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Magnetic fluorescent composite microsphere and method for preparing same

A composite microsphere and magnetic technology, applied in the field of composite materials, can solve problems such as the influence of fluorescent properties of fluorescent substances

Inactive Publication Date: 2012-01-04
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention focuses on solving the problem of Fe in the process of preparing magnetic fluorescent microspheres. 3 o 4 The problem that magnetic nanoparticles have a great influence on the fluorescence properties of fluorescent substances

Method used

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  • Magnetic fluorescent composite microsphere and method for preparing same
  • Magnetic fluorescent composite microsphere and method for preparing same
  • Magnetic fluorescent composite microsphere and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Take 1mgFe 3 o 4 Magnetic nanoparticles and 10 mg of styrene polymer microspheres with a cross-linking degree of 100% and a particle size of 50 μm were respectively dispersed in 1 ml of chloroform and 10 ml of n-butanol, and the two systems were mixed, dispersed uniformly by ultrasonic, and swelled at room temperature 10 min, centrifuged to prepare magnetic microspheres.

[0028] 2) Disperse 2mg of CdSeTe quantum dots and 10mg of prepared magnetic microspheres in 2ml of chloroform and 12ml of hexadecane respectively, mix the two systems, disperse them uniformly by ultrasonic, and swell at 40°C for 30min;

[0029] 3) The temperature of the reaction system in step 2) is raised to 140° C., and the temperature is kept until there is no reflux of chloroform;

[0030] 4) After the chloroform is completely volatilized, the reaction system is cooled down, centrifuged, washed and then dried to obtain magnetic fluorescent polymer microspheres.

[0031] image 3 Scanning el...

Embodiment 2

[0033] 1) Take 1mgFe 3 o 4 Magnetic nanoparticles and 50 mg of polymethyl methacrylate polymer microspheres with a cross-linking degree of 5% and a particle size of 5 μm were respectively dispersed in 6 ml of cyclohexane and 6 ml of isopropanol, and the two systems were mixed and ultrasonically dispersed uniformly. Swell at room temperature for 120 minutes, and centrifuge to prepare magnetic microspheres.

[0034] 2) Take 1mg of CdSe / ZnSe quantum dots with a fluorescence emission peak at 650nm and 50mg of magnetic microspheres and disperse them in 7ml of cyclohexane and 7ml of octadecene respectively, mix the two systems, disperse them evenly with ultrasound, and swell at 60°C. Swelling time 120min;

[0035] 3) The temperature of the reaction system in step 2) is raised to 240° C., and the temperature is kept until there is no reflux of cyclohexane;

[0036] 4) After the cyclohexane is completely volatilized, the temperature of the reaction system is lowered, centrifuged, w...

Embodiment 3

[0040] 1) Take 1mgFe 3 o 4 Magnetic nanoparticles and 20 mg of polyethyl methacrylate polymer microspheres with a cross-linking degree of 50% and a particle size of 20 μm were respectively dispersed in 1 ml of chloroform and 6 ml of isopropanol, and the two systems were mixed and dispersed uniformly by ultrasonic. Swell at room temperature for 90 minutes, and centrifuge to prepare magnetic microspheres.

[0041] 2) Take 1 mg of CdS quantum dots and 20 mg of magnetic microspheres and disperse them in 3 ml of cyclohexane and 9 ml of hexadecane respectively, mix the two systems, disperse them uniformly by ultrasonic, and swell at 55°C for 60 min;

[0042] 3) The temperature of the reaction system in step 2) is raised to 200° C., and the temperature is kept until there is no reflux of cyclohexane;

[0043] 4) After the cyclohexane is completely volatilized, the temperature of the reaction system is lowered, centrifuged, washed and then dried to obtain magnetic fluorescent polyme...

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Abstract

The invention aims at providing a simple and efficient method for preparing a high-performance magnetic fluorescent composite microsphere. Due to the existence of Fe3O4 magnetic nanoparticles, electrons of a fluorescent substance which are located at a conductance band are subjected to electron transfer in a process of returning to a valence band, the electrons of the conductance band are transferred on the Fe3O4 magnetic nanoparticles and fluorescence is subjected to quenching. The method provided by the invention is emphasized on solving the problem that the Fe3O4 magnetic nanoparticles cause large influence on the fluorescence performance of the fluorescent substance in a process of preparing a magnetic fluorescent microsphere. According to the preparing method provided by the invention, through changing a doping sequence and adopting different doping methods, the prepared magnetic fluorescent microsphere can minimize the influence on the fluorescent substance caused by magnetism on the basis of ensuring the magnetic fluorescent microsphere to have excellent magnetic property in actual use and enable the fluorescence performance to be optimal; and the fluorescent substance is introduced by adopting a high-temperature swelling method, so that fluorescent substances inside the microsphere cannot leak, and the stability of fluorescent signals is ensured. The mean particle diameter of the prepared magnetic fluorescent composite microsphere is 5-50 microns, and the particle diameter is even and has perfect appearance.

Description

technical field [0001] The invention relates to a composite material applicable to the field of biomedicine, in particular to a magnetic fluorescent composite microsphere and a preparation method thereof. Background technique [0002] In recent years, biomedical research has made remarkable achievements in functional gene analysis, drug screening and clinical diagnosis. At the same time, with the rapid development of combinatorial chemistry, natural product chemistry, and genomics, a large number of compounds to be screened and analyzed continue to emerge. How to efficiently and quickly screen out target substances from large-scale and complex candidate systems of biologically related substances to promote the development of biomedical research is a huge challenge for bioanalytical technologies at present. [0003] Magnetic fluorescent microspheres refer to the introduction of magnetic nanoparticles and fluorescent substances into polymer microspheres, so that the microsphe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02H01F1/11C09K11/88C09K11/56
Inventor 常津刘俊庆宋涛李云红张琼文
Owner TIANJIN UNIV
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