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Method for manufacturing biological bone wires usable for FDM (frequency-division multiplexing) 3D (three-dimensional) printer models
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A manufacturing method and printer technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems that the model cannot have a deeper application, it is difficult to meet everyone's needs, and the size is the same
Active Publication Date: 2016-07-13
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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[0003] FDM (Fused Deposition Modeling) 3D printing technology is one of the current mainstream 3D technologies, but currently FDM is mainly used in the desktop field, and the printed consumables are mainly PLF, ABS resin, etc., and the printed model cannot have deeper applications. Therefore, FDM models The scope of application is also limited
[0004] Bone repair widely uses commercialized bone defects to replace artificial bone models, but due to factory standard manufacturing, the size is the same, it is difficult to meet everyone's needs
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Embodiment 1
[0021] Embodiment 1 The method for manufacturing biological bone wire that can be used for FDM3D printers includes:
[0022] By weight, 70% of PLA is taken as a binder, 15% of biological grade nano-hydroxyapatite and 15% of biological grade nano-β-tricalcium phosphate are used as artificial osteoinductive repair matrix;
[0023] Use chloroform to disperse hydroxyapatite and β-tricalcium phosphate, and sonicate for 1 hour to obtain dispersion A;
[0024] Using the method of mechanical stirring, dissolve PLA into the dispersion liquid A, the stirring time is 1h, and obtain the mixture B;
[0025] The above-mentioned mixture B is dried to remove excess solvent to obtain a block mixture B;
[0026] The mixture B of the block is extruded into a wire rod with a diameter of 1.75 mm by a twin-screw extruder, the extrusion rate is 400r / min, the extrusion temperature is 200 degrees Celsius, and the length of the extruded wire rod is 50 meters, the wire rod is available Bio-bone filame...
Embodiment 2
[0029] By weight, take 50% PLA as binder, 15% biological grade nano-hydroxyapatite and 35% biological grade nano-β-tricalcium phosphate as artificial osteoinductive repair matrix;
[0030] Use 1,4-dioxane to disperse hydroxyapatite and β-tricalcium phosphate, and sonicate for 1 hour to obtain dispersion A;
[0031] Using the method of mechanical stirring, dissolve PLA into the dispersion liquid A, the stirring time is 1h, and obtain the mixture B;
[0032] The above-mentioned mixture B is dried to remove excess 1,4-dioxane to obtain a block mixture B;
[0033] The mixture B of the block is extruded into a wire rod with a diameter of 1.75 mm by a twin-screw extruder, the extrusion rate is 400 r / min, the extrusion temperature is 240 degrees Celsius, and the length of the extruded wire rod is 50 meters, the wire rod is available Bio-bone filaments for FDM 3D printers.
[0034] Insert the obtained wire into the feeding port of the FDM3D printer, input the bone STL model, and use...
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Abstract
The invention discloses a method for manufacturing biological bone wires useable for FDM (frequency-division multiplexing) 3D (three-dimensional) printer models.The method includes weighing, by weight, 10-90% of PLA (polylactic acid) and 90-10% of hydroxyapatite and beta-tricalcium phosphate; ultrasonically dispersing artificial bone induction and repair substrates by the aid of solvents to obtain dispersion liquid A; dissolving a binder into the dispersion liquid A by the aid of mechanical stirring processes so as to obtain mixtures B; drying the mixtures B and removing redundant solvents to obtain mixtures B for blocks; extruding the mixtures B for the blocks by the aid of double-screw extruders to obtain wires with the diameters of 1.75 millimeters.The PLA is used as the binder, and the hydroxyapatite and the beta-tricalcium phosphate are used as the artificial bone induction and repair substrates.The wires with the diameters of 1.75 millimeters are the biological bone wires.The method has the advantages that the biological bone wires manufactured by the aid of the method are combined with desktop machines and can be used for directly printing absorbable bone repair models, accordingly, the biological printing ranges can be greatly expanded, and biological printing access threshold can be lowered.
Description
technical field [0001] The invention belongs to the field of bioprinting bone repair, and in particular relates to a method for manufacturing a bio-bone wire that can be used in an FDM3D printer. Background technique [0002] 3D printing, also known as digital manufacturing or additive manufacturing, is a method based on digital model files to form workpieces by layer-by-layer deposition without the need to realize manufacturing molds. Therefore, 3D printing has the characteristics of fast, simple and personalized customization. [0003] FDM (Fused Deposition Modeling) 3D printing technology is one of the current mainstream 3D technologies, but currently FDM is mainly used in the desktop field, and the printed consumables are mainly PLF, ABS resin, etc., and the printed model cannot have deeper applications. Therefore, FDM models The scope of application is also limited. [0004] Commercial bone defect replacement artificial bone models are widely used in bone repair, but ...
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