Preparation method of porous magnetic polystyrene microspheres

A technology of polystyrene microspheres and polyvinylpyrrolidone is applied in the direction of magnetism of organic materials/organic magnetic materials to achieve uniform distribution, uniform distribution of micropores and good shape.

Active Publication Date: 2013-03-13
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are few reports on the preparation of porous magnetic polymer microspheres. In order to obtain porous magnetic polymer microspheres with smaller particle sizes, so that they can fully demonstrate the advantages of small-sized microspheres and expand their application range, The invention provides a preparation method of porous magnetic polymer microspheres

Method used

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  • Preparation method of porous magnetic polystyrene microspheres
  • Preparation method of porous magnetic polystyrene microspheres
  • Preparation method of porous magnetic polystyrene microspheres

Examples

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Embodiment 1

[0030] Embodiment 1: the preparation of material.

[0031] Refining of styrene: wash repeatedly with 200ml 5wt% NaOH aqueous solution until colorless to remove polymerization inhibitor, wash with distilled water three times, then add anhydrous CaCl 2 Dry and store in brown bottles for later use.

[0032] Refining of benzoyl peroxide (BPO): Dissolve 10g of BPO in 50ml of chloroform and stir to dissolve, filter, drop the filtrate into 100ml of methanol, put it in the refrigerator to stand still, and obtain white needle crystals, wash with a small amount of cold methanol three times, vacuum at room temperature Dry for 10 hours, put into a brown jar, and keep refrigerated for later use.

[0033] Fe 3 o 4 Preparation of magnetic nanoparticles: 4.28g FeCl 2 4H 2 O, 11.70gFeCl 3 ·6H 2 O was dissolved in 180ml of water, stirred and dissolved, and the temperature was raised to 60°C after passing through nitrogen to drive oxygen for 0.5h, and 20.0ml of NH 3 ·H 2 O, the system c...

Embodiment 2

[0034] Example 2: Preparation of porous magnetic polystyrene microspheres.

[0035] Specifically include the following steps:

[0036] (1) get the dry Fe prepared by 0.8g embodiment 1 3 o 4 Magnetic nanoparticles were added to 100ml 50(v / v)% ethanol aqueous solution, and then the mixture was ultrasonically treated for 30min, and 1ml vinyltriethoxysilane was gradually added dropwise until the dissolved Fe 3 o 4in the suspension. Afterwards, transfer to the 250m1 three-neck flask, under N 2 Under protection, it was rapidly stirred at 40°C for 12 hours and aged at a constant temperature. The obtained product was washed three times with absolute ethanol and twice with deionized water, then dried under vacuum at 40° C., and ground into powder.

[0037] (2) Take 0.5g of the powder obtained in step (1) and 0.2g of purified BPO, add it to a test tube containing 6ml of styrene, 2ml of toluene, 1ml of n-heptane and 0.5ml of DVB cross-linking agent, place Ultrasonic mixing in ultr...

Embodiment 3

[0041] Specifically include the following steps:

[0042] (1) get the dry Fe prepared by 1g embodiment 1 3 o 4 Magnetic nanoparticles were added to 100ml 40(v / v)% ethanol aqueous solution, then the mixture was ultrasonically treated for 20min, and 2ml vinyltriethoxysilane was gradually added dropwise until the dissolved Fe 3 o 4 in the suspension. Afterwards, transfer to the 250m1 three-neck flask, under N 2 Under protection, it was rapidly stirred at 50°C for 24 hours and aged at a constant temperature. The obtained product was washed three times with absolute ethanol and three times with deionized water, then vacuum-dried at 60° C., and ground into powder.

[0043] (2) Take 0.34g of powder obtained in step (1) and 0.17g of purified BPO, add it to a test tube containing 8ml of styrene, 2ml of toluene, 1ml of n-heptane and 0.5ml of DVB cross-linking agent, place Ultrasonic mixing in ultrasound for 0.5h.

[0044] (3) Measure 100ml of deionized water into a 150ml beaker, ...

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Abstract

The invention discloses a preparation method of porous magnetic polystyrene microspheres. The method comprises steps of: (1) adding dry Fe3O4 magnetic nanoparticles into an aqueous ethanol solution, treating with ultrasonic, adding vinyltriethoxysilane, transferring into a reactor together, stirring under a constant temperature and a nitrogen atmosphere for aging, and then washing, drying under vacuum and grinding the obtained product into powder; (2) mixing the powder obtained in the step (1) and benzoyl peroxide, and then adding into styrene containing a pore forming agent and a cross-linking agent for the ultrasonic treating; (3) dissolving polyvinylpyrrolidone and sodium dodecyl sulfate into water by using the ultrasonic; and (4) adding the liquid obtained in the step (2) into the liquid obtained in the step (3), treating with the ultrasonic, pouring the obtained mixture into a reactor, heating for condensation reflux to obtain a suspension liquid, separating with magnet, washing with ethanol, re-separating with the magnet, re-washing with pure water, drying under vacuum and grinding to obtain claybank powdery product, extracting with a soxhlet way, and drying under vacuum to obtain the finish product.

Description

technical field [0001] The invention relates to a preparation method of porous magnetic polymer microspheres, in particular to a preparation method of porous magnetic polystyrene microspheres. Background technique [0002] With the development of life sciences, rapid and efficient separation and analysis of biomacromolecules has attracted more and more attention. As a separation method developed in recent years, biomagnetic separation technology has the advantages of high efficiency, rapidity, less solvent consumption, and easy automation, and is popular in the fields of biology, biotechnology, and biomedicine. Biomagnetic separation requires magnetic balls with regular spherical shape, uniform particle size, good dispersion, strong magnetic response, and superparamagnetism. In order to make biomagnetic separation technology more widely used, magnetic spheres with carboxyl, hydroxyl, epoxy, amine and other functional groups on the surface should be prepared. Magnetic sphere...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F212/08C08F212/36C08F2/20C08J9/28H01F1/42
Inventor 徐鹏张蕤苏天翔
Owner NANJING FORESTRY UNIV
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