Porous polyaryletherketone material with bioactivity, and preparation method and application thereof

A polyaryletherketone, bioactive technology, applied in the field of porous polyaryletherketone materials and their preparation, can solve problems such as limited mechanical bonding

Active Publication Date: 2016-01-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with the tight combination between the titanium metal implant and the bone, due to the chemical and biological inertness of the PAEK polymer, a large amount of fibrous tissue is produced between the implant and the bone, resulting in the PAEK implant and the bone. Tissues exhibit limited mechanical bonding

Method used

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  • Porous polyaryletherketone material with bioactivity, and preparation method and application thereof
  • Porous polyaryletherketone material with bioactivity, and preparation method and application thereof
  • Porous polyaryletherketone material with bioactivity, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The specific preparation steps of the porous PEKK material in this embodiment are as follows:

[0079] 1) Weigh 0.20g of PEKK powder (powder particle size is 50 mesh), mix it with an appropriate amount of ethanol, and put it into the mold, apply a pressure of 42Mpa to compact;

[0080] 2) Weigh out 0.08g of PEKK powder and 0.40g of HA spherical particles and mix them evenly, then add an appropriate amount of ethanol and then perform wet mixing;

[0081] 3) Then add the uniformly mixed material in step 2) to the mold to spread it on top of the compacted material in step 1), and heat to 380°C;

[0082] 4) While applying pressure (40MPa) to the mold, heat and keep the pressure for 1 hour, after natural cooling, demold and take out the sample to obtain the mixed material body;

[0083] 5) Put the green sample obtained in (4) into hydrochloric acid and stir for 3 hours to remove the HA spherical particles to obtain porous PEKK, put it in deionized water for ultrasonic cleaning for 15 ...

Embodiment 2

[0086] Comparative experiment before and after chemical modification

[0087] The specific preparation process of the chemically modified porous PEKK-P (sulfonated porous PEKK-SP) material in this example is as follows: The porous PEKK-P sample prepared in Example 1 is put into 60wt% sulfuric acid for modification. After treatment for 1 hour, put it into deionized water and ultrasonic treatment for 15 minutes, repeat washing 4 times and then dry for 5 hours to obtain sulfonated porous PEKK-SP, which is recorded as sample 2.

[0088] Using scanning electron microscopy (SEM) and infrared spectroscopy (IR) to analyze the sulfonated porous PEKK ( Image 6 b) Sample and porous PEKK ( Image 6 a) The surface morphology and physical and chemical properties of the sample are compared and characterized, such as Image 6 with Figure 8 As shown, after chemical modification, on the one hand, the surface of the material can have a three-dimensional interconnected microporous structure, and on t...

Embodiment 3

[0090] Comparative test before and after bone-like apatite deposition

[0091] The specific preparation steps of the biologically active porous PEKK-P material in this example are as follows: soak the sulfonated porous PEKK-SP in simulated body fluid (SBF) to deposit bone-like apatite, take it out after 7 days and clean it with deionized water. Dry for 3 hours to obtain a bioactive porous PEKK-BSP material, which is recorded as sample 3. As a comparison, the porous PEKK without sulfonation treatment prepared in Example 1 was subjected to the operation of depositing bone-like apatite under the same conditions, and the obtained product was recorded as sample 4.

[0092] In this embodiment, the simulated body fluid (SBF) can be a commercially available simulated body fluid, or it can be configured according to the following components: Na + (140-150mM), K + (4-6mM), Mg 2+ (1-3mM),Ca 2+ (2-4mM),Cl - (140-150mM), HCO 3 - (3-10mM), HPO 4 - (0.5-1.0mM), SO 4 2- (0.5-1.0mM), pH (7.0-7.5). ...

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Abstract

The invention discloses a porous polyaryletherketone (PAEK) material with bioactivity, and a preparation method and an application thereof, and belongs to the field of biomedical materials. The method comprises the following steps: carrying out wet uniform mixing on PAEK powder and a calcium phosphate ceramic (CPC) spherical particle pore forming agent to obtain a mixture, filling a die with the mixture, applying a pressure to make the hard pore forming agent be arranged in a close packing approximating manner and remove superfluous PAEK powder, heating the die to realize fusion molding of the PAEK powder under hot pressing in order to obtain a PAEK / CPC body, and immersing the PAEK / CPC body in diluted hydrochloric acid to remove the pore forming agent CPC in order to obtain the porous PAEK material; and processing through concentrated sulfuric acid, and immersing in a simulated body fluid to obtain the bioactive porous PAEK material with a surface bone like apatite layer. The method has the advantages of simple process and good repeatability, and the obtained bioactive material has completely three dimensional through macro-pores and abundant surface micro-pores, and easily adjustable macro-porous dimension and amount of porosity, and can be used to prepare bioactive materials with a gradient pore structure. The bioactive porous PAEK material can be used to restore bone defects, and is especially suitable for being used in interbody fusion cages for spinal column restoration.

Description

technical field [0001] The invention belongs to the field of biomedical materials and implanted medical devices, and in particular relates to a biologically active porous polyaryletherketone material and its preparation method and application. technical background [0002] Polyaryletherketone (PAEK) polymer is a high-temperature thermoplastic polymer, which is composed of aromatic benzene ring groups linking ketone groups and ether groups in different orders and proportions to form its main chain structure. Among them, representative PAEK polymers include PEEK and PEKK materials. In recent years, PAEK-based polymers have been increasingly used as polymers due to their unique chemical geometry endowed with good chemical resistance, radiolucency, thermal stability, and mechanical properties that are closer to bone than metal materials. Biomaterials are used in the fields of orthopedics, trauma and spinal implant materials. However, compared with the tight combination between...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/32A61L27/56A61L27/54A61L27/50
Inventor 张凯袁波林海朱向东张兴栋
Owner SICHUAN UNIV
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