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Bioactive glass-modified gelatin composite hydrogel as well as preparation method thereof

A technology of bioactive glass and composite hydrogel, which is applied in the field of preparation of biomedical materials, can solve the problems of unfavorable transport of nutrients and metabolites, low moisture content of composite scaffolds, complex preparation process, etc., and achieve good osteoinductive ability, The preparation method is simple and convenient, and the effect of a wide range of sources

Active Publication Date: 2017-05-31
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composite bone repair materials prepared by the above method have the following problems: (1) The preparation process is complicated, and multiple steps such as molding, freeze-drying and chemical cross-linking are required; (2) The stability of the scaffold needs to be improved by chemical cross-linking after molding. However, the cross-linking agent (such as glutaraldehyde) is easy to remain in the scaffold, causing cytotoxicity; (3) The water content of the composite scaffold is low, which is not conducive to the transportation of nutrients and metabolites

Method used

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  • Bioactive glass-modified gelatin composite hydrogel as well as preparation method thereof
  • Bioactive glass-modified gelatin composite hydrogel as well as preparation method thereof
  • Bioactive glass-modified gelatin composite hydrogel as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Preparation steps of bioactive glass powder:

[0035] Bioactive glass powder was prepared by organic template combined with sol-gel method. The specific synthesis process was as follows: firstly, 40 g of dodecylamine was added to a mixed solution of 250 ml of deionized water and 800 ml of absolute ethanol, and placed in a water bath at 40 °C. Stir in the pot until completely dissolved; then add 202 ml of ethyl orthosilicate and stir for 30 min; add 24 ml of triethyl phosphate and stir for 30 min; add 137 g of calcium nitrate tetrahydrate; continue to stir the obtained milky white solution for 3 h Finally, centrifuge the glass sol to obtain a white precipitate, dry it in a 60°C drying oven for 24 hours, and then place it in a muffle furnace for sintering at 650°C for 3 hours to obtain a bioactive glass powder.

[0036] (2) Preparation steps of modified gelatin (degree of substitution: 40%):

[0037] Modified gelatin is obtained by reacting active amino groups of gel...

Embodiment 2

[0040] (1) Preparation steps of bioactive glass powder:

[0041]The bioactive glass powder was prepared by organic template combined with sol-gel method. The specific synthesis process was as follows: First, 4 g of dodecylamine was added to a mixed solution of 25 ml of deionized water and 80 ml of absolute ethanol, and placed in a water bath at 40 °C. Stir in the pot until completely dissolved; then add 20.2 ml tetraethyl orthosilicate and stir for 30 min; add 2.4 ml triethyl phosphate and stir for 30 min; add 13.7 g calcium nitrate tetrahydrate; continue to stir the obtained milky white solution for 3 h Finally, centrifuge the glass sol to obtain a white precipitate, dry it in a 60°C drying oven for 24 hours, and then place it in a muffle furnace for sintering at 650°C for 5 hours to obtain a bioactive glass powder.

[0042] (2) Preparation steps of modified gelatin (degree of substitution: 60%):

[0043] The modified gelatin was obtained by reacting the active amino group o...

Embodiment 3

[0046] (1) Preparation steps of bioactive glass powder:

[0047] Bioactive glass powder was prepared by organic template combined with sol-gel method. The specific synthesis process was as follows: firstly, 8 g of dodecylamine was added to a mixed solution of 50 ml of deionized water and 160 ml of absolute ethanol, and the mixture was placed in a water bath at 40 °C. Stir in the pot until completely dissolved; then add 40.4 ml tetraethyl orthosilicate and stir for 30 min; add 4.8 ml triethyl phosphate and stir for 30 min; add 27.4 g calcium nitrate tetrahydrate; continue to stir the obtained milky white solution for 3 h Finally, the glass sol was centrifuged to obtain a white precipitate, dried in a 60°C drying oven for 24 hours, and then sintered in a muffle furnace at 650°C for 3 hours to obtain a bioactive glass powder.

[0048] (2) Preparation steps of modified gelatin (80% substitution):

[0049] The modified gelatin is obtained by reacting the active amino group of the ...

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Abstract

The invention discloses bioactive glass-modified gelatin composite hydrogel as well as a preparation method thereof, and belongs to the field of biomedical materials. The bioactive glass-modified gelatin composite hydrogel is prepared by the following steps: the bioactive glass powder is added into a solution of modified gelatin containing a photoinitiator, ultrasonic treatment and stirring are carried out, uniformly dispersed materials are poured into a die, and after UV-irradiation is carried out for a period of time, the bioactive glass-modified gelatin composite hydrogel is obtained. The bioactive glass-modified gelatin composite hydrogel has good biological activity, osteoinductivity and high water content (which is 80% or above), and the product is used for the fields of non-bearing bone defect repair, slow release of medicament, bone tissue engineering, and the like.

Description

technical field [0001] The invention belongs to the field of preparation of biomedical materials, in particular to a bioactive glass-modified gelatin composite hydrogel and a preparation method thereof. Background technique [0002] Trauma, tumor resection, deformity correction, infection and other reasons make the bone lose its bone quality and easily cause bone defects. At present, the most important method for treating bone defects is bone transplantation, including autologous bone and allogeneic bone. Autologous bone transplantation does not need to consider histocompatibility and immune rejection, but the source of donor bone is limited; allogeneic bone comes from a wide range of sources, but there are risks of immune rejection and infection of blood-borne viruses. Therefore, there is a need to research and develop new artificial bone repair materials to meet clinical needs. [0003] The main components of bone tissue are collagen and hydroxyapatite. From the perspec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/52A61K47/42C08H1/00
CPCA61K9/0002A61K47/42A61L27/446A61L27/52A61L2300/252A61L2300/412A61L2300/602A61L2430/02C08H1/00
Inventor 陈晓峰郑佳富
Owner SOUTH CHINA UNIV OF TECH
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