Provided is an intervention type in-vivo real-time tumor imaging method and system. The imaging method comprises the steps that the polarization directions of terahertz and infrared source emergent light waves are adjusted, the light waves are conducted to the tissue to be detected through an array optical-fiber bundle, signals reflected by the tissue are converted into vertically polarized waves and then enter a detector for imaging in an incidence mode. The imaging system comprises a terahertz and infrared source, a terahertz detector, a reshaping unit, a polarization unit, a polarization conversion unit and an intervention unit. The system works in a terahertz and infrared frequency band, can perform tumor diagnosis in the human body in real time, has more advantages compared with X-ray, CT examination and other technologies, is high in spatial resolution, and has more advantages than a pathological biopsy technology in rapid, accurate and noninvasive characteristics. The intervention type in-vivo real-time tumor imaging method is safer, more accurate, quicker and more convenient and has the good application prospect in tumor diagnosis.