Degradable medical biological MgCa and preparation

An alloy and biological technology, applied in the field of medical metal biological implant materials, can solve problems such as degradation and disappearance, and achieve the effects of low production cost, reduced stress shielding effect, and simple production process

Inactive Publication Date: 2008-08-27
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as a biodegradable material, its surface will also degrade and disappea

Method used

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  • Degradable medical biological MgCa and preparation
  • Degradable medical biological MgCa and preparation
  • Degradable medical biological MgCa and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 315 grams of pure magnesium and 16.4 grams of MgCa30 master alloy, and melt them into Mg-0.7Ca alloy according to the above method. The obtained Mg-0.7Ca alloy is cut into 10×10×5mm 3 Cubic sample, heated to 480 °C in a tube furnace, with N 2 As a protective atmosphere, after 1.5 hours of heat preservation, it was taken out of the furnace and cooled to room temperature to obtain a biodegradable MgCa alloy.

[0032] As-cast metallographic structure of Mg-0.7Ca alloy see figure 1 , the structure of MgCa alloy after heat treatment can be seen figure 2 . The hardness of MgCa alloy after heat treatment is HV75, which is higher than that of pure magnesium HV25.

[0033] Grind the heat-treated sample with 800#, 1000#, 1400# sandpaper until the mirror surface is smooth. Then it was ultrasonically cleaned in acetone for 10 minutes, immersed in simulated body fluid (SBF), and its corrosion rate was measured by weight loss method, and compared with pure magnesium that h...

Embodiment 2

[0040] The difference from Example 1 is that during smelting, the pure magnesium is 302 grams, and the MgCa 30 master alloy is 32.8 grams, and the Mg-2.0Ca alloy is made, and the obtained Mg-2.0Ca alloy is heated to 500 ° C, and the holding time is 2 hours. Step is identical with embodiment 1.

[0041] Figure 5For: Mg-2.0Ca alloy cast state, Figure 6 It is the metallographic structure of MgCa alloy after heat treatment. The hardness of MgCa alloy after heat treatment is HV86.

[0042] Figure 7 It is the weight loss curve of Mg-2.0Ca alloy and pure magnesium, it can be seen that the weight loss rate of the alloy is higher than that of pure magnesium. It can be used as a replacement material for human hard tissue that requires rapid degradation, or as a temporary fixation material for hard tissue damage.

[0043] in conclusion:

[0044] The order of the degradation rate of MgCa alloys with different components in SBF from fast to slow is: Mg-2.0Ca>Mg-0.7Ca. After the M...

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Abstract

The invention relates to a medical biological MgCa alloy which can be degraded and a preparation method thereof. The components of the alloy includes 0.5 to 2.0 percent of calcium, and marginal magnesium; the alloy is made by fire melting, and the process of melting and pouring adopts argon shield; the melting temperature is 700 to 800 DEG C, and the pouring temperature is 650 to 750 DEG C. The thermal treatment process uses nitrogen as the protective atmosphere, with the heating temperature being 450 to 510 DEG C for 1.5 to 3.0 hours. The alloy can degrade by corrosion in physical environment, and induce the deposition of calcium phosphate ceramics; the changing of calcium content can control the degradation speed. The alloy can be used as the material for hard tissue replacement and intervening treatment, can be degraded fully after being implanted in human body for certain time and can transform into natural bone tissue. The medical biological MgCa alloy has the advantages of simple production process, no need of special equipment and low production cost.

Description

technical field [0001] The invention relates to a medical metal bio-implantation material, in particular to a degradable bio-implantation metal material with controllable degradation rate and calcium phosphate ceramic induction performance. technical background [0002] In the 20th century, many types of metal-based hard tissue implant materials have been successfully developed. These metal bio-implant materials are often used as implanted human bone materials, making the types of implanted human bone materials more extensive. However, there are still many problems in the use of these materials. For example, the nickel-titanium alloy implanted in the body may cause potential harm to the human body due to the release of nickel. The widely used titanium alloy also has the phenomenon of causing allergies, and because its elastic modulus is much higher than that of natural bone, it is suitable for hard tissue implantation. At the same time, it bears more load than the natural b...

Claims

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Application Information

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IPC IPC(8): A61L27/04C22C23/00C22C1/02C22F1/06
Inventor 高家诚王勇伍沙
Owner CHONGQING UNIV
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