Method for preparing monodisperse Fe3O4 magnetic nanoparticles

A magnetic nanoparticle, monodisperse technology, applied in the direction of inorganic material magnetism, ferrous oxide, iron oxide/ferric hydroxide, etc., can solve the problems of expensive and toxic reagents, achieve stable quality, simple synthesis process, high yield effect
CN101538068AInactive Publication Date: 2009-09-23CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2009-09-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for preparing monodisperse Fe3O4 magnetic nanoparticles. Precursor is Fe2O3 or iron oxide yellow which has the chemical formula of Fe2O3.H2O; stabilizing agent is oleic acid; high temperature organic solvent is 1-octadecylene (b. p. 318DEG C); precipitating agent is prepared by mixing any two of toluene, dimethyl benzene, ethanol, isopropanol and acetone according to the volume ratio of 1:4-2:3; the mol ratio between the precursor and the stabilizing agent is 1:4-1:9; the mol ratio between the precursor and the high temperature organic solvent is 1:10; inert gas protection is not needed, and the Fe3O4 magnetic nanoparticles which have small sizes, monodisperse, narrow distribution, high saturation magnetization intensity and superparamagnetism. The method can be widely applied to biomedicine fields such as magnetic resonance imaging, biological magnetic separation, magnetic target drug carrier, biological magnetic marker and the like, and the high technical fields such as magnetic sealing, aerospace lubrication, magnetic anti-counterfeiting ink material, etc.
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Description

technical field

[0001] The present invention relates to a monodisperse Fe 3 o 4 Preparation method of magnetic nanoparticles. Background technique

[0002] Magnetic iron oxide nanoparticles have been favored and valued for their special magnetic properties in biomedical applications (such as magnetic resonance imaging, magnetic hyperthermia, biomagnetic separation, magnetically targeted drug carriers, etc.). The particle size, size distribution, monodispersity and magnetic responsiveness of magnetic iron oxide nanoparticles are crucial to their biomedical applications, because small-sized magnetic nanoparticles have the ability to interact with viruses (20-450nm), proteins ( 5-50nm), DNA or gene (2nm wide and 10-100nm long), and thus suitable for combining with these biological units to form magnetic markers; Studies on the distribution and pharmacokinetics in organisms provide targeted drug carriers with almost the same physical, chemical and biological properties; high ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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