Method for preparing monodisperse Fe3O4 magnetic nanoparticles

A magnetic nanoparticle, monodisperse technology, applied in the direction of inorganic material magnetism, ferrous oxide, iron oxide/ferric hydroxide, etc., can solve the problems of expensive and toxic reagents, achieve stable quality, simple synthesis process, high yield effect

Inactive Publication Date: 2009-09-23
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In above-mentioned these preparation methods, there is reagent expensive (as, Fe(acac) 3 , 1,2-hexadecanediol and oleylamine, etc.) and toxic (such as Fe(CO) 5 , 2-pyrrolidone, etc.) and the need for screening and nitrogen protection and other shortcomings or deficiencies

Method used

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  • Method for preparing monodisperse Fe3O4 magnetic nanoparticles
  • Method for preparing monodisperse Fe3O4 magnetic nanoparticles
  • Method for preparing monodisperse Fe3O4 magnetic nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] According to the molar ratio of precursor: stabilizing agent is 1: 4, and the molar ratio of precursor: high temperature organic solvent is 1: 10, accurately weigh the precursor iron oxide yellow (Fe 2 o 3 ·H 2 O) 10mmol, stabilizer oleic acid 40mmol and high-temperature organic solvent 1-octadecene 100mmol (35.5mL) were added to a 250mL three-necked flask reactor, an air condenser was installed, and then, magnetically stirred, reacted at 320°C for 10 hours, and the reaction After finishing, cool down to room temperature naturally. Then, add 180mL of precipitating agent of toluene and absolute ethanol mixed solution (volume ratio is 1: 2), ultrasonic treatment for 20 minutes, after separating with permanent magnet or centrifuge, obtain black precipitate, so far is called separation step; The separation step was repeated twice, and the obtained black precipitate was dried at 50°C. Its yield is about 1.5g, the product Fe 3 o 4 The average particle size of the magneti...

Embodiment 2

[0016] According to the molar ratio of precursor: stabilizing agent is 1: 7, and the molar ratio of precursor: high temperature organic solvent is 1: 10, accurately weigh the precursor iron oxide yellow (Fe 2 o 3 ·H 2 O) 10mmol, stabilizer oleic acid 70mmol and high-temperature organic solvent 1-octadecene 100mmol (35.5mL) were added in a 250mL three-necked flask reactor, an air condenser was installed, and then, magnetically stirred, reacted at 300°C for 6 hours, and the reaction After finishing, cool down to room temperature naturally. Then, add the precipitant of 180mL of toluene and isopropanol mixed solution (volume ratio is 1: 3), ultrasonic treatment 20 minutes, after separating with permanent magnet or centrifuge, obtain black precipitation, so far is called separation step; The separation step was repeated twice, and the obtained black precipitate was dried at 50°C. Its yield is about 1.3g, the product Fe 3 o 4 The average particle diameter of the magnetic nanopa...

Embodiment 3-14

[0017] Embodiment 3-14: implement according to the parameters in the table, the operation method is the same as embodiment 1 or 2.

[0018] Example 3-14 parameter table

[0019]

[0020] Acetone 1 / 3

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Abstract

The invention provides a method for preparing monodisperse Fe3O4 magnetic nanoparticles. Precursor is Fe2O3 or iron oxide yellow which has the chemical formula of Fe2O3.H2O; stabilizing agent is oleic acid; high temperature organic solvent is 1-octadecylene (b. p. 318DEG C); precipitating agent is prepared by mixing any two of toluene, dimethyl benzene, ethanol, isopropanol and acetone according to the volume ratio of 1:4-2:3; the mol ratio between the precursor and the stabilizing agent is 1:4-1:9; the mol ratio between the precursor and the high temperature organic solvent is 1:10; inert gas protection is not needed, and the Fe3O4 magnetic nanoparticles which have small sizes, monodisperse, narrow distribution, high saturation magnetization intensity and superparamagnetism. The method can be widely applied to biomedicine fields such as magnetic resonance imaging, biological magnetic separation, magnetic target drug carrier, biological magnetic marker and the like, and the high technical fields such as magnetic sealing, aerospace lubrication, magnetic anti-counterfeiting ink material, etc.

Description

technical field [0001] The present invention relates to a monodisperse Fe 3 o 4 Preparation method of magnetic nanoparticles. Background technique [0002] Magnetic iron oxide nanoparticles have been favored and valued for their special magnetic properties in biomedical applications (such as magnetic resonance imaging, magnetic hyperthermia, biomagnetic separation, magnetically targeted drug carriers, etc.). The particle size, size distribution, monodispersity and magnetic responsiveness of magnetic iron oxide nanoparticles are crucial to their biomedical applications, because small-sized magnetic nanoparticles have the ability to interact with viruses (20-450nm), proteins ( 5-50nm), DNA or gene (2nm wide and 10-100nm long), and thus suitable for combining with these biological units to form magnetic markers; Studies on the distribution and pharmacokinetics in organisms provide targeted drug carriers with almost the same physical, chemical and biological properties; high ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08H01F1/11
Inventor 张吉林洪广言倪嘉缵孙德慧
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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