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Surface nano-scale modified calcium phosphate bioactive ceramic as well as preparation method and application thereof

A calcium phosphate biological and active ceramic technology, applied in the field of biomedical materials, can solve problems such as sintering process constraints and bottlenecks, and achieve the effects of enhancing mechanical strength, improving bone-inducing ability, and inhibiting the growth of bone tumor cells

Active Publication Date: 2014-03-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although there have been many research reports on the synthesis, preparation and evaluation of calcium phosphate nanoparticles and microparticles, in their related applications, nano-calcium phosphate materials are mostly in the form of dispersion, such as nanoparticles, microparticles, or in the second phase Form doping and compounding in other matrix materials (such as polymer materials, collagen, etc.), and the preparation of bulk nanocrystalline calcium phosphate bioactive ceramic materials has always been a bottleneck in its development and application due to the limitation of sintering process

Method used

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  • Surface nano-scale modified calcium phosphate bioactive ceramic as well as preparation method and application thereof
  • Surface nano-scale modified calcium phosphate bioactive ceramic as well as preparation method and application thereof
  • Surface nano-scale modified calcium phosphate bioactive ceramic as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0068] 1) Synthesize β-phase tricalcium phosphate (β-TCP) powder through "wet chemical reaction" (refer to Biomaterials 2004;25:659-67 for specific steps), dry and air-flow pulverize, and screen with a diameter of 80-160 The dry powder of μm is used as the precursor powder for the preparation of the porous ceramic body;

[0069] 2) Use the "hydrogen peroxide foaming method" to prepare the microporous structure of the matrix calcium phosphate ceramics. Use 5 wt% polyvinyl alcohol and hydrogen peroxide to prepare the ceramic slurry to a slimy state. After stirring evenly, heat and decompose the hydrogen peroxide in a microwave oven to generate gas. Foam ceramic slurry, place the ceramic slurry rich in foam in a mold of 80 × 30 × 30 mm (length × width × height) and dry to prepare a porous ceramic body;

[0070] 3) Put the porous ceramic body into a muffle furnace for sintering, heat up from room temperature to 1100 °C at a rate of 5 °C / min for 2 h for sintering, and then cool wit...

Embodiment 2

[0075] Using biphasic calcium phosphate ceramics (BCP) as the substrate for surface nano-modification treatment, the product preparation process and steps are the same as in Example 1, except that the ceramic powder synthesized by "wet chemical reaction" in step 1) The body is a biphasic calcium phosphate powder. On this basis, the porous ceramic body is made and sintered into porcelain, and then the surface of this biphasic calcium phosphate ceramic is modified by nanometerization. The obtained calcium phosphate active bioceramic material The pore structure is: porosity 75%, macropore diameter 150-300 μm, interpenetrating micro-pore diameter ~10 μm, microscopic grains: 2-10 μm; the ceramic surface is micro-nano whisker-like, the micro-nano The whiskers are 10-20 μm long and about 150 nm in diameter. The whisker density obtained is denser than that in Example 1, but the shape is thinner. This shows that the nano-processing of the surface of calcium phosphate ceramics is contro...

Embodiment 3

[0078] Using pure β-phase tricalcium phosphate ceramics as the substrate to carry out surface nano-modification treatment, the product preparation steps and process are the same as in Example 1, the difference is that the configuration of the surface treatment modification solution in step 4) is selected as phosphoric acid modulation pH = 5.0, immerse the β-TCP ceramic material with a ratio of 1:30 g / ml in the dilute phosphoric acid solution, and raise the temperature to 150 °C at a rate of 5 °C / min in a polytetrafluoroethylene substrate hydrothermal reactor, After reacting for 2 h, the surface was naturally cooled to room temperature to obtain surface nanosized calcium phosphate bioactive ceramics. The pore structure of the obtained calcium phosphate active bioceramic material is: porosity 75%, macropore diameter 150-300 μm, interpenetrating micropore diameter ~10 μm, micro-grains: 2-10 μm; ceramic surface is Micro-nano whisker shape, the micro-nano whisker is 8-15 μm long an...

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Abstract

The invention discloses surface nano-scale modified calcium phosphate bioactive ceramic and a preparation method thereof. The surface nano-scale modified calcium phosphate bioactive ceramic comprises a porous calcium phosphate ceramic base body and a nano modifying layer. The preparation method of the surface nano-scale modified calcium phosphate bioactive ceramic comprises the following steps: carrying out surface nano-scale modification onto the porous calcium phosphate ceramic base body by a hydrothermal method in acid liquor; and self-assembling the material surface to form a layer of nano calcium phosphate by modification treatment. Therefore, the material surface / interface has a relatively large specific surface area and is beneficial to adsorbing osteogenesis-associated proteins and cells; after being planted into a body, the material can quickly release calcium and phosphor ions to promote osteogenesis, so that the material has better biological activity and osteoconduction; meanwhile, the ceramic has better mechanical performance.

Description

technical field [0001] The invention relates to a surface nano-modified calcium phosphate bioactive ceramic material and a preparation method and application thereof, belonging to the field of biomedical materials. technical background [0002] Bioactive materials with "active repair function" and "adjustable biological response characteristics" are becoming an important development direction for current and future hard tissue repair. The concept of bioactivity was first proposed by Hench. In 1969, when Hench was studying bioglass, he found that after bioglass was implanted into the bone, it formed a chemical bond with the bone at the interface, which meant the concept of material bioactivity was proposed. Internationally recognized. Hench defines bioactive materials as a class of biological materials that can induce special biological reactions at the material interface, which leads to the formation of chemical bonds between tissues and materials. Bioactive ceramics refer...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/54A61L27/56C04B35/447
Inventor 周长春叶兴江樊渝江肖占文肖玉梅谭言飞张兴栋
Owner SICHUAN UNIV
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