract targeting carrier system provided by the invention can realize space-time manipulation, and provides possibility for the clinical application of recombinant engineering bacterium intestinal tract transplantation. Behavior data of a mouse in an experimental example shows that the magnetic field response type engineering bacterium intestinal tract targeting carrier system has a remarkable anti-anxiety effect, so that the magnetic field response type engineering bacterium intestinal tract targeting carrier system provided by the invention can be used for treating anxiety disorder.