Porous calcium phosphate ceramics based on coating of calcium sulfate salt and preparation method of porous calcium phosphate ceramics

Abstract

The invention discloses porous calcium phosphate ceramics based on coating of calcium sulfate salt. Calcium phosphate is taken as a substrate, andthe surface of the calcium phosphate is coated with the calcium sulfate salt to form a porous structure with arbitrary shapes; the hole types of holes in at least one dimension of directions are regular in the three-dimensional space directions in the porous structure, and the distances between the centers and edges of the holes are 50 to 2000 micrometers, and all the holes are interpenetrating. In addition, the invention further provides a preparation method of the porous ceramics. According to the designed porous ceramics, the quickly-degraded calcium sulfate salt is on the surface, and the slowly-degraded calcium phosphate are inside, so after the ceramics are implanted into a body, a gradient degradation processcan be formed, so that the porous ceramics are endowed with very high osteogenic activity, and the ceramics can maintain enough mechanical strength in a given period. Therefore, the designed porous ceramics have very high osteogenic activity, and the risk of rapid disintegration after implantation of the ceramics in the early and middle periods is also reduced.

Description

technical field [0001] The invention relates to the technical field of bioceramics, in particular to a calcium phosphate porous ceramic coated with calcium sulfate salt and a preparation method thereof. Background technique [0002] Processing calcium phosphate ceramics into a porous structure to endow and improve the biological functions of calcium phosphate ceramics has always been a research topic for hard tissue defect repair materials. For this reason, porous calcium phosphate ceramics with different pore sizes and pore structures and corresponding preparation methods have been disclosed so far. Nevertheless, the bioactivity of porous calcium phosphate ceramics prepared based on the current method is not satisfactory. In particular, the osteoinductivity of current porous calcium phosphate ceramics is relatively weak. [0003] In order to improve the osteoinductivity of porous calcium phosphate, a more conventional clinical method is to combine bone growth factors with...

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Problems solved by technology

[0006] Although the preparation of calcium sulfate-calcium phosphate into a porous structure improves its biological performance, the pore parameters of these porous composite ceramics, including pore diameter, pore structure, and pore distribution, are not ideal, and the osteoinductive performance is not good, which is not conducive to new bone growth

Moreover, evenly mixing calcium sulfate and calcium phosphate, such a combination may also lead to the disintegration of the composite ceramics due to the rapid degradation of calcium sulfate after the prepared ceramics are implanted in the body

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