The invention relates to a method for refining nitride inclusions in a nickel base deformation high temperature alloy. The method includes the following steps that (1), surface pretreatment of metal raw materials is carried out; (2), vacuum induction melting is carried out, specifically, Ni, Cr, Co, W, Mo and so on are put into a crucible and vacuumized, C, Nb, Ti and Al are added after melting, agon is filled, B and Zr are added, then the product is completely melted and poured into a steel mold, and a high temperature alloy electrode is obtained; and (3), vacuum electroslag remelting is carried out, specifically, slag charges containing 0.01-0.5 wt.% of MgO are used, vacuumed to 0.01-100 Pa and then filled the high purity agon to 0.01-0.06 MPa, and slugging and refining are carried out.According to the method for refining the nitride inclusions in the nickel base deformation high temperature alloy, fine even distributed MgO inclusions are formed through a metallurgical reaction of slag and alloy liquid during electroslag remelting, and the core for subsequent formation of the nitride inclusions is provided; the size of the nitride inclusions is decreased, and distribution is more uniform; vacuum electroslag remelting can reduce the number of the nitride inclusions; and by controlling the MgO content in electroslag and technological parameters of electroslag remelting, the content of Mg and the quantity and size of Mg oxide inclusions in the alloy can be precisely controlled, the process is stable, and costs are low.