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Mineralized collagen/bioceramic composite and manufacturing method thereof

A technology of collagen and bioceramics, applied in drug combination, dental preparations, tissue regeneration, etc., can solve the problems of undisclosed application of mineralized collagen, and achieve the effect of reasonable mechanical strength, good mechanical strength and good integrity

Active Publication Date: 2012-08-15
MAXIGEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the previous studies disclosed the application of mineralized collagen as a binder for bioceramic systems

Method used

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  • Mineralized collagen/bioceramic composite and manufacturing method thereof
  • Mineralized collagen/bioceramic composite and manufacturing method thereof
  • Mineralized collagen/bioceramic composite and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of Mineralized Collagen Slurry: Add 1 gram of solid fibrous collagen (Type I collagen) to a container containing 250 ml of purified water. Add 5.3 grams of trisodium phosphate (Na 3 PO 4 12H 2 O). Stir (mix) the aqueous mixture in a blender until the collagen is a homogeneous colloidal slurry. The pH of this collagen is greater than 10.

[0042] Dissolve 3.54 grams of calcium nitrate (Ca(NO 3 ) 2 4H 2 O) in 50 ml of pure water to form an aqueous solution of calcium nitrate. When pouring this calcium nitrate (Ca(NO 3 ) 2) solution in the collagen slurry, keep the collagen slurry in a blender and stir vigorously. Stirring was continued for several minutes, followed by standing still for one hour. After the reaction, the final pH of the collagen slurry remains close to 10 or higher. The slurry was then filtered with a separating funnel and washed several times with pure water until it was free of soluble impurities. If Hydroxyapatite (HA) is calciu...

Embodiment 1-1

[0045] One-half of the above-mentioned purified mineralized collagen slurry was mixed with 5 g of Hydroxyapatite (HA) particles with a particle size ranging from 0.5 mm to 2 mm. The mixed mineralized collagen is then shaped into rectangles and air-dried at room temperature. The weight of the composite of mineralized collagen and HA ceramics after air-drying is 6.25 grams (1.25 g of mineralized collagen and 5 grams of HA particles, i.e. 20% mineralized collagen protein with 80% HA). The composite material remained strong and showed no signs of disintegration after aging in water for several weeks.

Embodiment 2

[0047] Preparation of Mineralized Collagen Slurry: Add 0.5 g of solid fibrous collagen (Type I collagen) to a container containing 100 ml of purified water. Add 5.0 g of trisodium phosphate (Na 3 PO 4 12H 2 O). Stir (mix) the aqueous mixture in a blender until the collagen is a homogeneous colloidal slurry. The pH of this collagen is greater than 10.

[0048] Dissolve 2.53 grams of calcium nitrate (Ca(NO 3 ) 2 4H 2 O) in 50 ml of pure water to form an aqueous solution of calcium nitrate. When pouring this calcium nitrate (Ca(NO 3 ) 2 ) solution in the collagen slurry, keep the collagen slurry in a blender and stir vigorously. Stirring was continued for several minutes, followed by standing still for one hour. After the reaction, the final pH of the collagen slurry remains close to 10 or higher. The slurry was then filtered with a separating funnel and washed several times with pure water until it was free of soluble impurities. If HA is calcium phosphate deposited...

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Abstract

The present invention discloses a mineralized collagen / bioceramic composite useful as a hard tissue replacement material or substitute material, comprising about 10% to 95% by weight of mineralized collagen and about 5% to 90% by weight of bioceramics, and a method of manufacturing the same. Wherein, the mineralized collagen is used as a binder for the bioceramics, such as calcium phosphate ceramics, calcium sulfate ceramics, calcium carbonate ceramics, and other biocompatible ceramics. The bioceramic used in the mineralized collagen / bioceramic composite can be either in powder form or in granular form.

Description

technical field [0001] The present invention relates to a kind of compound that can be used in orthopedic surgery and maxillofacial surgery and dental application and its manufacturing method, especially relate to a kind of mineralized collagen that can be used as replacement (replacement) material or substitute (substitute) material of hard tissue Composite of protein and bioceramic and method for its manufacture. Background technique [0002] The composition of hard tissues, such as natural bone, includes collagen and inorganic calcium phosphates, especially biological apatite. Bone contains about 60 to about 75 weight percent bioapatite, while teeth contain greater than 98 weight percent bioapatite. Bioapatite is a naturally occurring calcium apatite-type material that is formed in the body by precipitation of bodily fluids under human conditions. Bioapatite has a similar structure to pure hydroxyapatite (HA), but contains some substitute ions for calcium, phosphorus, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/12A61L27/54A61K6/838
CPCA61L2430/02A61L27/24A61L27/46A61L27/12A61L27/54A61P19/00C08L89/06
Inventor 刘松村陈松青徐婉卿
Owner MAXIGEN BIOTECH
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